Genetic instability in nerve sheath cell tumors
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/223989 |
Resumo: | After in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangementa were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors. |
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spelling |
Genetic instability in nerve sheath cell tumorsAfter in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangementa were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors.Departamento de Genetica Instituto de Biociencias 'Julio de Mesquita Filho', 18618-000 Botucatu, SPDepartamento de Genetica Instituto de Biociencias 'Julio de Mesquita Filho', 18618-000 Botucatu, SPUniversidade Estadual Paulista (UNESP)Aparecida Rainho, C. [UNESP]Casartelli, C. [UNESP]Barbieri-Neto, J. [UNESP]Rogatto, S. R. [UNESP]2022-04-28T19:54:03Z2022-04-28T19:54:03Z1995-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article459-467Brazilian Journal of Genetics, v. 18, n. 3, p. 459-467, 1995.0100-8455http://hdl.handle.net/11449/2239892-s2.0-0028791274Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Geneticsinfo:eu-repo/semantics/openAccess2022-04-28T19:54:03Zoai:repositorio.unesp.br:11449/223989Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:36:17.215786Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genetic instability in nerve sheath cell tumors |
title |
Genetic instability in nerve sheath cell tumors |
spellingShingle |
Genetic instability in nerve sheath cell tumors Aparecida Rainho, C. [UNESP] |
title_short |
Genetic instability in nerve sheath cell tumors |
title_full |
Genetic instability in nerve sheath cell tumors |
title_fullStr |
Genetic instability in nerve sheath cell tumors |
title_full_unstemmed |
Genetic instability in nerve sheath cell tumors |
title_sort |
Genetic instability in nerve sheath cell tumors |
author |
Aparecida Rainho, C. [UNESP] |
author_facet |
Aparecida Rainho, C. [UNESP] Casartelli, C. [UNESP] Barbieri-Neto, J. [UNESP] Rogatto, S. R. [UNESP] |
author_role |
author |
author2 |
Casartelli, C. [UNESP] Barbieri-Neto, J. [UNESP] Rogatto, S. R. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Aparecida Rainho, C. [UNESP] Casartelli, C. [UNESP] Barbieri-Neto, J. [UNESP] Rogatto, S. R. [UNESP] |
description |
After in vitro culture, we analyzed cytogenetically four acoustic nerve neurinomas, one intraspinal neurinoma and one neurofibroma obtained from unrelated patients. Monosomy of chromosomes 22 and 16 was an abnormality common to all cases, followed in frequency by loss of chromosomes 18 (three cases) and chromosomes 8, 17 and 19 (two cases). Trisomy of chromosome 20 was also detected in two cases. Structural rearrangementa were detected at low frequencies, with del(10)(p12) being present in two cases. In addition, we observed cell subpopulations showing a certain degree of genetic instability, reflected by the presence of polyploid cells with inconsistent abnormalities, endoreduplications and telomeric associations resulting in dicentric chromosomes. It is probable that these cytogenetic abnormalities represent some kind of evolutionary advantage for the in vitro progression of nerve sheath tumors. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-01-01 2022-04-28T19:54:03Z 2022-04-28T19:54:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Brazilian Journal of Genetics, v. 18, n. 3, p. 459-467, 1995. 0100-8455 http://hdl.handle.net/11449/223989 2-s2.0-0028791274 |
identifier_str_mv |
Brazilian Journal of Genetics, v. 18, n. 3, p. 459-467, 1995. 0100-8455 2-s2.0-0028791274 |
url |
http://hdl.handle.net/11449/223989 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Genetics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
459-467 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129340286697472 |