Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate

Detalhes bibliográficos
Autor(a) principal: Teixeira, Giovana Rampazzo [UNESP]
Data de Publicação: 2020
Outros Autores: Mendes, Leonardo Oliveira, Veras, Allice Santos Cruz [UNESP], Thorpe, Hayley Hope Allyssa, Fávaro, Wagner José, De Almeida Chuffa, Luiz Gustavo [UNESP], Pinheiro, Patrícia Fernanda Felipe [UNESP], Martinez, Francisco Eduardo [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/s12944-020-1195-0
http://hdl.handle.net/11449/200015
Resumo: Background: Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Methods: Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Results: Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Conclusions: In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.
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spelling Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostateApoptosisCD36Physical exerciseSCAPSREBP-1Background: Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Methods: Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Results: Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Conclusions: In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.Department of Physiotherapy School of Technology and Sciences UNESP Campus of Presidente PrudentePostgraduate Program in Movement Sciences Sao Paulo State University-UNESPMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP)Postgraduate Program in Animal Science Postgraduate Program in Health Sciences University of Western São Paulo-UNOESTEDepartment of Biomedical Sciences Ontario Veterinary College University of GuelphDepartment of Structural and Functional Biology State University of Campinas - UNICAMP Institute of BiologyDepartment of Anatomy São Paulo State University UNESP Institute of BiosciencesDepartment of Physiotherapy School of Technology and Sciences UNESP Campus of Presidente PrudentePostgraduate Program in Movement Sciences Sao Paulo State University-UNESPMulticenter Graduate Program in Physiological Sciences SBFis São Paulo State University (UNESP)Department of Anatomy São Paulo State University UNESP Institute of BiosciencesUniversidade Estadual Paulista (Unesp)University of Western São Paulo-UNOESTEUniversity of GuelphUniversidade Estadual de Campinas (UNICAMP)Teixeira, Giovana Rampazzo [UNESP]Mendes, Leonardo OliveiraVeras, Allice Santos Cruz [UNESP]Thorpe, Hayley Hope AllyssaFávaro, Wagner JoséDe Almeida Chuffa, Luiz Gustavo [UNESP]Pinheiro, Patrícia Fernanda Felipe [UNESP]Martinez, Francisco Eduardo [UNESP]2020-12-12T01:55:21Z2020-12-12T01:55:21Z2020-01-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s12944-020-1195-0Lipids in Health and Disease, v. 19, n. 1, 2020.1476-511Xhttp://hdl.handle.net/11449/20001510.1186/s12944-020-1195-02-s2.0-8507868909657605609707515980000-0003-1452-5708Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLipids in Health and Diseaseinfo:eu-repo/semantics/openAccess2024-06-18T18:44:28Zoai:repositorio.unesp.br:11449/200015Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:35:04.872346Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
title Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
spellingShingle Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
Teixeira, Giovana Rampazzo [UNESP]
Apoptosis
CD36
Physical exercise
SCAP
SREBP-1
title_short Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
title_full Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
title_fullStr Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
title_full_unstemmed Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
title_sort Physical resistance training-induced changes in lipids metabolism pathways and apoptosis in prostate
author Teixeira, Giovana Rampazzo [UNESP]
author_facet Teixeira, Giovana Rampazzo [UNESP]
Mendes, Leonardo Oliveira
Veras, Allice Santos Cruz [UNESP]
Thorpe, Hayley Hope Allyssa
Fávaro, Wagner José
De Almeida Chuffa, Luiz Gustavo [UNESP]
Pinheiro, Patrícia Fernanda Felipe [UNESP]
Martinez, Francisco Eduardo [UNESP]
author_role author
author2 Mendes, Leonardo Oliveira
Veras, Allice Santos Cruz [UNESP]
Thorpe, Hayley Hope Allyssa
Fávaro, Wagner José
De Almeida Chuffa, Luiz Gustavo [UNESP]
Pinheiro, Patrícia Fernanda Felipe [UNESP]
Martinez, Francisco Eduardo [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
University of Western São Paulo-UNOESTE
University of Guelph
Universidade Estadual de Campinas (UNICAMP)
dc.contributor.author.fl_str_mv Teixeira, Giovana Rampazzo [UNESP]
Mendes, Leonardo Oliveira
Veras, Allice Santos Cruz [UNESP]
Thorpe, Hayley Hope Allyssa
Fávaro, Wagner José
De Almeida Chuffa, Luiz Gustavo [UNESP]
Pinheiro, Patrícia Fernanda Felipe [UNESP]
Martinez, Francisco Eduardo [UNESP]
dc.subject.por.fl_str_mv Apoptosis
CD36
Physical exercise
SCAP
SREBP-1
topic Apoptosis
CD36
Physical exercise
SCAP
SREBP-1
description Background: Altered lipid metabolism is an important characteristic of neoplastic cells, with androgens and growth factors being major regulatory agents of the lipid metabolism process. We investigated the effect of physical resistance training on lipid metabolism and apoptosis in the adult Wistar rat prostate. Methods: Two experimental groups represented sedentary and physical resistance training. Three days per week for 13 weeks, rats performed jumps in water carrying a weight load strapped to their chests as part of a physical resistance exercise protocol. Two days after the last training session, rats were anesthetized and sacrificed for blood and prostate analysis. Results: Physical exercise improved feeding efficiency, decreased weight gain, regulated the serum-lipid profile, and modulated insulin-like growth factor-1 (IGF-1) and free testosterone concentration. Furthermore, upregulation of cluster of differentiation 36 (CD36), sterol regulatory element binding protein-1 (SREBP-1), sterol regulatory element-binding protein cleavage-activating protein (SCAP), and reduced lysosome membrane protein (LIMPII) expression were also observed in the blood and prostates of trained rats. Consistent with these results, caspase-3 expression was upregulating and the BCL-2/Bax index ratio was decreased in trained rats relative to sedentary animals. Conclusions: In this work, physical resistance training can alter lipid metabolism and increase markers of apoptosis in the prostate, suggesting physical resistance training as a potential novel therapeutic strategy for treating prostate cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T01:55:21Z
2020-12-12T01:55:21Z
2020-01-29
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/s12944-020-1195-0
Lipids in Health and Disease, v. 19, n. 1, 2020.
1476-511X
http://hdl.handle.net/11449/200015
10.1186/s12944-020-1195-0
2-s2.0-85078689096
5760560970751598
0000-0003-1452-5708
url http://dx.doi.org/10.1186/s12944-020-1195-0
http://hdl.handle.net/11449/200015
identifier_str_mv Lipids in Health and Disease, v. 19, n. 1, 2020.
1476-511X
10.1186/s12944-020-1195-0
2-s2.0-85078689096
5760560970751598
0000-0003-1452-5708
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lipids in Health and Disease
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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