Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/1098-2264(2000)9999:9999< http://hdl.handle.net/11449/224212 |
Resumo: | Comparative genomic hybridization analysis was performed for identification of chromosomal imbalances in 23 samples of fibroadenomas of the breast. Chromosomal gains rather than losses were a feature of these lesions. Only two cases with a familial and/or previous history of breast lesions had gain of 1q or 16q as the sole abnormality. The most frequently overrepresented segments were 5p14 (10/23 cases), 5q34-qter (6/23 cases), 13q32-qter (6/23 cases), 10q25-qter (5/23 cases), and 18q22 (4/23 cases). Some of these regions have previously been associated with breast carcinoma, but this study indicates that gain of these regions can also occur in benign breast lesions. Our findings may provide a basis for conducting further investigations to locate and identify genes associated with proliferation that may be involved in the early steps of tumorigenesis of the breast. (C) 2001 Wiley-Liss, Inc. |
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Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breastComparative genomic hybridization analysis was performed for identification of chromosomal imbalances in 23 samples of fibroadenomas of the breast. Chromosomal gains rather than losses were a feature of these lesions. Only two cases with a familial and/or previous history of breast lesions had gain of 1q or 16q as the sole abnormality. The most frequently overrepresented segments were 5p14 (10/23 cases), 5q34-qter (6/23 cases), 13q32-qter (6/23 cases), 10q25-qter (5/23 cases), and 18q22 (4/23 cases). Some of these regions have previously been associated with breast carcinoma, but this study indicates that gain of these regions can also occur in benign breast lesions. Our findings may provide a basis for conducting further investigations to locate and identify genes associated with proliferation that may be involved in the early steps of tumorigenesis of the breast. (C) 2001 Wiley-Liss, Inc.Departamento de Genetica IB, UNESP, Botucatu, SPAmaral Carvalho Hospital Jau, Sao pauloDepartment of Pathology Faculty of Medicine-USP-Ribeirao Preto Sao PauloDepartment of Laboratory Medicine and Pathobiology Faculty of Medicine Ontario Cancer Institute, University of Toronto/Princess Margaret Hospital, Toronto, OntarioDepartamento de Genetica IB, UNESP, Botucatu, SPUniversidade Estadual Paulista (UNESP)Jau, Sao pauloUniversidade de São Paulo (USP)Ontario Cancer InstituteOjopi, Elida Paula Benquique [UNESP]Rogatto, Silvia Regina [UNESP]Caldeira, Jose Roberto FiagroBarbieri-Neto, JoseSquire, Jeremy A.2022-04-28T19:55:19Z2022-04-28T19:55:19Z2001-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article25-31http://dx.doi.org/10.1002/1098-2264(2000)9999:9999<Genes Chromosomes and Cancer, v. 30, n. 1, p. 25-31, 2001.1045-2257http://hdl.handle.net/11449/22421210.1002/1098-2264(2000)9999:9999<2-s2.0-0035212658Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenes Chromosomes and Cancerinfo:eu-repo/semantics/openAccess2022-04-28T19:55:20Zoai:repositorio.unesp.br:11449/224212Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:52:20.235656Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast |
title |
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast |
spellingShingle |
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast Ojopi, Elida Paula Benquique [UNESP] |
title_short |
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast |
title_full |
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast |
title_fullStr |
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast |
title_full_unstemmed |
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast |
title_sort |
Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast |
author |
Ojopi, Elida Paula Benquique [UNESP] |
author_facet |
Ojopi, Elida Paula Benquique [UNESP] Rogatto, Silvia Regina [UNESP] Caldeira, Jose Roberto Fiagro Barbieri-Neto, Jose Squire, Jeremy A. |
author_role |
author |
author2 |
Rogatto, Silvia Regina [UNESP] Caldeira, Jose Roberto Fiagro Barbieri-Neto, Jose Squire, Jeremy A. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Jau, Sao paulo Universidade de São Paulo (USP) Ontario Cancer Institute |
dc.contributor.author.fl_str_mv |
Ojopi, Elida Paula Benquique [UNESP] Rogatto, Silvia Regina [UNESP] Caldeira, Jose Roberto Fiagro Barbieri-Neto, Jose Squire, Jeremy A. |
description |
Comparative genomic hybridization analysis was performed for identification of chromosomal imbalances in 23 samples of fibroadenomas of the breast. Chromosomal gains rather than losses were a feature of these lesions. Only two cases with a familial and/or previous history of breast lesions had gain of 1q or 16q as the sole abnormality. The most frequently overrepresented segments were 5p14 (10/23 cases), 5q34-qter (6/23 cases), 13q32-qter (6/23 cases), 10q25-qter (5/23 cases), and 18q22 (4/23 cases). Some of these regions have previously been associated with breast carcinoma, but this study indicates that gain of these regions can also occur in benign breast lesions. Our findings may provide a basis for conducting further investigations to locate and identify genes associated with proliferation that may be involved in the early steps of tumorigenesis of the breast. (C) 2001 Wiley-Liss, Inc. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-01-01 2022-04-28T19:55:19Z 2022-04-28T19:55:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/1098-2264(2000)9999:9999< Genes Chromosomes and Cancer, v. 30, n. 1, p. 25-31, 2001. 1045-2257 http://hdl.handle.net/11449/224212 10.1002/1098-2264(2000)9999:9999< 2-s2.0-0035212658 |
url |
http://dx.doi.org/10.1002/1098-2264(2000)9999:9999< http://hdl.handle.net/11449/224212 |
identifier_str_mv |
Genes Chromosomes and Cancer, v. 30, n. 1, p. 25-31, 2001. 1045-2257 10.1002/1098-2264(2000)9999:9999< 2-s2.0-0035212658 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genes Chromosomes and Cancer |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
25-31 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129368019435520 |