Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system

Detalhes bibliográficos
Autor(a) principal: Oliveira, Olga M. M. F.
Data de Publicação: 2015
Outros Autores: Brunetti, Iguatemy L., Khalil, Najeh M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100183&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/127380
Resumo: In this study, the effect of nicotine on the LDL oxidation by the MPO/H2O2/Cl- system and the effect of HOCl on LDL and some of its components, such as methyl linoleate, vitamin E and the amino acid tryptophan were explored. Nicotine, in micromolar concentrations, enhanced the tryptophan oxidation, either present in LDL or free, in solution. Nicotine also decreased the formation of conjugated dienes and oxygen consumption in a methyl linoleate / HOCl system, and there was evidence to suggest an increase in chlorohydrin formation. Acceleration of the vitamin E oxidation by HOCl was also observed in the presence of nicotine. These data show that the interaction of nicotine and HOCl can promote significant biochemical modifications in LDL particle and some of its components involved in the pathogenesis of cardiovascular and other diseases.
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spelling Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- systemNicotineMyeloperoxidaseHypochlorous acidLow-density lipoproteinMethyl linoleateVitamin ETryptophanNicotinaMieloperoxidaseÁcido hipoclorosoLipoproteína de baixa densidadeMetil linoleatoVitamina ETriptofanoIn this study, the effect of nicotine on the LDL oxidation by the MPO/H2O2/Cl- system and the effect of HOCl on LDL and some of its components, such as methyl linoleate, vitamin E and the amino acid tryptophan were explored. Nicotine, in micromolar concentrations, enhanced the tryptophan oxidation, either present in LDL or free, in solution. Nicotine also decreased the formation of conjugated dienes and oxygen consumption in a methyl linoleate / HOCl system, and there was evidence to suggest an increase in chlorohydrin formation. Acceleration of the vitamin E oxidation by HOCl was also observed in the presence of nicotine. These data show that the interaction of nicotine and HOCl can promote significant biochemical modifications in LDL particle and some of its components involved in the pathogenesis of cardiovascular and other diseases.Nesse estudo, nós avaliamos o efeito da nicotina sobre a oxidação da LDL pelo sistema MPO/H2O2/Cl- e o efeito do HOCl sobre a LDL e alguns de seus componentes, tais como metil linoleato, vitamina E e o aminoácido triptofano. Nicotina, em concentração micromolar, amplia a oxidação do triptofano, livre em solução ou presente na LDL. A nicotina promove a diminuição da formação de dienos conjugados e consumo de oxigênio no sistema metil linoleato/HOCl, e houve evidência que sugere aumento na formação de clorohidrinas. O aumento da oxidação da vitamina E pelo HOCl também foi observada na presença de nicotina. Esses dados mostram que a interação da nicotina e HOCl pode promover alterações bioquímicas significativas na partícula de LDL e alguns de seus componentes envolvidos na patogênese de doenças cardiovasculares e de outras doenças.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista, Instituto de Química Departamento de Bioquímica e Tecnologia QuímicaUniversidade Estadual Paulista, Faculdade de Ciências Farmacêuticas de AraraquaraUNICENTRO Departamento de FarmáciaUniversidade Estadual Paulista, Instituto de Química Departamento de Bioquímica e Tecnologia QuímicaUniversidade Estadual Paulista, Faculdade de Ciências Farmacêuticas de AraraquaraFAPESP: 1999/10229-6Academia Brasileira de CiênciasUniversidade Estadual Paulista (Unesp)UNICENTROOliveira, Olga M. M. F.Brunetti, Iguatemy L.Khalil, Najeh M.2015-08-26T19:21:38Z2015-08-26T19:21:38Z2015-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article183-192application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100183&lng=en&nrm=iso&tlng=enAnais da Academia Brasileira de Ciências, v. 87, n. 1, p. 183-192, 2015.0001-3765http://hdl.handle.net/11449/12738010.1590/0001-3765201520140156S0001-37652015000100183S0001-37652015000100183.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Ciências0.9560,418info:eu-repo/semantics/openAccess2023-12-07T06:13:48Zoai:repositorio.unesp.br:11449/127380Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:39:40.395874Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
title Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
spellingShingle Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
Oliveira, Olga M. M. F.
Nicotine
Myeloperoxidase
Hypochlorous acid
Low-density lipoprotein
Methyl linoleate
Vitamin E
Tryptophan
Nicotina
Mieloperoxidase
Ácido hipocloroso
Lipoproteína de baixa densidade
Metil linoleato
Vitamina E
Triptofano
title_short Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
title_full Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
title_fullStr Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
title_full_unstemmed Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
title_sort Nicotine-enhanced oxidation of low-density lipoprotein and its components by myeloperoxidase/H2O2/Cl- system
author Oliveira, Olga M. M. F.
author_facet Oliveira, Olga M. M. F.
Brunetti, Iguatemy L.
Khalil, Najeh M.
author_role author
author2 Brunetti, Iguatemy L.
Khalil, Najeh M.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
UNICENTRO
dc.contributor.author.fl_str_mv Oliveira, Olga M. M. F.
Brunetti, Iguatemy L.
Khalil, Najeh M.
dc.subject.por.fl_str_mv Nicotine
Myeloperoxidase
Hypochlorous acid
Low-density lipoprotein
Methyl linoleate
Vitamin E
Tryptophan
Nicotina
Mieloperoxidase
Ácido hipocloroso
Lipoproteína de baixa densidade
Metil linoleato
Vitamina E
Triptofano
topic Nicotine
Myeloperoxidase
Hypochlorous acid
Low-density lipoprotein
Methyl linoleate
Vitamin E
Tryptophan
Nicotina
Mieloperoxidase
Ácido hipocloroso
Lipoproteína de baixa densidade
Metil linoleato
Vitamina E
Triptofano
description In this study, the effect of nicotine on the LDL oxidation by the MPO/H2O2/Cl- system and the effect of HOCl on LDL and some of its components, such as methyl linoleate, vitamin E and the amino acid tryptophan were explored. Nicotine, in micromolar concentrations, enhanced the tryptophan oxidation, either present in LDL or free, in solution. Nicotine also decreased the formation of conjugated dienes and oxygen consumption in a methyl linoleate / HOCl system, and there was evidence to suggest an increase in chlorohydrin formation. Acceleration of the vitamin E oxidation by HOCl was also observed in the presence of nicotine. These data show that the interaction of nicotine and HOCl can promote significant biochemical modifications in LDL particle and some of its components involved in the pathogenesis of cardiovascular and other diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-26T19:21:38Z
2015-08-26T19:21:38Z
2015-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100183&lng=en&nrm=iso&tlng=en
Anais da Academia Brasileira de Ciências, v. 87, n. 1, p. 183-192, 2015.
0001-3765
http://hdl.handle.net/11449/127380
10.1590/0001-3765201520140156
S0001-37652015000100183
S0001-37652015000100183.pdf
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100183&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/127380
identifier_str_mv Anais da Academia Brasileira de Ciências, v. 87, n. 1, p. 183-192, 2015.
0001-3765
10.1590/0001-3765201520140156
S0001-37652015000100183
S0001-37652015000100183.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais da Academia Brasileira de Ciências
0.956
0,418
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 183-192
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129103029600256

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