Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus

Detalhes bibliográficos
Autor(a) principal: Megid, Jane [UNESP]
Data de Publicação: 2021
Outros Autores: Benavides Tala, Julio Andre [UNESP], Belaz Silva, Laís Dário [UNESP], Castro Castro, Fernando Favian [UNESP], Ribeiro, Bruna Letícia Devidé [UNESP], Appolinário, Camila Michele [UNESP], Katz, Iana Suly Santos, Scheffer, Karin Corrêa, Silva, Sandriana Ramos, Rosa, Adriana Ruckert, Barone, Gisely Toledo, Alves Martorelli, Luzia Fátima, de Almeida, Marilene Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3389/fvets.2021.681423
http://hdl.handle.net/11449/231532
Resumo: The control of vampire bat rabies (VBR) in Brazil is based on the culling of Desmodus rotundus and the surveillance of outbreaks caused by D. rotundus in cattle and humans in addition to vaccination of susceptible livestock. The detection of anti-rabies antibodies in vampire bats indicates exposure to the rabies virus, and several studies have reported an increase of these antibodies following experimental infection. However, the dynamics of anti-rabies antibodies in natural populations of D. rotundus remains poorly understood. In this study, we took advantage of recent outbreaks of VBR among livestock in the Sao Paulo region of Brazil to test whether seroprevalence in D. rotundus reflects the incidence of rabies in nearby livestock populations. Sixty-four D. rotundus were captured during and after outbreaks from roost located in municipalities belonging to three regions with different incidences of rabies in herbivores. Sixteen seropositive bats were then kept in captivity for up to 120 days, and their antibodies and virus levels were quantified at different time points using the rapid fluorescent focus inhibition test (RFFIT). Antibody titers were associated with the occurrence of ongoing outbreak, with a higher proportion of bats showing titer >0.5 IU/ml in the region with a recent outbreak. However, low titers were still detected in bats from regions reporting the last outbreak of rabies at least 3 years prior to sampling. This study suggests that serological surveillance of rabies in vampire bats can be used as a tool to evaluate risk of outbreaks in at risk populations of cattle and human.
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spelling Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundusantibodiesrabiesRFFITserologyvampire batsvirus neutralizing antibodiesThe control of vampire bat rabies (VBR) in Brazil is based on the culling of Desmodus rotundus and the surveillance of outbreaks caused by D. rotundus in cattle and humans in addition to vaccination of susceptible livestock. The detection of anti-rabies antibodies in vampire bats indicates exposure to the rabies virus, and several studies have reported an increase of these antibodies following experimental infection. However, the dynamics of anti-rabies antibodies in natural populations of D. rotundus remains poorly understood. In this study, we took advantage of recent outbreaks of VBR among livestock in the Sao Paulo region of Brazil to test whether seroprevalence in D. rotundus reflects the incidence of rabies in nearby livestock populations. Sixty-four D. rotundus were captured during and after outbreaks from roost located in municipalities belonging to three regions with different incidences of rabies in herbivores. Sixteen seropositive bats were then kept in captivity for up to 120 days, and their antibodies and virus levels were quantified at different time points using the rapid fluorescent focus inhibition test (RFFIT). Antibody titers were associated with the occurrence of ongoing outbreak, with a higher proportion of bats showing titer >0.5 IU/ml in the region with a recent outbreak. However, low titers were still detected in bats from regions reporting the last outbreak of rabies at least 3 years prior to sampling. This study suggests that serological surveillance of rabies in vampire bats can be used as a tool to evaluate risk of outbreaks in at risk populations of cattle and human.School of Veterinary Medicine and Animal Science São Paulo State University (Unesp)Centro de Investigación para la sustestabilidad Facultad de Ciencias de la vida Universidad Andrés BelloAnimal Health Department Universidad Antonio Narino Cauca PopayanDiagnostics Sector Immunology Laboratory Pasteur Institute of São PauloCentro de Controle de Zoonoses Coordenadoria de vigilância em saúdeSchool of Veterinary Medicine and Animal Science São Paulo State University (Unesp)Universidade Estadual Paulista (UNESP)Universidad Andrés BelloUniversidad Antonio Narino Cauca PopayanImmunology Laboratory Pasteur Institute of São PauloCoordenadoria de vigilância em saúdeMegid, Jane [UNESP]Benavides Tala, Julio Andre [UNESP]Belaz Silva, Laís Dário [UNESP]Castro Castro, Fernando Favian [UNESP]Ribeiro, Bruna Letícia Devidé [UNESP]Appolinário, Camila Michele [UNESP]Katz, Iana Suly SantosScheffer, Karin CorrêaSilva, Sandriana RamosRosa, Adriana RuckertBarone, Gisely ToledoAlves Martorelli, Luzia Fátimade Almeida, Marilene Fernandes2022-04-29T08:46:00Z2022-04-29T08:46:00Z2021-09-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fvets.2021.681423Frontiers in Veterinary Science, v. 8.2297-1769http://hdl.handle.net/11449/23153210.3389/fvets.2021.6814232-s2.0-85117140162Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Veterinary Scienceinfo:eu-repo/semantics/openAccess2022-04-29T08:46:01Zoai:repositorio.unesp.br:11449/231532Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:06:35.566277Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
title Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
spellingShingle Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
Megid, Jane [UNESP]
antibodies
rabies
RFFIT
serology
vampire bats
virus neutralizing antibodies
title_short Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
title_full Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
title_fullStr Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
title_full_unstemmed Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
title_sort Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus
author Megid, Jane [UNESP]
author_facet Megid, Jane [UNESP]
Benavides Tala, Julio Andre [UNESP]
Belaz Silva, Laís Dário [UNESP]
Castro Castro, Fernando Favian [UNESP]
Ribeiro, Bruna Letícia Devidé [UNESP]
Appolinário, Camila Michele [UNESP]
Katz, Iana Suly Santos
Scheffer, Karin Corrêa
Silva, Sandriana Ramos
Rosa, Adriana Ruckert
Barone, Gisely Toledo
Alves Martorelli, Luzia Fátima
de Almeida, Marilene Fernandes
author_role author
author2 Benavides Tala, Julio Andre [UNESP]
Belaz Silva, Laís Dário [UNESP]
Castro Castro, Fernando Favian [UNESP]
Ribeiro, Bruna Letícia Devidé [UNESP]
Appolinário, Camila Michele [UNESP]
Katz, Iana Suly Santos
Scheffer, Karin Corrêa
Silva, Sandriana Ramos
Rosa, Adriana Ruckert
Barone, Gisely Toledo
Alves Martorelli, Luzia Fátima
de Almeida, Marilene Fernandes
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidad Andrés Bello
Universidad Antonio Narino Cauca Popayan
Immunology Laboratory Pasteur Institute of São Paulo
Coordenadoria de vigilância em saúde
dc.contributor.author.fl_str_mv Megid, Jane [UNESP]
Benavides Tala, Julio Andre [UNESP]
Belaz Silva, Laís Dário [UNESP]
Castro Castro, Fernando Favian [UNESP]
Ribeiro, Bruna Letícia Devidé [UNESP]
Appolinário, Camila Michele [UNESP]
Katz, Iana Suly Santos
Scheffer, Karin Corrêa
Silva, Sandriana Ramos
Rosa, Adriana Ruckert
Barone, Gisely Toledo
Alves Martorelli, Luzia Fátima
de Almeida, Marilene Fernandes
dc.subject.por.fl_str_mv antibodies
rabies
RFFIT
serology
vampire bats
virus neutralizing antibodies
topic antibodies
rabies
RFFIT
serology
vampire bats
virus neutralizing antibodies
description The control of vampire bat rabies (VBR) in Brazil is based on the culling of Desmodus rotundus and the surveillance of outbreaks caused by D. rotundus in cattle and humans in addition to vaccination of susceptible livestock. The detection of anti-rabies antibodies in vampire bats indicates exposure to the rabies virus, and several studies have reported an increase of these antibodies following experimental infection. However, the dynamics of anti-rabies antibodies in natural populations of D. rotundus remains poorly understood. In this study, we took advantage of recent outbreaks of VBR among livestock in the Sao Paulo region of Brazil to test whether seroprevalence in D. rotundus reflects the incidence of rabies in nearby livestock populations. Sixty-four D. rotundus were captured during and after outbreaks from roost located in municipalities belonging to three regions with different incidences of rabies in herbivores. Sixteen seropositive bats were then kept in captivity for up to 120 days, and their antibodies and virus levels were quantified at different time points using the rapid fluorescent focus inhibition test (RFFIT). Antibody titers were associated with the occurrence of ongoing outbreak, with a higher proportion of bats showing titer >0.5 IU/ml in the region with a recent outbreak. However, low titers were still detected in bats from regions reporting the last outbreak of rabies at least 3 years prior to sampling. This study suggests that serological surveillance of rabies in vampire bats can be used as a tool to evaluate risk of outbreaks in at risk populations of cattle and human.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-29
2022-04-29T08:46:00Z
2022-04-29T08:46:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3389/fvets.2021.681423
Frontiers in Veterinary Science, v. 8.
2297-1769
http://hdl.handle.net/11449/231532
10.3389/fvets.2021.681423
2-s2.0-85117140162
url http://dx.doi.org/10.3389/fvets.2021.681423
http://hdl.handle.net/11449/231532
identifier_str_mv Frontiers in Veterinary Science, v. 8.
2297-1769
10.3389/fvets.2021.681423
2-s2.0-85117140162
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Frontiers in Veterinary Science
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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