Lymphomatoid Papulosis Type E Affecting the Palate: A Detailed Case Report and Review of Literature

• Autor(a) principal: Silveira, Heitor Albergoni [UNESP]
• Data de Publicação: 2023
• Outros Autores: Ragusa Silva, Paula Verona [UNESP], Pimentel, Bruna Gonçalves, Nogueira, Gustavo Milhomens, Chahud, Fernando, Brunaldi, Mariângela Ottoboni, León, Jorge Esquiche
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1097/DAD.0000000000002405; http://hdl.handle.net/11449/248718
• topic: angioinvasive; differential diagnosis; lymphoma; lymphomatoid papulosis type E; lymphoproliferative disorder; oral cavity

Lymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30+lymphoproliferative disorders, characterized by chronic, recurrent, self-healing papules, small nodules, or ulcers. The clinicopathological features of LyP can mimic overt lymphomas. To date, about 27 intraoral LyP cases have been reported. Of them, only 2 cases were diagnosed as angioinvasive LyP (type E). Herein, we report a 24-year-old Brazilian man who presented a large ulcerated lesion on the hard palate with rapid evolution. Remarkably, there was no involvement of the skin or other mucous membranes. Microscopy revealed a lymphoid infiltrate constituted by medium-sized to large atypical cells, with angiocentric and angiodestructive features. The atypical cells showed immunopositivity for CD3, CD8, CD30, CD56, granzyme B, perforin, and focally for MUM1/IRF4. Ki-67 highlighted almost all atypical lymphoid cells, whereas EBER1/2 was negative. After 2 months of follow-up, the lesion healed completely. Although rare, LyP type E should be included in the differential diagnosis of oral ulcers.