Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.6061/clinics/2016(08)10 http://hdl.handle.net/11449/178269 |
Resumo: | OBJECTIVE: The aim of this study was to evaluate the roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients. METHODS: In total, 105 consecutive burn injury patients over 18 years in age who were admitted to the Burn Unit of Bauru State Hospital from January to December 2013 were prospectively evaluated. Upon admission, patient demographic information was recorded and a blood sample was taken for biochemical analysis to identify the presence of the Taql(rs731236) and Bsml(rs1544410) polymorphisms. All of the patients were followed over their hospital stay and mortality was recorded. RESULTS: Eighteen of the patients did not sign the informed consent form, and there were technical problems with genotype analysis for 7 of the patients. Thus, 80 patients (mean age, 42.5�16.1 years) were included in the final analysis. In total, 60% of the patients were male, and 16.3% died during the hospital stay. The genotype frequencies for the Taql polymorphism were 51.25% TT, 41.25% TC and 7.50% CC; for the Bsml polymorphism, they were 51.25% GG, 42.50% GA and 6.25% AA. In logistic regression analysis, after adjustments for age, gender and total body surface burn area, there were no associations between the Taql (OR: 1.575; CI95%: 0.148- 16.745; p=0.706) or Bsml (OR: 1.309; CI95%: 0.128-13.430; p=0.821) polymorphisms and mortality for the burn patients. CONCLUSIONS: Our results suggest that the Taql and Bsml vitamin D receptor gene polymorphisms are not associated with hospital mortality of burn patients. |
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Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patientsBsmlMortalityTaqlVDR PolymorphismVitamin DOBJECTIVE: The aim of this study was to evaluate the roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients. METHODS: In total, 105 consecutive burn injury patients over 18 years in age who were admitted to the Burn Unit of Bauru State Hospital from January to December 2013 were prospectively evaluated. Upon admission, patient demographic information was recorded and a blood sample was taken for biochemical analysis to identify the presence of the Taql(rs731236) and Bsml(rs1544410) polymorphisms. All of the patients were followed over their hospital stay and mortality was recorded. RESULTS: Eighteen of the patients did not sign the informed consent form, and there were technical problems with genotype analysis for 7 of the patients. Thus, 80 patients (mean age, 42.5�16.1 years) were included in the final analysis. In total, 60% of the patients were male, and 16.3% died during the hospital stay. The genotype frequencies for the Taql polymorphism were 51.25% TT, 41.25% TC and 7.50% CC; for the Bsml polymorphism, they were 51.25% GG, 42.50% GA and 6.25% AA. In logistic regression analysis, after adjustments for age, gender and total body surface burn area, there were no associations between the Taql (OR: 1.575; CI95%: 0.148- 16.745; p=0.706) or Bsml (OR: 1.309; CI95%: 0.128-13.430; p=0.821) polymorphisms and mortality for the burn patients. CONCLUSIONS: Our results suggest that the Taql and Bsml vitamin D receptor gene polymorphisms are not associated with hospital mortality of burn patients.Universidade Estadual Paulista – UNESP Faculdade de Medicina de Botucatu Departamento de Medicina InternaInstituto Federal S�o Paulo – IFSP, Campus S�o RoqueUniversidade Estadual Paulista – UNESP Faculdade de Medicina de Botucatu Departamento de Medicina InternaUniversidade Estadual Paulista (Unesp)Instituto Federal S�o Paulo – IFSPNogueira, Glaucia R. [UNESP]Azevedo, Paula S. [UNESP]Polegato, Bertha F. [UNESP]Zornoff, Leonardo A.M. [UNESP]Paiva, Sergio A.R. [UNESP]Nogueira, Celia R. [UNESP]Araujo, Natalia C.Carmona, Bruno H.M.Conde, Sandro J.Minicucci, Marcos F. [UNESP]2018-12-11T17:29:34Z2018-12-11T17:29:34Z2016-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article470-473application/pdfhttp://dx.doi.org/10.6061/clinics/2016(08)10Clinics, v. 71, n. 8, p. 470-473, 2016.1807-5932http://hdl.handle.net/11449/17826910.6061/clinics/2016(08)10S1807-593220160008004702-s2.0-84987668109S1807-59322016000800470.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics0,536info:eu-repo/semantics/openAccess2024-08-14T17:36:42Zoai:repositorio.unesp.br:11449/178269Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:36:42Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients |
title |
Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients |
spellingShingle |
Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients Nogueira, Glaucia R. [UNESP] Bsml Mortality Taql VDR Polymorphism Vitamin D |
title_short |
Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients |
title_full |
Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients |
title_fullStr |
Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients |
title_full_unstemmed |
Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients |
title_sort |
Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients |
author |
Nogueira, Glaucia R. [UNESP] |
author_facet |
Nogueira, Glaucia R. [UNESP] Azevedo, Paula S. [UNESP] Polegato, Bertha F. [UNESP] Zornoff, Leonardo A.M. [UNESP] Paiva, Sergio A.R. [UNESP] Nogueira, Celia R. [UNESP] Araujo, Natalia C. Carmona, Bruno H.M. Conde, Sandro J. Minicucci, Marcos F. [UNESP] |
author_role |
author |
author2 |
Azevedo, Paula S. [UNESP] Polegato, Bertha F. [UNESP] Zornoff, Leonardo A.M. [UNESP] Paiva, Sergio A.R. [UNESP] Nogueira, Celia R. [UNESP] Araujo, Natalia C. Carmona, Bruno H.M. Conde, Sandro J. Minicucci, Marcos F. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Instituto Federal S�o Paulo – IFSP |
dc.contributor.author.fl_str_mv |
Nogueira, Glaucia R. [UNESP] Azevedo, Paula S. [UNESP] Polegato, Bertha F. [UNESP] Zornoff, Leonardo A.M. [UNESP] Paiva, Sergio A.R. [UNESP] Nogueira, Celia R. [UNESP] Araujo, Natalia C. Carmona, Bruno H.M. Conde, Sandro J. Minicucci, Marcos F. [UNESP] |
dc.subject.por.fl_str_mv |
Bsml Mortality Taql VDR Polymorphism Vitamin D |
topic |
Bsml Mortality Taql VDR Polymorphism Vitamin D |
description |
OBJECTIVE: The aim of this study was to evaluate the roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients. METHODS: In total, 105 consecutive burn injury patients over 18 years in age who were admitted to the Burn Unit of Bauru State Hospital from January to December 2013 were prospectively evaluated. Upon admission, patient demographic information was recorded and a blood sample was taken for biochemical analysis to identify the presence of the Taql(rs731236) and Bsml(rs1544410) polymorphisms. All of the patients were followed over their hospital stay and mortality was recorded. RESULTS: Eighteen of the patients did not sign the informed consent form, and there were technical problems with genotype analysis for 7 of the patients. Thus, 80 patients (mean age, 42.5�16.1 years) were included in the final analysis. In total, 60% of the patients were male, and 16.3% died during the hospital stay. The genotype frequencies for the Taql polymorphism were 51.25% TT, 41.25% TC and 7.50% CC; for the Bsml polymorphism, they were 51.25% GG, 42.50% GA and 6.25% AA. In logistic regression analysis, after adjustments for age, gender and total body surface burn area, there were no associations between the Taql (OR: 1.575; CI95%: 0.148- 16.745; p=0.706) or Bsml (OR: 1.309; CI95%: 0.128-13.430; p=0.821) polymorphisms and mortality for the burn patients. CONCLUSIONS: Our results suggest that the Taql and Bsml vitamin D receptor gene polymorphisms are not associated with hospital mortality of burn patients. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 2018-12-11T17:29:34Z 2018-12-11T17:29:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.6061/clinics/2016(08)10 Clinics, v. 71, n. 8, p. 470-473, 2016. 1807-5932 http://hdl.handle.net/11449/178269 10.6061/clinics/2016(08)10 S1807-59322016000800470 2-s2.0-84987668109 S1807-59322016000800470.pdf |
url |
http://dx.doi.org/10.6061/clinics/2016(08)10 http://hdl.handle.net/11449/178269 |
identifier_str_mv |
Clinics, v. 71, n. 8, p. 470-473, 2016. 1807-5932 10.6061/clinics/2016(08)10 S1807-59322016000800470 2-s2.0-84987668109 S1807-59322016000800470.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinics 0,536 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
470-473 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128198962053120 |