Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1758-5996-6-84 http://hdl.handle.net/11449/117326 |
Resumo: | Background: Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.Methods: We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.Results: We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.Conclusions: Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment. |
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Repositório Institucional da UNESP |
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Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed miceHigh-fat dietAdipokinesAdipose tissueInflammationBackground: Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.Methods: We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.Results: We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.Conclusions: Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAINCUniv Fed Sao Paulo, EPM, Dept Fisiol, Sao Paulo, BrazilFac Integradas Coracao Jesus FAINC, Santo Andre, SP, BrazilUniv Estadual Paulista, UNESP, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, SP, BrazilUniv Southern Santa Catarina, Hlth Sci Unit, Lab Exercise Biochem & Physiol, Criciuma, SC, BrazilUniv Fed Sao Paulo, Dept Ciencias Biol, Diadema, SP, BrazilUniv Estadual Paulista, UNESP, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, SP, BrazilFAPESP: 09/14373-8Biomed Central LtdUniversidade Federal de São Paulo (UNIFESP)Fac Integradas Coracao Jesus FAINCUniversidade Estadual Paulista (Unesp)Univ Southern Santa CatarinaMoreno, Mayara FranzoiDe Laquila, RachelOkuda, Marcos HiromuLira, Fabio Santos [UNESP]Morais Honorato de Souza, Gabriel Inacio deSouza, Claudio Teodoro deTelles, Monica MarquesRibeiro, Eliane BeraldiOller do Nascimento, Claudia MariaOyama, Lila Missae2015-03-18T15:55:51Z2015-03-18T15:55:51Z2014-08-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1186/1758-5996-6-84Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 7 p., 2014.1758-5996http://hdl.handle.net/11449/11732610.1186/1758-5996-6-84WOS:000340957000002WOS000340957000002.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDiabetology & Metabolic Syndrome2.4130,943info:eu-repo/semantics/openAccess2024-06-18T17:42:59Zoai:repositorio.unesp.br:11449/117326Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:53:42.733639Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice |
title |
Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice |
spellingShingle |
Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice Moreno, Mayara Franzoi High-fat diet Adipokines Adipose tissue Inflammation |
title_short |
Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice |
title_full |
Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice |
title_fullStr |
Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice |
title_full_unstemmed |
Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice |
title_sort |
Metabolic profile response to administration of epigallocatechin-3-gallate in high-fat-fed mice |
author |
Moreno, Mayara Franzoi |
author_facet |
Moreno, Mayara Franzoi De Laquila, Rachel Okuda, Marcos Hiromu Lira, Fabio Santos [UNESP] Morais Honorato de Souza, Gabriel Inacio de Souza, Claudio Teodoro de Telles, Monica Marques Ribeiro, Eliane Beraldi Oller do Nascimento, Claudia Maria Oyama, Lila Missae |
author_role |
author |
author2 |
De Laquila, Rachel Okuda, Marcos Hiromu Lira, Fabio Santos [UNESP] Morais Honorato de Souza, Gabriel Inacio de Souza, Claudio Teodoro de Telles, Monica Marques Ribeiro, Eliane Beraldi Oller do Nascimento, Claudia Maria Oyama, Lila Missae |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Fac Integradas Coracao Jesus FAINC Universidade Estadual Paulista (Unesp) Univ Southern Santa Catarina |
dc.contributor.author.fl_str_mv |
Moreno, Mayara Franzoi De Laquila, Rachel Okuda, Marcos Hiromu Lira, Fabio Santos [UNESP] Morais Honorato de Souza, Gabriel Inacio de Souza, Claudio Teodoro de Telles, Monica Marques Ribeiro, Eliane Beraldi Oller do Nascimento, Claudia Maria Oyama, Lila Missae |
dc.subject.por.fl_str_mv |
High-fat diet Adipokines Adipose tissue Inflammation |
topic |
High-fat diet Adipokines Adipose tissue Inflammation |
description |
Background: Obesity is associated with increased adipose tissue and glucose intolerance. High-fat diets (HFDs) are known to induce obesity and increase proinflammatory adipokines. The consumption of green tea may improve the health of obese individuals because it contains a potent antioxidant that has effects on body weight, energy expenditure and serum cholesterol concentrations.Methods: We examined the effects of epigallocatechin-3-gallate (EGCG) (50 mg/kg body weight per day) or saline after 30 or 60 days of treatment. Mice were distributed into four groups: 1) NS: normolipidic diet receiving saline; 2) NE: normolipidic diet receiving EGCG; 3) HFS: high-fat diet receiving saline; 4) HFE: high-fat diet receiving EGCG.Results: We observed that administration of a HFD plus EGCG treatment for 60 days reduced delta weight, the relative weights of the mesenteric adipose tissue (MES), retroperitonial adipose tissue (RET), epididymal adipose tissue (EPI), the sum of the adipose tissues (SAT), reduced triacylglycerol (TG) and improved both high-density lipoprotein (HDL) cholesterol levels and the adiponectin/STA ratio when compared with HFS.Conclusions: Our results suggest that the chronic administration of EGCG (60 days) promoted a significant improvement in glucose tolerance, decreased adipose tissue deposits, weight mass, TG and HDL-C only when associated with high-fat diet treatment. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-12 2015-03-18T15:55:51Z 2015-03-18T15:55:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1758-5996-6-84 Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 7 p., 2014. 1758-5996 http://hdl.handle.net/11449/117326 10.1186/1758-5996-6-84 WOS:000340957000002 WOS000340957000002.pdf |
url |
http://dx.doi.org/10.1186/1758-5996-6-84 http://hdl.handle.net/11449/117326 |
identifier_str_mv |
Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 7 p., 2014. 1758-5996 10.1186/1758-5996-6-84 WOS:000340957000002 WOS000340957000002.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Diabetology & Metabolic Syndrome 2.413 0,943 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129136129998848 |