Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients

Detalhes bibliográficos
Autor(a) principal: Nogueira, Glaucia R. [UNESP]
Data de Publicação: 2016
Outros Autores: Azevedo, Paula S. [UNESP], Polegato, Bertha F. [UNESP], Zornoff, Leonardo A.M. [UNESP], Paiva, Sergio A.R. [UNESP], Nogueira, Celia R. [UNESP], Araujo, Natalia C., Carmona, Bruno H.M., Conde, Sandro J., Minicucci, Marcos F. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.6061/clinics/2016(08)10
http://hdl.handle.net/11449/178269
Resumo: OBJECTIVE: The aim of this study was to evaluate the roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients. METHODS: In total, 105 consecutive burn injury patients over 18 years in age who were admitted to the Burn Unit of Bauru State Hospital from January to December 2013 were prospectively evaluated. Upon admission, patient demographic information was recorded and a blood sample was taken for biochemical analysis to identify the presence of the Taql(rs731236) and Bsml(rs1544410) polymorphisms. All of the patients were followed over their hospital stay and mortality was recorded. RESULTS: Eighteen of the patients did not sign the informed consent form, and there were technical problems with genotype analysis for 7 of the patients. Thus, 80 patients (mean age, 42.5�16.1 years) were included in the final analysis. In total, 60% of the patients were male, and 16.3% died during the hospital stay. The genotype frequencies for the Taql polymorphism were 51.25% TT, 41.25% TC and 7.50% CC; for the Bsml polymorphism, they were 51.25% GG, 42.50% GA and 6.25% AA. In logistic regression analysis, after adjustments for age, gender and total body surface burn area, there were no associations between the Taql (OR: 1.575; CI95%: 0.148- 16.745; p=0.706) or Bsml (OR: 1.309; CI95%: 0.128-13.430; p=0.821) polymorphisms and mortality for the burn patients. CONCLUSIONS: Our results suggest that the Taql and Bsml vitamin D receptor gene polymorphisms are not associated with hospital mortality of burn patients.
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spelling Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patientsBsmlMortalityTaqlVDR PolymorphismVitamin DOBJECTIVE: The aim of this study was to evaluate the roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients. METHODS: In total, 105 consecutive burn injury patients over 18 years in age who were admitted to the Burn Unit of Bauru State Hospital from January to December 2013 were prospectively evaluated. Upon admission, patient demographic information was recorded and a blood sample was taken for biochemical analysis to identify the presence of the Taql(rs731236) and Bsml(rs1544410) polymorphisms. All of the patients were followed over their hospital stay and mortality was recorded. RESULTS: Eighteen of the patients did not sign the informed consent form, and there were technical problems with genotype analysis for 7 of the patients. Thus, 80 patients (mean age, 42.5�16.1 years) were included in the final analysis. In total, 60% of the patients were male, and 16.3% died during the hospital stay. The genotype frequencies for the Taql polymorphism were 51.25% TT, 41.25% TC and 7.50% CC; for the Bsml polymorphism, they were 51.25% GG, 42.50% GA and 6.25% AA. In logistic regression analysis, after adjustments for age, gender and total body surface burn area, there were no associations between the Taql (OR: 1.575; CI95%: 0.148- 16.745; p=0.706) or Bsml (OR: 1.309; CI95%: 0.128-13.430; p=0.821) polymorphisms and mortality for the burn patients. CONCLUSIONS: Our results suggest that the Taql and Bsml vitamin D receptor gene polymorphisms are not associated with hospital mortality of burn patients.Universidade Estadual Paulista – UNESP Faculdade de Medicina de Botucatu Departamento de Medicina InternaInstituto Federal S�o Paulo – IFSP, Campus S�o RoqueUniversidade Estadual Paulista – UNESP Faculdade de Medicina de Botucatu Departamento de Medicina InternaUniversidade Estadual Paulista (Unesp)Instituto Federal S�o Paulo – IFSPNogueira, Glaucia R. [UNESP]Azevedo, Paula S. [UNESP]Polegato, Bertha F. [UNESP]Zornoff, Leonardo A.M. [UNESP]Paiva, Sergio A.R. [UNESP]Nogueira, Celia R. [UNESP]Araujo, Natalia C.Carmona, Bruno H.M.Conde, Sandro J.Minicucci, Marcos F. [UNESP]2018-12-11T17:29:34Z2018-12-11T17:29:34Z2016-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article470-473application/pdfhttp://dx.doi.org/10.6061/clinics/2016(08)10Clinics, v. 71, n. 8, p. 470-473, 2016.1807-5932http://hdl.handle.net/11449/17826910.6061/clinics/2016(08)10S1807-593220160008004702-s2.0-84987668109S1807-59322016000800470.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics0,536info:eu-repo/semantics/openAccess2024-08-14T17:36:42Zoai:repositorio.unesp.br:11449/178269Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:36:42Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
title Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
spellingShingle Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
Nogueira, Glaucia R. [UNESP]
Bsml
Mortality
Taql
VDR Polymorphism
Vitamin D
title_short Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
title_full Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
title_fullStr Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
title_full_unstemmed Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
title_sort Roles of the taql and bsml vitamin d receptor gene polymorphisms in hospital mortality of burn patients
author Nogueira, Glaucia R. [UNESP]
author_facet Nogueira, Glaucia R. [UNESP]
Azevedo, Paula S. [UNESP]
Polegato, Bertha F. [UNESP]
Zornoff, Leonardo A.M. [UNESP]
Paiva, Sergio A.R. [UNESP]
Nogueira, Celia R. [UNESP]
Araujo, Natalia C.
Carmona, Bruno H.M.
Conde, Sandro J.
Minicucci, Marcos F. [UNESP]
author_role author
author2 Azevedo, Paula S. [UNESP]
Polegato, Bertha F. [UNESP]
Zornoff, Leonardo A.M. [UNESP]
Paiva, Sergio A.R. [UNESP]
Nogueira, Celia R. [UNESP]
Araujo, Natalia C.
Carmona, Bruno H.M.
Conde, Sandro J.
Minicucci, Marcos F. [UNESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Instituto Federal S�o Paulo – IFSP
dc.contributor.author.fl_str_mv Nogueira, Glaucia R. [UNESP]
Azevedo, Paula S. [UNESP]
Polegato, Bertha F. [UNESP]
Zornoff, Leonardo A.M. [UNESP]
Paiva, Sergio A.R. [UNESP]
Nogueira, Celia R. [UNESP]
Araujo, Natalia C.
Carmona, Bruno H.M.
Conde, Sandro J.
Minicucci, Marcos F. [UNESP]
dc.subject.por.fl_str_mv Bsml
Mortality
Taql
VDR Polymorphism
Vitamin D
topic Bsml
Mortality
Taql
VDR Polymorphism
Vitamin D
description OBJECTIVE: The aim of this study was to evaluate the roles of the Taql and Bsml vitamin D receptor gene polymorphisms in hospital mortality of burn patients. METHODS: In total, 105 consecutive burn injury patients over 18 years in age who were admitted to the Burn Unit of Bauru State Hospital from January to December 2013 were prospectively evaluated. Upon admission, patient demographic information was recorded and a blood sample was taken for biochemical analysis to identify the presence of the Taql(rs731236) and Bsml(rs1544410) polymorphisms. All of the patients were followed over their hospital stay and mortality was recorded. RESULTS: Eighteen of the patients did not sign the informed consent form, and there were technical problems with genotype analysis for 7 of the patients. Thus, 80 patients (mean age, 42.5�16.1 years) were included in the final analysis. In total, 60% of the patients were male, and 16.3% died during the hospital stay. The genotype frequencies for the Taql polymorphism were 51.25% TT, 41.25% TC and 7.50% CC; for the Bsml polymorphism, they were 51.25% GG, 42.50% GA and 6.25% AA. In logistic regression analysis, after adjustments for age, gender and total body surface burn area, there were no associations between the Taql (OR: 1.575; CI95%: 0.148- 16.745; p=0.706) or Bsml (OR: 1.309; CI95%: 0.128-13.430; p=0.821) polymorphisms and mortality for the burn patients. CONCLUSIONS: Our results suggest that the Taql and Bsml vitamin D receptor gene polymorphisms are not associated with hospital mortality of burn patients.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-01
2018-12-11T17:29:34Z
2018-12-11T17:29:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.6061/clinics/2016(08)10
Clinics, v. 71, n. 8, p. 470-473, 2016.
1807-5932
http://hdl.handle.net/11449/178269
10.6061/clinics/2016(08)10
S1807-59322016000800470
2-s2.0-84987668109
S1807-59322016000800470.pdf
url http://dx.doi.org/10.6061/clinics/2016(08)10
http://hdl.handle.net/11449/178269
identifier_str_mv Clinics, v. 71, n. 8, p. 470-473, 2016.
1807-5932
10.6061/clinics/2016(08)10
S1807-59322016000800470
2-s2.0-84987668109
S1807-59322016000800470.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
0,536
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 470-473
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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