Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UNOESTE |
Texto Completo: | http://bdtd.unoeste.br:8080/jspui/handle/jspui/1341 |
Resumo: | Herbicides are agents made up of a wide variety of chemical or biological compounds designed to eliminate, fight, repel or control insects. Ingestion, respiration, or dermal contact with pesticides of the phenoxyacetic acid class, such as dichlorophenoxyacetic acid (2,4-D), can cause loss of appetite, nausea, vomiting, muscle fasciculation, and even cancer. 2,4-D-associated neurotoxicity is controversial. The aim of this study was to evaluate the possible neurotoxic effect of chronic oral and inhalation exposure of the herbicide dichlorophenoxyacetic acid (2,4-D). For the experiments, 80 male adult rats (200-250g) were divided into eight groups (n = 10): Group 1: nebulization with sodium chloride solution (NaCl); Group 2: food nebulized with sodium chloride solution (NaCl); Group 3: herbicide nebulization with 3.71 x 10-3 grams of active ingredient per hectare (g.i.a / ha); Group 4: nebulized feed with herbicide at a concentration of 3.71 x 10-3 g.i.a / ha; Group 5: 6.19 x 10-3 g.i.a / ha herbicide nebulization; Group 6: herbicide nebulized feed at a concentration of 6.19 x 10-3 g.i.a / ha; Group 7: 9.28 x 10-3 g.i.a / ha herbicide nebulization; Group 8: Nebulized herbicide feed at a concentration of 9.28 x 10-3 g.i.a / ha. Daily nebulization for 15 minutes for 6 months. For behavioral evaluation the behavioral tests were: Open Field Test and High Cross Maze, whose objective will be the observation of the general health, neurological reflexes, sensory skills and motor function of the animals used. Brain was collected for histological and immunohistochemical analysis. Results: The administration of 2,4-D for six months led to a deficit in the neurobehavioral tests that evaluated locomotion and anxiety level of animals, regardless of the exposure route (oral or inhaled). There was individual necrosis of neurons and a decrease in the thickness of the cerebral cortex associated with increased expression of the BAX antibody (a pro-apoptotic marker). Conclusion: This study demonstrated that 2,4-D leads to neurodegeneration of the central nervous system by deregulation of pro-apoptotic proteins. |
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Nai, Gisele Alborghettihttp://lattes.cnpq.br/6057606215850166Teixeira, Giovana Rampazzohttp://lattes.cnpq.br/2315704053720238Basso, Karina Mariahttp://lattes.cnpq.br/8826304128453691Santarém, Cecília Laposyhttp://lattes.cnpq.br/6243360005165063Nogueira, Rosa Maria Barillihttp://lattes.cnpq.br/755664774676861506676734826http://lattes.cnpq.br/4219632019326044Ueda, Rose Meire Riçato2021-07-02T13:28:59Z2020-11-16Ueda, Rose Meire Riçato. Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos. 2020. 82f. Tese (Doutorado em Fisiopatologia e Saúde Animal) - Universidade do Oeste Paulista, Presidente Prudente, 2020.http://bdtd.unoeste.br:8080/jspui/handle/jspui/1341Herbicides are agents made up of a wide variety of chemical or biological compounds designed to eliminate, fight, repel or control insects. Ingestion, respiration, or dermal contact with pesticides of the phenoxyacetic acid class, such as dichlorophenoxyacetic acid (2,4-D), can cause loss of appetite, nausea, vomiting, muscle fasciculation, and even cancer. 2,4-D-associated neurotoxicity is controversial. The aim of this study was to evaluate the possible neurotoxic effect of chronic oral and inhalation exposure of the herbicide dichlorophenoxyacetic acid (2,4-D). For the experiments, 80 male adult rats (200-250g) were divided into eight groups (n = 10): Group 1: nebulization with sodium chloride solution (NaCl); Group 2: food nebulized with sodium chloride solution (NaCl); Group 3: herbicide nebulization with 3.71 x 10-3 grams of active ingredient per hectare (g.i.a / ha); Group 4: nebulized feed with herbicide at a concentration of 3.71 x 10-3 g.i.a / ha; Group 5: 6.19 x 10-3 g.i.a / ha herbicide nebulization; Group 6: herbicide nebulized feed at a concentration of 6.19 x 10-3 g.i.a / ha; Group 7: 9.28 x 10-3 g.i.a / ha herbicide nebulization; Group 8: Nebulized herbicide feed at a concentration of 9.28 x 10-3 g.i.a / ha. Daily nebulization for 15 minutes for 6 months. For behavioral evaluation the behavioral tests were: Open Field Test and High Cross Maze, whose objective will be the observation of the general health, neurological reflexes, sensory skills and motor function of the animals used. Brain was collected for histological and immunohistochemical analysis. Results: The administration of 2,4-D for six months led to a deficit in the neurobehavioral tests that evaluated locomotion and anxiety level of animals, regardless of the exposure route (oral or inhaled). There was individual necrosis of neurons and a decrease in the thickness of the cerebral cortex associated with increased expression of the BAX antibody (a pro-apoptotic marker). Conclusion: This study demonstrated that 2,4-D leads to neurodegeneration of the central nervous system by deregulation of pro-apoptotic proteins.Os herbicidas são agentes constituídos por uma grande variedade de compostos químicos ou biológicos, desenvolvidos para eliminar, combater, repelir ou controlar insetos. A ingestão, respiração ou contato dérmico com agrotóxicos da classe dos ácidos fenoxiacéticos, como o ácido diclorofenóxiacético (2,4-D), pode causar perda de apetite, enjôo, vômito, fasciculação muscular e até mesmo câncer. A neurotoxicidade associada ao 2,4-D é controversa. O objetivo deste estudo foi avalair o possível efeito neurotóxico da exposição crônica por via oral e inalatória do herbicida ácido diclorofenóxiacético (2,4-D). Para a realização dos experimentos, foram utilizados 80 ratos adultos, machos (200-250g) divididos em oito grupos (n=10): Grupo 1: nebulização com solução de cloreto de sódio (NaCl); Grupo 2: ração nebulizada com solução de cloreto de sódio (NaCl); Grupo 3: nebulização com herbicida com 3,71 x 10-3 gramas de ingrediente ativo por hectare (g.i.a/ha); Grupo 4: ração nebulizada com herbicida na concentração de 3,71 x 10-3 g.i.a/ha; Grupo 5: nebulização com herbicida com 6,19 x 10-3 g.i.a/ha; Grupo 6: ração nebulizada com herbicida na concentração de 6,19 x 10-3 g.i.a/ha; Grupo 7: nebulização com herbicida com 9,28 x 10-3 g.i.a/ha; Grupo 8: ração nebulizada com herbicida na concentração de 9,28 x 10-3 g.i.a/ha. Nebulização diária por 15 minutos durante 6 meses. Para avaliação comportamental os testes comportamentais utilizados foram: Teste de campo aberto e Labirinto em Cruz Elevado, cujo objetivo será a observação do estado geral de saúde, dos reflexos neurológicos, das habilidades sensoriais e da função motora dos animais utilizados. Animais de todos os grupos foram eutanasiados 6 meses após o início do experimento. Foi coletado cérebro para análise histológica e imunoistoquímica. A administração do 2,4-D por seis meses acarretou em déficit aos testes neurocomportamentais que avaliaram locomoção e nível de ansiedade, independente da via de exposição (oral ou inalatória). Houve necrose individual de neurônios e diminuição da espessura do córtex cerebral associada a aumento da expressão do anticorpo BAX (um marcador pró-apoptótico). Este estudo demonstrou que o 2,4-D leva a neurodegeneração do sistema nervoso central por desregulação de proteínas pró-apoptóticas.Submitted by Michele Mologni (mologni@unoeste.br) on 2021-07-02T13:28:59Z No. of bitstreams: 1 Rose Meire Riçato Ueda.pdf: 1228287 bytes, checksum: 1164965b4c6d4932e4721c4dfb296f3e (MD5)Made available in DSpace on 2021-07-02T13:28:59Z (GMT). No. of bitstreams: 1 Rose Meire Riçato Ueda.pdf: 1228287 bytes, checksum: 1164965b4c6d4932e4721c4dfb296f3e (MD5) Previous issue date: 2020-11-16application/pdfhttp://bdtd.unoeste.br:8080/jspui/retrieve/4260/Rose%20Meire%20Ri%c3%a7ato%20Ueda.pdf.jpgporUniversidade do Oeste PaulistaDoutorado em Fisiopatologia e Saúde AnimalUNOESTEBrasilDoutorado em Fisiopatologia e Saúde Animalherbicidas, cérebro, modelo experimental, exposição ambiental, testes neuropsicológicos.herbicides, brain, experimental model, environmental exposure, neuropsychological tests.CIENCIAS AGRARIAS::MEDICINA VETERINARIANeurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratosNeurotoxicity associated with chronic inhalation and oral exposure to dichlorophenxiaetic acid (2,4-D) in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis56116417490182658795005006005611641749018265879453670264235017319info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UNOESTEinstname:Universidade do Oeste Paulista (UNOESTE)instacron:UNOESTETHUMBNAILRose Meire Riçato Ueda.pdf.jpgRose Meire Riçato Ueda.pdf.jpgimage/jpeg3696http://bdtd.unoeste.br:8080/tede/bitstream/jspui/1341/3/Rose+Meire+Ri%C3%A7ato+Ueda.pdf.jpg51ed51cb7b9ae4bf5e7ae1bf0423acbaMD53ORIGINALRose Meire Riçato Ueda.pdfRose Meire Riçato Ueda.pdfapplication/pdf1228287http://bdtd.unoeste.br:8080/tede/bitstream/jspui/1341/2/Rose+Meire+Ri%C3%A7ato+Ueda.pdf1164965b4c6d4932e4721c4dfb296f3eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82067http://bdtd.unoeste.br:8080/tede/bitstream/jspui/1341/1/license.txt47745281809acb27fb322a97f2d9cb88MD51jspui/13412021-07-03 01:01:12.052oai:bdtd.unoeste.br:jspui/1341TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTyBFWENMVVNJVkEKCkNvbSBhIGFwcmVzZW50YcOnw6NvIGRlc3RhIGxpY2Vuw6dhLCB2b2PDqiAobm9tZSBkbyBhdXRvcikgY29uY2VkZSDDoCBVbml2ZXJzaWRhZGUgZG8gT2VzdGUgUGF1bGlzdGEg4oCTIFVOT0VTVEUsIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSByZXByb2R1emlyLCAgdHJhZHV6aXIgKGNvbmZvcm1lIGRlZmluaWRvIGFiYWl4byksIGUvb3UgZGlzdHJpYnVpciBhIHN1YSB0ZXNlIG91IGRpc3NlcnRhw6fDo28gKGluY2x1aW5kbyBvIHJlc3VtbykgcG9yIHRvZG8gbyBtdW5kbyBubyBmb3JtYXRvIGltcHJlc3NvIGUgZWxldHLDtG5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mgw6F1ZGlvIG91IHbDrWRlby4KClZvY8OqIGNvbmNvcmRhIHF1ZSBhIFVOT0VTVEUgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250ZcO6ZG8sIHRyYW5zcG9yIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIHRhbWLDqW0gY29uY29yZGEgcXVlIGEgVU5PRVNURSBwb2RlIG1hbnRlciBtYWlzIGRlIHVtYSBjw7NwaWEgZGUgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyBwYXJhIGZpbnMgZGUgc2VndXJhbsOnYSwgYmFjay11cCBlIHByZXNlcnZhw6fDo28uCgpWb2PDqiBkZWNsYXJhIHF1ZSBhIHN1YSB0ZXNlIG91IGRpc3NlcnRhw6fDo28gw6kgb3JpZ2luYWwsIGUgcXVlIHZvY8OqIHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBWb2PDqiB0YW1iw6ltIGRlY2xhcmEgcXVlIG8gZGVww7NzaXRvIGRhIHN1YSB0ZXNlIG91IGRpc3NlcnRhw6fDo28gbsOjbyBpbmZyaW5nZSwgcXVlIHNlamEgZGUgc2V1IGNvbmhlY2ltZW50bywgZGlyZWl0b3MgYXV0b3JhaXMgZGUgbmluZ3XDqW0uCgpDYXNvIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyBjb250ZW5oYSBtYXRlcmlhbCBxdWUgdm9jw6ogbsOjbyBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2PDqiBkZWNsYXJhIHF1ZSBvYnRldmUgYSBwZXJtaXNzw6NvIGlycmVzdHJpdGEgZG8gZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIHBhcmEgY29uY2VkZXIgw6AgVU5PRVNURSBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7Dp2EsIGUgcXVlIGVzc2UgbWF0ZXJpYWwgZGUgcHJvcHJpZWRhZGUgZGUgdGVyY2Vpcm9zIGVzdMOhIGNsYXJhbWVudGUgaWRlbnRpZmljYWRvIGUgcmVjb25oZWNpZG8gbm8gdGV4dG8gb3Ugbm8gY29udGXDumRvIGRhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyBvcmEgZGVwb3NpdGFkYS4KCkNhc28gYSB0ZXNlIG91IGRpc3NlcnRhw6fDo28gb3JhIGRlcG9zaXRhZGEgdGVuaGEgc2lkbyByZXN1bHRhZG8gZGUgdW0gcGF0cm9jw61uaW8gb3UgYXBvaW8gZGUgdW1hIGFnw6puY2lhIGRlIGZvbWVudG8gb3Ugb3V0cm8gb3JnYW5pc21vLCBxdWUgbsOjbyBzZWphIGEgVU5PRVNURSwgdm9jw6ogZGVjbGFyYSBxdWUgcmVzcGVpdG91IHRvZG9zIGUgcXVhaXNxdWVyIGRpcmVpdG9zIGRlIHJldmlzw6NvLCBjb21vIHRhbWLDqW0sIGFzIGRlbWFpcyBvYnJpZ2HDp8O1ZXMgZXhpZ2lkYXMgcG9yIGNvbnRyYXRvIG91IGFjb3Jkby4KCkEgVU5PRVNURSBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lIChzKSBvdSBvKHMpIG5vbWUocykgZG8ocykgZGV0ZW50b3IgKGVzKSBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgZGEgdGVzZSBvdSBkaXNzZXJ0YcOnw6NvLCBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIGFsw6ltIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7Dp2EuCgpFIHBvciBzZXJlbSB2ZXJkYWRlaXJhcyBhcyBpbmZvcm1hw6fDtWVzIGFjaW1hIGNpdGFkYXMsIGNvbmNlZG8gYSBsaWNlbsOnYSBkZSBkaXN0cmlidWnDp8OjbyBuw6NvIGV4Y2x1c2l2YSBwYXJhIGEgVU5PRVNURS4KBiblioteca Digital de Teses e Dissertaçõeshttp://bdtd.unoeste.br:8080/jspui/PUBhttp://bdtd.unoeste.br:8080/oai/requestbdtd@unoeste.bropendoar:2021-07-03T04:01:12Biblioteca Digital de Teses e Dissertações da UNOESTE - Universidade do Oeste Paulista (UNOESTE)false |
dc.title.por.fl_str_mv |
Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos |
dc.title.alternative.eng.fl_str_mv |
Neurotoxicity associated with chronic inhalation and oral exposure to dichlorophenxiaetic acid (2,4-D) in rats |
title |
Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos |
spellingShingle |
Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos Ueda, Rose Meire Riçato herbicidas, cérebro, modelo experimental, exposição ambiental, testes neuropsicológicos. herbicides, brain, experimental model, environmental exposure, neuropsychological tests. CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos |
title_full |
Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos |
title_fullStr |
Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos |
title_full_unstemmed |
Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos |
title_sort |
Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos |
author |
Ueda, Rose Meire Riçato |
author_facet |
Ueda, Rose Meire Riçato |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Nai, Gisele Alborghetti |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6057606215850166 |
dc.contributor.referee1.fl_str_mv |
Teixeira, Giovana Rampazzo |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2315704053720238 |
dc.contributor.referee2.fl_str_mv |
Basso, Karina Maria |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/8826304128453691 |
dc.contributor.referee3.fl_str_mv |
Santarém, Cecília Laposy |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/6243360005165063 |
dc.contributor.referee4.fl_str_mv |
Nogueira, Rosa Maria Barilli |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/7556647746768615 |
dc.contributor.authorID.fl_str_mv |
06676734826 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4219632019326044 |
dc.contributor.author.fl_str_mv |
Ueda, Rose Meire Riçato |
contributor_str_mv |
Nai, Gisele Alborghetti Teixeira, Giovana Rampazzo Basso, Karina Maria Santarém, Cecília Laposy Nogueira, Rosa Maria Barilli |
dc.subject.por.fl_str_mv |
herbicidas, cérebro, modelo experimental, exposição ambiental, testes neuropsicológicos. |
topic |
herbicidas, cérebro, modelo experimental, exposição ambiental, testes neuropsicológicos. herbicides, brain, experimental model, environmental exposure, neuropsychological tests. CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.eng.fl_str_mv |
herbicides, brain, experimental model, environmental exposure, neuropsychological tests. |
dc.subject.cnpq.fl_str_mv |
CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
Herbicides are agents made up of a wide variety of chemical or biological compounds designed to eliminate, fight, repel or control insects. Ingestion, respiration, or dermal contact with pesticides of the phenoxyacetic acid class, such as dichlorophenoxyacetic acid (2,4-D), can cause loss of appetite, nausea, vomiting, muscle fasciculation, and even cancer. 2,4-D-associated neurotoxicity is controversial. The aim of this study was to evaluate the possible neurotoxic effect of chronic oral and inhalation exposure of the herbicide dichlorophenoxyacetic acid (2,4-D). For the experiments, 80 male adult rats (200-250g) were divided into eight groups (n = 10): Group 1: nebulization with sodium chloride solution (NaCl); Group 2: food nebulized with sodium chloride solution (NaCl); Group 3: herbicide nebulization with 3.71 x 10-3 grams of active ingredient per hectare (g.i.a / ha); Group 4: nebulized feed with herbicide at a concentration of 3.71 x 10-3 g.i.a / ha; Group 5: 6.19 x 10-3 g.i.a / ha herbicide nebulization; Group 6: herbicide nebulized feed at a concentration of 6.19 x 10-3 g.i.a / ha; Group 7: 9.28 x 10-3 g.i.a / ha herbicide nebulization; Group 8: Nebulized herbicide feed at a concentration of 9.28 x 10-3 g.i.a / ha. Daily nebulization for 15 minutes for 6 months. For behavioral evaluation the behavioral tests were: Open Field Test and High Cross Maze, whose objective will be the observation of the general health, neurological reflexes, sensory skills and motor function of the animals used. Brain was collected for histological and immunohistochemical analysis. Results: The administration of 2,4-D for six months led to a deficit in the neurobehavioral tests that evaluated locomotion and anxiety level of animals, regardless of the exposure route (oral or inhaled). There was individual necrosis of neurons and a decrease in the thickness of the cerebral cortex associated with increased expression of the BAX antibody (a pro-apoptotic marker). Conclusion: This study demonstrated that 2,4-D leads to neurodegeneration of the central nervous system by deregulation of pro-apoptotic proteins. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-11-16 |
dc.date.accessioned.fl_str_mv |
2021-07-02T13:28:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Ueda, Rose Meire Riçato. Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos. 2020. 82f. Tese (Doutorado em Fisiopatologia e Saúde Animal) - Universidade do Oeste Paulista, Presidente Prudente, 2020. |
dc.identifier.uri.fl_str_mv |
http://bdtd.unoeste.br:8080/jspui/handle/jspui/1341 |
identifier_str_mv |
Ueda, Rose Meire Riçato. Neurotoxicidade associada à exposição crônica via inalatória e via oral ao ácido diclorofenóxiacético (2,4-D) em ratos. 2020. 82f. Tese (Doutorado em Fisiopatologia e Saúde Animal) - Universidade do Oeste Paulista, Presidente Prudente, 2020. |
url |
http://bdtd.unoeste.br:8080/jspui/handle/jspui/1341 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
5611641749018265879 |
dc.relation.confidence.fl_str_mv |
500 500 600 |
dc.relation.department.fl_str_mv |
5611641749018265879 |
dc.relation.cnpq.fl_str_mv |
453670264235017319 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade do Oeste Paulista |
dc.publisher.program.fl_str_mv |
Doutorado em Fisiopatologia e Saúde Animal |
dc.publisher.initials.fl_str_mv |
UNOESTE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Doutorado em Fisiopatologia e Saúde Animal |
publisher.none.fl_str_mv |
Universidade do Oeste Paulista |
dc.source.none.fl_str_mv |
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Universidade do Oeste Paulista (UNOESTE) |
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UNOESTE |
institution |
UNOESTE |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UNOESTE |
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Biblioteca Digital de Teses e Dissertações da UNOESTE |
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bitstream.checksum.fl_str_mv |
51ed51cb7b9ae4bf5e7ae1bf0423acba 1164965b4c6d4932e4721c4dfb296f3e 47745281809acb27fb322a97f2d9cb88 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações da UNOESTE - Universidade do Oeste Paulista (UNOESTE) |
repository.mail.fl_str_mv |
bdtd@unoeste.br |
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1766605151348457472 |