Myotoxin Inhibitors
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/978-94-007-6452-1_12 http://hdl.handle.net/11449/245667 |
Resumo: | Myonecrosis is an important medical complication in snake envenoming and, in severe cases, can lead to drastic sequelae, such as inability and permanent tissue loss. Although the traditional serum therapy effectively neutralizes the systemic effects induced by snake venoms, there are some limitations in reversing the local symptoms induced by myotoxins, since they are small- and medium-sized proteins of low immunogenicity. Due to this impairment in current snakebite treatment, there has been an increasing interest in the search for naturally occurring molecules, as well as in the design of synthetic compounds, which are able to inhibit the main pathophysiological effects induced by snake venom PLA(2) and other myotoxins. These inhibitory molecules are mainly obtained from animal blood and plant extracts; however, a diversity of other sources of myotoxin inhibitors has also been described. This chapter aims to provide current information regarding the diversity of natural and synthetic PLA(2) inhibitors described so far. Moreover, a better understanding of the mechanisms of action involved in PLA(2) inhibition may generate perspectives to the use of these molecules leading to the development of novel therapeutic approaches for snakebite management. |
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Myotoxin InhibitorsMyotoxinsPhopholipases A(2)Myotoxin inhibitorsMyonecrosis is an important medical complication in snake envenoming and, in severe cases, can lead to drastic sequelae, such as inability and permanent tissue loss. Although the traditional serum therapy effectively neutralizes the systemic effects induced by snake venoms, there are some limitations in reversing the local symptoms induced by myotoxins, since they are small- and medium-sized proteins of low immunogenicity. Due to this impairment in current snakebite treatment, there has been an increasing interest in the search for naturally occurring molecules, as well as in the design of synthetic compounds, which are able to inhibit the main pathophysiological effects induced by snake venom PLA(2) and other myotoxins. These inhibitory molecules are mainly obtained from animal blood and plant extracts; however, a diversity of other sources of myotoxin inhibitors has also been described. This chapter aims to provide current information regarding the diversity of natural and synthetic PLA(2) inhibitors described so far. Moreover, a better understanding of the mechanisms of action involved in PLA(2) inhibition may generate perspectives to the use of these molecules leading to the development of novel therapeutic approaches for snakebite management.Univ Estadual Paulista Julio de Mesquita Filho UN, Inst Quim Araraquara, Araraquara, SP, BrazilUniv Sao Paulo FCFRP USP, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto, SP, BrazilUniv Sao Paulo FCFRP USP, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, Ribeirao Preto, SP, BrazilUniv Estadual Paulista Julio de Mesquita Filho UN, Inst Quim Araraquara, Araraquara, SP, BrazilSpringerUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Santos-Filho, Norival Alves [UNESP]Silveira, Lucas BlundiBoldrini-Franca, JoharaCruz, L. J.Luo, S.Gopalakrishnakone, P.2023-07-29T12:01:32Z2023-07-29T12:01:32Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article321-349http://dx.doi.org/10.1007/978-94-007-6452-1_12Toxins and Drug Discovery. Dordrecht: Springer, p. 321-349, 2017.2542-761Xhttp://hdl.handle.net/11449/24566710.1007/978-94-007-6452-1_12WOS:000415219600015Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengToxins And Drug Discoveryinfo:eu-repo/semantics/openAccess2024-06-24T14:52:03Zoai:repositorio.unesp.br:11449/245667Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:26:52.494821Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Myotoxin Inhibitors |
title |
Myotoxin Inhibitors |
spellingShingle |
Myotoxin Inhibitors Santos-Filho, Norival Alves [UNESP] Myotoxins Phopholipases A(2) Myotoxin inhibitors |
title_short |
Myotoxin Inhibitors |
title_full |
Myotoxin Inhibitors |
title_fullStr |
Myotoxin Inhibitors |
title_full_unstemmed |
Myotoxin Inhibitors |
title_sort |
Myotoxin Inhibitors |
author |
Santos-Filho, Norival Alves [UNESP] |
author_facet |
Santos-Filho, Norival Alves [UNESP] Silveira, Lucas Blundi Boldrini-Franca, Johara Cruz, L. J. Luo, S. Gopalakrishnakone, P. |
author_role |
author |
author2 |
Silveira, Lucas Blundi Boldrini-Franca, Johara Cruz, L. J. Luo, S. Gopalakrishnakone, P. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Santos-Filho, Norival Alves [UNESP] Silveira, Lucas Blundi Boldrini-Franca, Johara Cruz, L. J. Luo, S. Gopalakrishnakone, P. |
dc.subject.por.fl_str_mv |
Myotoxins Phopholipases A(2) Myotoxin inhibitors |
topic |
Myotoxins Phopholipases A(2) Myotoxin inhibitors |
description |
Myonecrosis is an important medical complication in snake envenoming and, in severe cases, can lead to drastic sequelae, such as inability and permanent tissue loss. Although the traditional serum therapy effectively neutralizes the systemic effects induced by snake venoms, there are some limitations in reversing the local symptoms induced by myotoxins, since they are small- and medium-sized proteins of low immunogenicity. Due to this impairment in current snakebite treatment, there has been an increasing interest in the search for naturally occurring molecules, as well as in the design of synthetic compounds, which are able to inhibit the main pathophysiological effects induced by snake venom PLA(2) and other myotoxins. These inhibitory molecules are mainly obtained from animal blood and plant extracts; however, a diversity of other sources of myotoxin inhibitors has also been described. This chapter aims to provide current information regarding the diversity of natural and synthetic PLA(2) inhibitors described so far. Moreover, a better understanding of the mechanisms of action involved in PLA(2) inhibition may generate perspectives to the use of these molecules leading to the development of novel therapeutic approaches for snakebite management. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2023-07-29T12:01:32Z 2023-07-29T12:01:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/978-94-007-6452-1_12 Toxins and Drug Discovery. Dordrecht: Springer, p. 321-349, 2017. 2542-761X http://hdl.handle.net/11449/245667 10.1007/978-94-007-6452-1_12 WOS:000415219600015 |
url |
http://dx.doi.org/10.1007/978-94-007-6452-1_12 http://hdl.handle.net/11449/245667 |
identifier_str_mv |
Toxins and Drug Discovery. Dordrecht: Springer, p. 321-349, 2017. 2542-761X 10.1007/978-94-007-6452-1_12 WOS:000415219600015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Toxins And Drug Discovery |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
321-349 |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129522004918272 |