Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial

Detalhes bibliográficos
Autor(a) principal: Miguel, Manuela Maria Viana [UNESP]
Data de Publicação: 2021
Outros Autores: Mathias-Santamaria, Ingrid Fernandes [UNESP], Rossato, Amanda [UNESP], Ferraz, Laís Fernanda Ferreira [UNESP], Rangel, Thiago Perez, Casarin, Renato Corrêa Viana, Tatakis, Dimitris N., Santamaria, Mauro Pedrine [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/jre.12934
http://hdl.handle.net/11449/233550
Resumo: Background: This study was conducted to evaluate the clinical, immunologic, and patient-centered outcomes of enamel matrix protein derivative (EMD) on excisional wounds in palatal mucosa. Materials: Forty-four patients in need of ridge preservation were randomly allocated into two groups: control group (n = 22): open palatal wound after free gingival graft (FGG) harvest and EMD group (n = 22): open palatal wound after FGG harvest that received 0.3 ml of EMD. Clinical and patient-centered parameters were analyzed for 3 months post-treatment. Wound fluid levels of inflammatory markers were assessed 3 and 7 days postoperatively. Results: No significant inter-group difference was observed in remaining wound area and re-epithelialization. EMD and control groups achieved wound closure and re-epithelialization 30 days postoperatively (p <.001), without inter-group differences. Similarly, number of analgesics and Oral Health Impact Profile scores did not present significant inter-group differences (p >.05). EMD appeared to selectively modulate wound fluid levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases-2. Conclusion: Within the limits of the present study, it can be concluded that EMD application to excisional palatal wounds using the investigated protocol does not provide clinical healing benefits, despite an apparent modulation of selected inflammatory markers.
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spelling Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trialenamel matrix proteinsgingival recessionpalatepatient outcome assessmentwound healingBackground: This study was conducted to evaluate the clinical, immunologic, and patient-centered outcomes of enamel matrix protein derivative (EMD) on excisional wounds in palatal mucosa. Materials: Forty-four patients in need of ridge preservation were randomly allocated into two groups: control group (n = 22): open palatal wound after free gingival graft (FGG) harvest and EMD group (n = 22): open palatal wound after FGG harvest that received 0.3 ml of EMD. Clinical and patient-centered parameters were analyzed for 3 months post-treatment. Wound fluid levels of inflammatory markers were assessed 3 and 7 days postoperatively. Results: No significant inter-group difference was observed in remaining wound area and re-epithelialization. EMD and control groups achieved wound closure and re-epithelialization 30 days postoperatively (p <.001), without inter-group differences. Similarly, number of analgesics and Oral Health Impact Profile scores did not present significant inter-group differences (p >.05). EMD appeared to selectively modulate wound fluid levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases-2. Conclusion: Within the limits of the present study, it can be concluded that EMD application to excisional palatal wounds using the investigated protocol does not provide clinical healing benefits, despite an apparent modulation of selected inflammatory markers.São Paulo State University (UNESP) Division of Periodontics Institute of Science and TechnologyDivision of Operative Dentistry Department of General Dentistry University of Maryland School of DentistryDepartment of Prosthodontics and Periodontics Division of Periodontics Piracicaba Dental SchoolCollege of Dentistry Division of Periodontology The Ohio State University (OSU)College of Dentistry - Lexington University of KentuckySão Paulo State University (UNESP) Division of Periodontics Institute of Science and TechnologyUniversidade Estadual Paulista (UNESP)University of Maryland School of DentistryPiracicaba Dental SchoolThe Ohio State University (OSU)University of KentuckyMiguel, Manuela Maria Viana [UNESP]Mathias-Santamaria, Ingrid Fernandes [UNESP]Rossato, Amanda [UNESP]Ferraz, Laís Fernanda Ferreira [UNESP]Rangel, Thiago PerezCasarin, Renato Corrêa VianaTatakis, Dimitris N.Santamaria, Mauro Pedrine [UNESP]2022-05-01T09:30:32Z2022-05-01T09:30:32Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1111/jre.12934Journal of Periodontal Research.1600-07650022-3484http://hdl.handle.net/11449/23355010.1111/jre.129342-s2.0-85115114586Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Periodontal Researchinfo:eu-repo/semantics/openAccess2022-05-01T09:30:32Zoai:repositorio.unesp.br:11449/233550Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-01T09:30:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
title Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
spellingShingle Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
Miguel, Manuela Maria Viana [UNESP]
enamel matrix proteins
gingival recession
palate
patient outcome assessment
wound healing
title_short Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
title_full Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
title_fullStr Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
title_full_unstemmed Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
title_sort Enamel matrix derivative effects on palatal mucosa wound healing: Randomized clinical trial
author Miguel, Manuela Maria Viana [UNESP]
author_facet Miguel, Manuela Maria Viana [UNESP]
Mathias-Santamaria, Ingrid Fernandes [UNESP]
Rossato, Amanda [UNESP]
Ferraz, Laís Fernanda Ferreira [UNESP]
Rangel, Thiago Perez
Casarin, Renato Corrêa Viana
Tatakis, Dimitris N.
Santamaria, Mauro Pedrine [UNESP]
author_role author
author2 Mathias-Santamaria, Ingrid Fernandes [UNESP]
Rossato, Amanda [UNESP]
Ferraz, Laís Fernanda Ferreira [UNESP]
Rangel, Thiago Perez
Casarin, Renato Corrêa Viana
Tatakis, Dimitris N.
Santamaria, Mauro Pedrine [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
University of Maryland School of Dentistry
Piracicaba Dental School
The Ohio State University (OSU)
University of Kentucky
dc.contributor.author.fl_str_mv Miguel, Manuela Maria Viana [UNESP]
Mathias-Santamaria, Ingrid Fernandes [UNESP]
Rossato, Amanda [UNESP]
Ferraz, Laís Fernanda Ferreira [UNESP]
Rangel, Thiago Perez
Casarin, Renato Corrêa Viana
Tatakis, Dimitris N.
Santamaria, Mauro Pedrine [UNESP]
dc.subject.por.fl_str_mv enamel matrix proteins
gingival recession
palate
patient outcome assessment
wound healing
topic enamel matrix proteins
gingival recession
palate
patient outcome assessment
wound healing
description Background: This study was conducted to evaluate the clinical, immunologic, and patient-centered outcomes of enamel matrix protein derivative (EMD) on excisional wounds in palatal mucosa. Materials: Forty-four patients in need of ridge preservation were randomly allocated into two groups: control group (n = 22): open palatal wound after free gingival graft (FGG) harvest and EMD group (n = 22): open palatal wound after FGG harvest that received 0.3 ml of EMD. Clinical and patient-centered parameters were analyzed for 3 months post-treatment. Wound fluid levels of inflammatory markers were assessed 3 and 7 days postoperatively. Results: No significant inter-group difference was observed in remaining wound area and re-epithelialization. EMD and control groups achieved wound closure and re-epithelialization 30 days postoperatively (p <.001), without inter-group differences. Similarly, number of analgesics and Oral Health Impact Profile scores did not present significant inter-group differences (p >.05). EMD appeared to selectively modulate wound fluid levels of monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, matrix metallopeptidase 9, and tissue inhibitor of metalloproteinases-2. Conclusion: Within the limits of the present study, it can be concluded that EMD application to excisional palatal wounds using the investigated protocol does not provide clinical healing benefits, despite an apparent modulation of selected inflammatory markers.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
2022-05-01T09:30:32Z
2022-05-01T09:30:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/jre.12934
Journal of Periodontal Research.
1600-0765
0022-3484
http://hdl.handle.net/11449/233550
10.1111/jre.12934
2-s2.0-85115114586
url http://dx.doi.org/10.1111/jre.12934
http://hdl.handle.net/11449/233550
identifier_str_mv Journal of Periodontal Research.
1600-0765
0022-3484
10.1111/jre.12934
2-s2.0-85115114586
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Periodontal Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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