Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.biopha.2023.114626 http://hdl.handle.net/11449/249809 |
Resumo: | Propolis is a natural product has many biological properties of clinical interest, such as anti-inflammatory and antioxidant. Considering that people living with HIV/aids (PLWHA) on effective combined antiretroviral therapy (cART) present early aging due to an intense immune activation, inflammation, and redox imbalance, propolis consumption could offer a benefit to such patients. This double-blind longitudinal study evaluated whether Brazilian green propolis pills intake (500 mg/day for three months) would decrease the oxidative stress of virological suppressed HIV-individuals. To compare each group (propolis, n = 20 versus placebo, n = 20) in both moments (M0, before and M1, after the intervention), the following markers were assessed: plasma malondialdehyde (MDA), carbonylation, total oxide nitric, total antioxidant capacity (TAP), superoxide dismutase, catalase, and NFkB and NRF2 gene expression. Data were analyzed using Poisson, Gamma distribution and ANOVA followed by Tukey-Kramer. The groups were homogeneous regarding age, gender, time of diagnosis/ treatment, cART scheme, CD4+ T cell count, and no changes were observed in the diet food, or patients’ lifestyles. A decreased MDA concentration was seen in the propolis group (M0 = 0.24 ± 0.13, M1 = 0.20 ± 0.10 protein nmol/mg; p = 0.005) as well as a slight but non-significant increase of TAP (M0 = 49.07 ± 13.26, M1 = 52.27 ± 14.86%; p = 0.06). One may conclude that propolis promoted a lower lipid peroxidation and improved the antioxidant system, suggesting that its use may be beneficial to PLWHA in an attempt to contain the intense inflammatory and oxidant activity. |
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Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trialAntioxidantHIVMalondialdehydeNatural productOxidative stressPropolisRedoxPropolis is a natural product has many biological properties of clinical interest, such as anti-inflammatory and antioxidant. Considering that people living with HIV/aids (PLWHA) on effective combined antiretroviral therapy (cART) present early aging due to an intense immune activation, inflammation, and redox imbalance, propolis consumption could offer a benefit to such patients. This double-blind longitudinal study evaluated whether Brazilian green propolis pills intake (500 mg/day for three months) would decrease the oxidative stress of virological suppressed HIV-individuals. To compare each group (propolis, n = 20 versus placebo, n = 20) in both moments (M0, before and M1, after the intervention), the following markers were assessed: plasma malondialdehyde (MDA), carbonylation, total oxide nitric, total antioxidant capacity (TAP), superoxide dismutase, catalase, and NFkB and NRF2 gene expression. Data were analyzed using Poisson, Gamma distribution and ANOVA followed by Tukey-Kramer. The groups were homogeneous regarding age, gender, time of diagnosis/ treatment, cART scheme, CD4+ T cell count, and no changes were observed in the diet food, or patients’ lifestyles. A decreased MDA concentration was seen in the propolis group (M0 = 0.24 ± 0.13, M1 = 0.20 ± 0.10 protein nmol/mg; p = 0.005) as well as a slight but non-significant increase of TAP (M0 = 49.07 ± 13.26, M1 = 52.27 ± 14.86%; p = 0.06). One may conclude that propolis promoted a lower lipid peroxidation and improved the antioxidant system, suggesting that its use may be beneficial to PLWHA in an attempt to contain the intense inflammatory and oxidant activity.Institute of Biosciences São Paulo State University (UNESP), SPBotucatu Medical School UNESP, SPApis Flora Industrial e Comercial Ltda. R&D Department, SPInstitute of Biosciences São Paulo State University (UNESP), SPBotucatu Medical School UNESP, SPUniversidade Estadual Paulista (UNESP)R&D DepartmentTasca, Karen Ingrid [UNESP]Conte, Fernanda Lopes [UNESP]Correa, Camila Renata [UNESP]Santiago, Karina Basso [UNESP]Cardoso, Eliza de Oliveira [UNESP]Manfio, Vanessa Martinez [UNESP]Garcia, Jessica Leite [UNESP]Berretta, Andresa AparecidaSartori, Arthur Alves [UNESP]Honorio, Mariana da Silva [UNESP]Souza, Lenice do Rosário [UNESP]Sforcin, José Maurício [UNESP]2023-07-29T16:09:50Z2023-07-29T16:09:50Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.biopha.2023.114626Biomedicine and Pharmacotherapy, v. 162.1950-60070753-3322http://hdl.handle.net/11449/24980910.1016/j.biopha.2023.1146262-s2.0-85151338689Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiomedicine and Pharmacotherapyinfo:eu-repo/semantics/openAccess2023-07-29T16:09:50Zoai:repositorio.unesp.br:11449/249809Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T16:09:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial |
title |
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial |
spellingShingle |
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial Tasca, Karen Ingrid [UNESP] Antioxidant HIV Malondialdehyde Natural product Oxidative stress Propolis Redox |
title_short |
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial |
title_full |
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial |
title_fullStr |
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial |
title_full_unstemmed |
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial |
title_sort |
Propolis consumption by asymptomatic HIV-individuals: Better redox state? A prospective, randomized, double-blind, placebo-controlled trial |
author |
Tasca, Karen Ingrid [UNESP] |
author_facet |
Tasca, Karen Ingrid [UNESP] Conte, Fernanda Lopes [UNESP] Correa, Camila Renata [UNESP] Santiago, Karina Basso [UNESP] Cardoso, Eliza de Oliveira [UNESP] Manfio, Vanessa Martinez [UNESP] Garcia, Jessica Leite [UNESP] Berretta, Andresa Aparecida Sartori, Arthur Alves [UNESP] Honorio, Mariana da Silva [UNESP] Souza, Lenice do Rosário [UNESP] Sforcin, José Maurício [UNESP] |
author_role |
author |
author2 |
Conte, Fernanda Lopes [UNESP] Correa, Camila Renata [UNESP] Santiago, Karina Basso [UNESP] Cardoso, Eliza de Oliveira [UNESP] Manfio, Vanessa Martinez [UNESP] Garcia, Jessica Leite [UNESP] Berretta, Andresa Aparecida Sartori, Arthur Alves [UNESP] Honorio, Mariana da Silva [UNESP] Souza, Lenice do Rosário [UNESP] Sforcin, José Maurício [UNESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) R&D Department |
dc.contributor.author.fl_str_mv |
Tasca, Karen Ingrid [UNESP] Conte, Fernanda Lopes [UNESP] Correa, Camila Renata [UNESP] Santiago, Karina Basso [UNESP] Cardoso, Eliza de Oliveira [UNESP] Manfio, Vanessa Martinez [UNESP] Garcia, Jessica Leite [UNESP] Berretta, Andresa Aparecida Sartori, Arthur Alves [UNESP] Honorio, Mariana da Silva [UNESP] Souza, Lenice do Rosário [UNESP] Sforcin, José Maurício [UNESP] |
dc.subject.por.fl_str_mv |
Antioxidant HIV Malondialdehyde Natural product Oxidative stress Propolis Redox |
topic |
Antioxidant HIV Malondialdehyde Natural product Oxidative stress Propolis Redox |
description |
Propolis is a natural product has many biological properties of clinical interest, such as anti-inflammatory and antioxidant. Considering that people living with HIV/aids (PLWHA) on effective combined antiretroviral therapy (cART) present early aging due to an intense immune activation, inflammation, and redox imbalance, propolis consumption could offer a benefit to such patients. This double-blind longitudinal study evaluated whether Brazilian green propolis pills intake (500 mg/day for three months) would decrease the oxidative stress of virological suppressed HIV-individuals. To compare each group (propolis, n = 20 versus placebo, n = 20) in both moments (M0, before and M1, after the intervention), the following markers were assessed: plasma malondialdehyde (MDA), carbonylation, total oxide nitric, total antioxidant capacity (TAP), superoxide dismutase, catalase, and NFkB and NRF2 gene expression. Data were analyzed using Poisson, Gamma distribution and ANOVA followed by Tukey-Kramer. The groups were homogeneous regarding age, gender, time of diagnosis/ treatment, cART scheme, CD4+ T cell count, and no changes were observed in the diet food, or patients’ lifestyles. A decreased MDA concentration was seen in the propolis group (M0 = 0.24 ± 0.13, M1 = 0.20 ± 0.10 protein nmol/mg; p = 0.005) as well as a slight but non-significant increase of TAP (M0 = 49.07 ± 13.26, M1 = 52.27 ± 14.86%; p = 0.06). One may conclude that propolis promoted a lower lipid peroxidation and improved the antioxidant system, suggesting that its use may be beneficial to PLWHA in an attempt to contain the intense inflammatory and oxidant activity. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T16:09:50Z 2023-07-29T16:09:50Z 2023-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.biopha.2023.114626 Biomedicine and Pharmacotherapy, v. 162. 1950-6007 0753-3322 http://hdl.handle.net/11449/249809 10.1016/j.biopha.2023.114626 2-s2.0-85151338689 |
url |
http://dx.doi.org/10.1016/j.biopha.2023.114626 http://hdl.handle.net/11449/249809 |
identifier_str_mv |
Biomedicine and Pharmacotherapy, v. 162. 1950-6007 0753-3322 10.1016/j.biopha.2023.114626 2-s2.0-85151338689 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biomedicine and Pharmacotherapy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965680009740288 |