The effects of ethyl-2-cyanoacrylate and butyl-2-cyanoacrylate in the process of bone healing in rats. A controlled experimental study

• Autor(a) principal: Palacio, Evandro Pereira
• Data de Publicação: 2018
• Outros Autores: Pereira, Gilberto José Cação, Silvares, Paulo Roberto De Almeida, Stasi, Gabriel Guimarães Di, Staut, Caio De Andrade, Sardenberg, Trajano
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1016/j.rboe.2017.11.010
• Texto Completo: http://dx.doi.org/10.1016/j.rboe.2017.11.010; http://hdl.handle.net/11449/158111
• topic: Cyanoacrylates; Tissue adhesives; Fractures, bones; Fracture healing; Cianoacrilatos; Adesivos teciduais; Fraturas ósseas; Consolidação da fratura

ABSTRACTObjective:Synthetic adhesives are used by various medical specialties, especially in surgery; however, studies reporting their use in orthopedic practice are scarce. The aim of this study was to compare the results in using ethyl-2-cyanoacrylate or butyl-2-cyanoacrylate in the treatment of fractures in rats.Methods:This was an experimental prospective controlled study in 90 rats, with humerus, femur, and tibia fractures, treated with ethyl-2-cyanoacrylate (SB group; n = 45) or butyl-2-cyanoacrylate (HA group; n = 45). Biomechanical and histomorphometric analyses were performed at three different moments (60, 120, and 180 days); besides a clinical study performed weekly by measurement of the animals body mass.Results:No differences were observed regarding body mass (p = 0.07). In both groups, there were no significant differences regarding maximum load (p = 0.6), yield point strength (p = 0.6), and stiffness coefficient (p = 0.4) of the femurs. The same was observed in tibias for maximum load (p = 0.4), yield point strength (p = 0.7), and stiffness coefficient (p = 0.6). The humerus from both groups had similar bone callus area (p = 0.66). In both groups, there were no statistical differences related to inflammatory cells (p = 0.4), osteoblasts (p = 0.2), and osteoclasts (p = 0.2).Conclusion:Ethyl-2-cyanoacrylate was more effective than butyl-2-cyanoacrylate in the treatment of fractures in rats.