Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fvets.2021.681423 http://hdl.handle.net/11449/231532 |
Resumo: | The control of vampire bat rabies (VBR) in Brazil is based on the culling of Desmodus rotundus and the surveillance of outbreaks caused by D. rotundus in cattle and humans in addition to vaccination of susceptible livestock. The detection of anti-rabies antibodies in vampire bats indicates exposure to the rabies virus, and several studies have reported an increase of these antibodies following experimental infection. However, the dynamics of anti-rabies antibodies in natural populations of D. rotundus remains poorly understood. In this study, we took advantage of recent outbreaks of VBR among livestock in the Sao Paulo region of Brazil to test whether seroprevalence in D. rotundus reflects the incidence of rabies in nearby livestock populations. Sixty-four D. rotundus were captured during and after outbreaks from roost located in municipalities belonging to three regions with different incidences of rabies in herbivores. Sixteen seropositive bats were then kept in captivity for up to 120 days, and their antibodies and virus levels were quantified at different time points using the rapid fluorescent focus inhibition test (RFFIT). Antibody titers were associated with the occurrence of ongoing outbreak, with a higher proportion of bats showing titer >0.5 IU/ml in the region with a recent outbreak. However, low titers were still detected in bats from regions reporting the last outbreak of rabies at least 3 years prior to sampling. This study suggests that serological surveillance of rabies in vampire bats can be used as a tool to evaluate risk of outbreaks in at risk populations of cattle and human. |
id |
UNSP_ffdb900c054fe75b8f64d177db30f4b4 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/231532 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundusantibodiesrabiesRFFITserologyvampire batsvirus neutralizing antibodiesThe control of vampire bat rabies (VBR) in Brazil is based on the culling of Desmodus rotundus and the surveillance of outbreaks caused by D. rotundus in cattle and humans in addition to vaccination of susceptible livestock. The detection of anti-rabies antibodies in vampire bats indicates exposure to the rabies virus, and several studies have reported an increase of these antibodies following experimental infection. However, the dynamics of anti-rabies antibodies in natural populations of D. rotundus remains poorly understood. In this study, we took advantage of recent outbreaks of VBR among livestock in the Sao Paulo region of Brazil to test whether seroprevalence in D. rotundus reflects the incidence of rabies in nearby livestock populations. Sixty-four D. rotundus were captured during and after outbreaks from roost located in municipalities belonging to three regions with different incidences of rabies in herbivores. Sixteen seropositive bats were then kept in captivity for up to 120 days, and their antibodies and virus levels were quantified at different time points using the rapid fluorescent focus inhibition test (RFFIT). Antibody titers were associated with the occurrence of ongoing outbreak, with a higher proportion of bats showing titer >0.5 IU/ml in the region with a recent outbreak. However, low titers were still detected in bats from regions reporting the last outbreak of rabies at least 3 years prior to sampling. This study suggests that serological surveillance of rabies in vampire bats can be used as a tool to evaluate risk of outbreaks in at risk populations of cattle and human.School of Veterinary Medicine and Animal Science São Paulo State University (Unesp)Centro de Investigación para la sustestabilidad Facultad de Ciencias de la vida Universidad Andrés BelloAnimal Health Department Universidad Antonio Narino Cauca PopayanDiagnostics Sector Immunology Laboratory Pasteur Institute of São PauloCentro de Controle de Zoonoses Coordenadoria de vigilância em saúdeSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp)Universidade Estadual Paulista (UNESP)Universidad Andrés BelloUniversidad Antonio Narino Cauca PopayanImmunology Laboratory Pasteur Institute of São PauloCoordenadoria de vigilância em saúdeMegid, Jane [UNESP]Benavides Tala, Julio Andre [UNESP]Belaz Silva, Laís Dário [UNESP]Castro Castro, Fernando Favian [UNESP]Ribeiro, Bruna Letícia Devidé [UNESP]Appolinário, Camila Michele [UNESP]Katz, Iana Suly SantosScheffer, Karin CorrêaSilva, Sandriana RamosRosa, Adriana RuckertBarone, Gisely ToledoAlves Martorelli, Luzia Fátimade Almeida, Marilene Fernandes2022-04-29T08:46:00Z2022-04-29T08:46:00Z2021-09-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fvets.2021.681423Frontiers in Veterinary Science, v. 8.2297-1769http://hdl.handle.net/11449/23153210.3389/fvets.2021.6814232-s2.0-85117140162Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Veterinary Scienceinfo:eu-repo/semantics/openAccess2022-04-29T08:46:01Zoai:repositorio.unesp.br:11449/231532Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:06:35.566277Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus |
title |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus |
spellingShingle |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus Megid, Jane [UNESP] antibodies rabies RFFIT serology vampire bats virus neutralizing antibodies |
title_short |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus |
title_full |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus |
title_fullStr |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus |
title_full_unstemmed |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus |
title_sort |
Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus |
author |
Megid, Jane [UNESP] |
author_facet |
Megid, Jane [UNESP] Benavides Tala, Julio Andre [UNESP] Belaz Silva, Laís Dário [UNESP] Castro Castro, Fernando Favian [UNESP] Ribeiro, Bruna Letícia Devidé [UNESP] Appolinário, Camila Michele [UNESP] Katz, Iana Suly Santos Scheffer, Karin Corrêa Silva, Sandriana Ramos Rosa, Adriana Ruckert Barone, Gisely Toledo Alves Martorelli, Luzia Fátima de Almeida, Marilene Fernandes |
author_role |
author |
author2 |
Benavides Tala, Julio Andre [UNESP] Belaz Silva, Laís Dário [UNESP] Castro Castro, Fernando Favian [UNESP] Ribeiro, Bruna Letícia Devidé [UNESP] Appolinário, Camila Michele [UNESP] Katz, Iana Suly Santos Scheffer, Karin Corrêa Silva, Sandriana Ramos Rosa, Adriana Ruckert Barone, Gisely Toledo Alves Martorelli, Luzia Fátima de Almeida, Marilene Fernandes |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidad Andrés Bello Universidad Antonio Narino Cauca Popayan Immunology Laboratory Pasteur Institute of São Paulo Coordenadoria de vigilância em saúde |
dc.contributor.author.fl_str_mv |
Megid, Jane [UNESP] Benavides Tala, Julio Andre [UNESP] Belaz Silva, Laís Dário [UNESP] Castro Castro, Fernando Favian [UNESP] Ribeiro, Bruna Letícia Devidé [UNESP] Appolinário, Camila Michele [UNESP] Katz, Iana Suly Santos Scheffer, Karin Corrêa Silva, Sandriana Ramos Rosa, Adriana Ruckert Barone, Gisely Toledo Alves Martorelli, Luzia Fátima de Almeida, Marilene Fernandes |
dc.subject.por.fl_str_mv |
antibodies rabies RFFIT serology vampire bats virus neutralizing antibodies |
topic |
antibodies rabies RFFIT serology vampire bats virus neutralizing antibodies |
description |
The control of vampire bat rabies (VBR) in Brazil is based on the culling of Desmodus rotundus and the surveillance of outbreaks caused by D. rotundus in cattle and humans in addition to vaccination of susceptible livestock. The detection of anti-rabies antibodies in vampire bats indicates exposure to the rabies virus, and several studies have reported an increase of these antibodies following experimental infection. However, the dynamics of anti-rabies antibodies in natural populations of D. rotundus remains poorly understood. In this study, we took advantage of recent outbreaks of VBR among livestock in the Sao Paulo region of Brazil to test whether seroprevalence in D. rotundus reflects the incidence of rabies in nearby livestock populations. Sixty-four D. rotundus were captured during and after outbreaks from roost located in municipalities belonging to three regions with different incidences of rabies in herbivores. Sixteen seropositive bats were then kept in captivity for up to 120 days, and their antibodies and virus levels were quantified at different time points using the rapid fluorescent focus inhibition test (RFFIT). Antibody titers were associated with the occurrence of ongoing outbreak, with a higher proportion of bats showing titer >0.5 IU/ml in the region with a recent outbreak. However, low titers were still detected in bats from regions reporting the last outbreak of rabies at least 3 years prior to sampling. This study suggests that serological surveillance of rabies in vampire bats can be used as a tool to evaluate risk of outbreaks in at risk populations of cattle and human. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09-29 2022-04-29T08:46:00Z 2022-04-29T08:46:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fvets.2021.681423 Frontiers in Veterinary Science, v. 8. 2297-1769 http://hdl.handle.net/11449/231532 10.3389/fvets.2021.681423 2-s2.0-85117140162 |
url |
http://dx.doi.org/10.3389/fvets.2021.681423 http://hdl.handle.net/11449/231532 |
identifier_str_mv |
Frontiers in Veterinary Science, v. 8. 2297-1769 10.3389/fvets.2021.681423 2-s2.0-85117140162 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129020800270336 |