Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study

Detalhes bibliográficos
Autor(a) principal: Martinelli, Patrícia Merly
Data de Publicação: 2020
Outros Autores: Sorpreso, Isabel Cristina Esposito, Raimundo, Rodrigo Daminello, de Souza Leal, Osvaldo, Zangirolami-Raimundo, Juliana, de Lima, Marcos Venicius Malveira, Pérez-Riera, Andrés, Pereira, Valdelias Xavier, Elmusharaf, Khalifa, Valenti, Vitor E. [UNESP], de Abreu, Luiz Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1371/journal.pone.0225866
http://hdl.handle.net/11449/201098
Resumo: Heart Rate Variability (HRV) represents cardiac autonomic behavior and have been related to menopausal symptoms, mainly vasomotor symptoms and their imbalance to cardiovascular risk. It is not clear in the literature which index represents this imbalance and what is their involvement with the menopausal state. The aim of this study was to evaluate HRV in menopausal transition and post-menopausal symptoms with different intensities. This cross-sectional study was conducted in Rio Branco, State of Acre, Brazil from October 2016 to July 2017. We used Kupperman-Blatt Menopausal Index (KMI) to measure menopausal symptoms intensity. HRV analysis was performed based on the guidelines of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. HRV is lower in the group with moderate/intense menopausal symptoms compared to mild symptoms. (RMSSD: p = 0.005, Cohen’s d = 0.53, pNN50: p = 0.0004, Cohen’s d = 0.68; HF: p = 0.024, Cohen’s d = 0.44). There was association between HRV and KMI (RMSSD: r = -1.248, p = 0.004; and pNN50: r = -0.615, p: 0.029) in inverse relation to the intensity of vasomotor symptoms in women in TM. In conclusion, HRV was able to distinguish menopausal symptoms, indicating reduced vagal control in women with more intense symptoms.
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spelling Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal studyHeart Rate Variability (HRV) represents cardiac autonomic behavior and have been related to menopausal symptoms, mainly vasomotor symptoms and their imbalance to cardiovascular risk. It is not clear in the literature which index represents this imbalance and what is their involvement with the menopausal state. The aim of this study was to evaluate HRV in menopausal transition and post-menopausal symptoms with different intensities. This cross-sectional study was conducted in Rio Branco, State of Acre, Brazil from October 2016 to July 2017. We used Kupperman-Blatt Menopausal Index (KMI) to measure menopausal symptoms intensity. HRV analysis was performed based on the guidelines of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. HRV is lower in the group with moderate/intense menopausal symptoms compared to mild symptoms. (RMSSD: p = 0.005, Cohen’s d = 0.53, pNN50: p = 0.0004, Cohen’s d = 0.68; HF: p = 0.024, Cohen’s d = 0.44). There was association between HRV and KMI (RMSSD: r = -1.248, p = 0.004; and pNN50: r = -0.615, p: 0.029) in inverse relation to the intensity of vasomotor symptoms in women in TM. In conclusion, HRV was able to distinguish menopausal symptoms, indicating reduced vagal control in women with more intense symptoms.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Laboratório de Delineamento de Estudos e Escrita Científica Centro Universitário Saúde ABCLaboratório de Delineamento de Estudos e Escrita Científica do Laboratório de Práticas Cientíticas Centro Universitário UninorteDisciplina de Ginecologia Faculdade de Medicina Universidade de São Paulo (USP)Graduate Entry Medical School University of LimerickCentro de Estudos do Sistema Nervoso Autônomo (CESNA) UNESPCentro de Estudos do Sistema Nervoso Autônomo (CESNA) UNESPCentro Universitário Saúde ABCCentro Universitário UninorteUniversidade de São Paulo (USP)University of LimerickUniversidade Estadual Paulista (Unesp)Martinelli, Patrícia MerlySorpreso, Isabel Cristina EspositoRaimundo, Rodrigo Daminellode Souza Leal, OsvaldoZangirolami-Raimundo, Julianade Lima, Marcos Venicius MalveiraPérez-Riera, AndrésPereira, Valdelias XavierElmusharaf, KhalifaValenti, Vitor E. [UNESP]de Abreu, Luiz Carlos2020-12-12T02:24:00Z2020-12-12T02:24:00Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1371/journal.pone.0225866PLoS ONE, v. 15, n. 1, 2020.1932-6203http://hdl.handle.net/11449/20109810.1371/journal.pone.02258662-s2.0-85077940738Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPLoS ONEinfo:eu-repo/semantics/openAccess2021-10-23T16:01:02Zoai:repositorio.unesp.br:11449/201098Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T16:01:02Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study
title Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study
spellingShingle Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study
Martinelli, Patrícia Merly
title_short Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study
title_full Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study
title_fullStr Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study
title_full_unstemmed Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study
title_sort Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study
author Martinelli, Patrícia Merly
author_facet Martinelli, Patrícia Merly
Sorpreso, Isabel Cristina Esposito
Raimundo, Rodrigo Daminello
de Souza Leal, Osvaldo
Zangirolami-Raimundo, Juliana
de Lima, Marcos Venicius Malveira
Pérez-Riera, Andrés
Pereira, Valdelias Xavier
Elmusharaf, Khalifa
Valenti, Vitor E. [UNESP]
de Abreu, Luiz Carlos
author_role author
author2 Sorpreso, Isabel Cristina Esposito
Raimundo, Rodrigo Daminello
de Souza Leal, Osvaldo
Zangirolami-Raimundo, Juliana
de Lima, Marcos Venicius Malveira
Pérez-Riera, Andrés
Pereira, Valdelias Xavier
Elmusharaf, Khalifa
Valenti, Vitor E. [UNESP]
de Abreu, Luiz Carlos
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro Universitário Saúde ABC
Centro Universitário Uninorte
Universidade de São Paulo (USP)
University of Limerick
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Martinelli, Patrícia Merly
Sorpreso, Isabel Cristina Esposito
Raimundo, Rodrigo Daminello
de Souza Leal, Osvaldo
Zangirolami-Raimundo, Juliana
de Lima, Marcos Venicius Malveira
Pérez-Riera, Andrés
Pereira, Valdelias Xavier
Elmusharaf, Khalifa
Valenti, Vitor E. [UNESP]
de Abreu, Luiz Carlos
description Heart Rate Variability (HRV) represents cardiac autonomic behavior and have been related to menopausal symptoms, mainly vasomotor symptoms and their imbalance to cardiovascular risk. It is not clear in the literature which index represents this imbalance and what is their involvement with the menopausal state. The aim of this study was to evaluate HRV in menopausal transition and post-menopausal symptoms with different intensities. This cross-sectional study was conducted in Rio Branco, State of Acre, Brazil from October 2016 to July 2017. We used Kupperman-Blatt Menopausal Index (KMI) to measure menopausal symptoms intensity. HRV analysis was performed based on the guidelines of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. HRV is lower in the group with moderate/intense menopausal symptoms compared to mild symptoms. (RMSSD: p = 0.005, Cohen’s d = 0.53, pNN50: p = 0.0004, Cohen’s d = 0.68; HF: p = 0.024, Cohen’s d = 0.44). There was association between HRV and KMI (RMSSD: r = -1.248, p = 0.004; and pNN50: r = -0.615, p: 0.029) in inverse relation to the intensity of vasomotor symptoms in women in TM. In conclusion, HRV was able to distinguish menopausal symptoms, indicating reduced vagal control in women with more intense symptoms.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:24:00Z
2020-12-12T02:24:00Z
2020-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1371/journal.pone.0225866
PLoS ONE, v. 15, n. 1, 2020.
1932-6203
http://hdl.handle.net/11449/201098
10.1371/journal.pone.0225866
2-s2.0-85077940738
url http://dx.doi.org/10.1371/journal.pone.0225866
http://hdl.handle.net/11449/201098
identifier_str_mv PLoS ONE, v. 15, n. 1, 2020.
1932-6203
10.1371/journal.pone.0225866
2-s2.0-85077940738
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS ONE
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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