Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó

Detalhes bibliográficos
Autor(a) principal: Carbinatto, F. M. [UNESP]
Data de Publicação: 2011
Outros Autores: Castro, Ana Doris de [UNESP], Oliveira, Anselmo Gomes de [UNESP], Silva, Jr.
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/1267
http://hdl.handle.net/11449/72801
Resumo: Gymnema sylvestre extract (GSE) is a plant product widely used as an adjuvant in the treatment of diabetes mellitus and commercially available as a powder. Owing to its low flowability, the manufacturing of hard gelatin capsules containing GSE faces specific problems. The purpose of this study was to investigate the best excipient (starch, lactose or microcrystalline cellulose) for hard gelatin capsules containing GSE. The technological properties such us bulk density (ρβ); tapped density (ρt); inter-particle porosity (Ie); Carr index (CI); Hausner ratio (HR); loss on drying (%LOD) and particle size distribution (%Pf) of the various GSE mixtures were investigated with the aim of identifying the best excipient. The need for lubricants (talc/magnesium stearate) was also assessed. GSE was characterized as a fine powder with more than 50% of its particles between 0.149mm to 0.250mm; furthermore, CI=25.6%; RH=1.3 and Ie = 25.6% and, as expected with such properties, it showed poor flowability. All the excipients investigated were able to change the technological properties of GSE and the powder mixture containing microcrystalline cellulose gave the best results.
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spelling Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em póPreformulation studies of Gymnema sylvestre extract powder formulation for hard gelatin capsulesGymnema sylvestreHard gelatin capsulesPreformulation studiesSolid dosage formsTechnological propertiesGymnema sylvestre extractlactosemagnesium stearatemicrocrystalline cellulosestarchtalcbulk densitycapsule fillingcomparative effectivenessdrug capsuledrug coatingdrug distributiondrug formulationdrug synthesisintermethod comparisonnonhumanparticle sizeporosityGymnema sylvestre extract (GSE) is a plant product widely used as an adjuvant in the treatment of diabetes mellitus and commercially available as a powder. Owing to its low flowability, the manufacturing of hard gelatin capsules containing GSE faces specific problems. The purpose of this study was to investigate the best excipient (starch, lactose or microcrystalline cellulose) for hard gelatin capsules containing GSE. The technological properties such us bulk density (ρβ); tapped density (ρt); inter-particle porosity (Ie); Carr index (CI); Hausner ratio (HR); loss on drying (%LOD) and particle size distribution (%Pf) of the various GSE mixtures were investigated with the aim of identifying the best excipient. The need for lubricants (talc/magnesium stearate) was also assessed. GSE was characterized as a fine powder with more than 50% of its particles between 0.149mm to 0.250mm; furthermore, CI=25.6%; RH=1.3 and Ie = 25.6% and, as expected with such properties, it showed poor flowability. All the excipients investigated were able to change the technological properties of GSE and the powder mixture containing microcrystalline cellulose gave the best results.Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó O extrato seco de Gymnema sylvestre (EGS) é um produto fitoterápico amplamente utilizado como adjuvante no tratamento da diabetes, sendo comercializado na forma de pó. O objetivo do presente estudo foi investigar a influência da adição de adjuvantes (amido, lactose ou celulose microcristalina) à formulação para a preparação de cápsulas gelatinosas duras contendo o EGS. As propriedades tecnológicas como densidade aparente (Da), densidade aparente de compactação (Dc), porosidade interparticulas (Ie), Índice de Carr (IC), Fator de Hausner (FH), perda por dessecação (PD%) e análise do tamanho de partículas (%Pf) das diferentes misturas preparadas foram investigadas com o objetivo de escolher o melhor excipiente. A necessidade de agentes lubrificantes (talco/estearato de magnésio) também foi avaliada. O EGS foi caracterizado como um pó fino, com mais de 50% do material particulado compreendido entre 0,149-0,250mm; IC=25,6%; FH=1,3 and Ie = 25,6%, o que justifica seu fluxo pobre. Todos os excipientes testados foram capazes de modificar as propriedades tecnológicas do EGS, sendo a mistura de pós que apresentou melhores resultados aquela obtida com a adição de celulose microcristalina.Faculdade de Ciências Farmacêuticas Unesp, Araraquara-SPDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Unesp, Araraquara-SPCentro de Ciências da Saúde Universidade Federal do Rio Grande do Norte-UFRN Departamento de Farmácia, Av. Coronel Gustavo Cordeiro de Farias s/n, Petrópolis, CEP.59010-180 Natal-RNFaculdade de Ciências Farmacêuticas Unesp, Araraquara-SPDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Unesp, Araraquara-SPUniversidade Estadual Paulista (Unesp)Universidade Federal do Rio Grande do Norte (UFRN)Carbinatto, F. M. [UNESP]Castro, Ana Doris de [UNESP]Oliveira, Anselmo Gomes de [UNESP]Silva, Jr.2014-05-27T11:26:07Z2014-05-27T11:26:07Z2011-11-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article175-180http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/1267Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 32, n. 2, p. 175-180, 2011.1808-45322179-443Xhttp://hdl.handle.net/11449/728012-s2.0-808551444229114495952533044Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporRevista de Ciências Farmacêuticas Básica e Aplicada0,131info:eu-repo/semantics/openAccess2024-06-24T13:46:24Zoai:repositorio.unesp.br:11449/72801Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:34:23.716972Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó
Preformulation studies of Gymnema sylvestre extract powder formulation for hard gelatin capsules
title Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó
spellingShingle Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó
Carbinatto, F. M. [UNESP]
Gymnema sylvestre
Hard gelatin capsules
Preformulation studies
Solid dosage forms
Technological properties
Gymnema sylvestre extract
lactose
magnesium stearate
microcrystalline cellulose
starch
talc
bulk density
capsule filling
comparative effectiveness
drug capsule
drug coating
drug distribution
drug formulation
drug synthesis
intermethod comparison
nonhuman
particle size
porosity
title_short Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó
title_full Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó
title_fullStr Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó
title_full_unstemmed Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó
title_sort Estudos de pré-formulação de cápsulas gelatinosas duras contendo formulação de extrato de Gymnema sylvestre em pó
author Carbinatto, F. M. [UNESP]
author_facet Carbinatto, F. M. [UNESP]
Castro, Ana Doris de [UNESP]
Oliveira, Anselmo Gomes de [UNESP]
Silva, Jr.
author_role author
author2 Castro, Ana Doris de [UNESP]
Oliveira, Anselmo Gomes de [UNESP]
Silva, Jr.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal do Rio Grande do Norte (UFRN)
dc.contributor.author.fl_str_mv Carbinatto, F. M. [UNESP]
Castro, Ana Doris de [UNESP]
Oliveira, Anselmo Gomes de [UNESP]
Silva, Jr.
dc.subject.por.fl_str_mv Gymnema sylvestre
Hard gelatin capsules
Preformulation studies
Solid dosage forms
Technological properties
Gymnema sylvestre extract
lactose
magnesium stearate
microcrystalline cellulose
starch
talc
bulk density
capsule filling
comparative effectiveness
drug capsule
drug coating
drug distribution
drug formulation
drug synthesis
intermethod comparison
nonhuman
particle size
porosity
topic Gymnema sylvestre
Hard gelatin capsules
Preformulation studies
Solid dosage forms
Technological properties
Gymnema sylvestre extract
lactose
magnesium stearate
microcrystalline cellulose
starch
talc
bulk density
capsule filling
comparative effectiveness
drug capsule
drug coating
drug distribution
drug formulation
drug synthesis
intermethod comparison
nonhuman
particle size
porosity
description Gymnema sylvestre extract (GSE) is a plant product widely used as an adjuvant in the treatment of diabetes mellitus and commercially available as a powder. Owing to its low flowability, the manufacturing of hard gelatin capsules containing GSE faces specific problems. The purpose of this study was to investigate the best excipient (starch, lactose or microcrystalline cellulose) for hard gelatin capsules containing GSE. The technological properties such us bulk density (ρβ); tapped density (ρt); inter-particle porosity (Ie); Carr index (CI); Hausner ratio (HR); loss on drying (%LOD) and particle size distribution (%Pf) of the various GSE mixtures were investigated with the aim of identifying the best excipient. The need for lubricants (talc/magnesium stearate) was also assessed. GSE was characterized as a fine powder with more than 50% of its particles between 0.149mm to 0.250mm; furthermore, CI=25.6%; RH=1.3 and Ie = 25.6% and, as expected with such properties, it showed poor flowability. All the excipients investigated were able to change the technological properties of GSE and the powder mixture containing microcrystalline cellulose gave the best results.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-15
2014-05-27T11:26:07Z
2014-05-27T11:26:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/1267
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 32, n. 2, p. 175-180, 2011.
1808-4532
2179-443X
http://hdl.handle.net/11449/72801
2-s2.0-80855144422
9114495952533044
url http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/1267
http://hdl.handle.net/11449/72801
identifier_str_mv Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 32, n. 2, p. 175-180, 2011.
1808-4532
2179-443X
2-s2.0-80855144422
9114495952533044
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv Revista de Ciências Farmacêuticas Básica e Aplicada
0,131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 175-180
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129438971330560

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