Curcumin photodynamic effect in the treatment of the induced periodontitis in rats

• Autor(a) principal: Theodoro, Letícia Helena [UNESP]
• Data de Publicação: 2017
• Outros Autores: Ferro-Alves, Marcio Luiz [UNESP], Longo, Mariéllen [UNESP], Nuernberg, Marta Aparecida Alberton [UNESP], Ferreira, Renata Pironato [UNESP], Andreati, Adriele [UNESP], Ervolino, Edilson [UNESP], Duque, Cristiane [UNESP], Garcia, Valdir Gouveia [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1007/s10103-017-2261-3; http://hdl.handle.net/11449/174841
• topic: Curcumin; Periodontitis; Photochemotherapy; Rats

This study assessed the effect of curcumin as a photosensitizer in antimicrobial photodynamic therapy (aPDT) for the treatment of induced periodontitis in rats. Periodontitis was induced via a ligature around the mandibular first molar on the left side of 96 rats. The ligature was removed 7 days later, and the animals were randomized into four groups: NT, no local treatment; CUR, irrigation with curcumin solution (40 μM); LED, irradiation with a light-emitting diode (LED, InGaN, 465–485 nm, 200 mW/cm2, 60 s); and aPDT, irrigation with curcumin solution (40 μM) followed by irradiation with LED. Eight animals from each group were euthanized at 7, 15, and 30 days post-treatment. Treatments were assessed using alveolar bone loss (ABL) in the furcation region using histological, histometric, and immunohistochemical analyses. Rats treated with aPDT exhibited less ABL at 7 days compared to the NT group, moderate pattern immunolabeling for osteoprotegerin at 30 days, and a pattern of immunolabeling for RANKL from moderate to low. Treatments resulted in smaller numbers of TRAP-positive cells compared to the NT group. aPDT as monotherapy using curcumin as a photosensitizer and LED as the light source was effective in the treatment of induced periodontitis in rats.