Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/11695 |
Resumo: | The described neurological symptoms associated with pesticide exposure include memory and concentration problems. Most experimental studies of the association between dichlorophenoxyacetic acid (2,4-D) and neurotoxicity have focused on brain development, and few have been conducted in adult animals. The aim of this study was to assess whether chronic oral or inhalation exposure to 2,4-D affects object recognition memory in adult rats. Forty albino Wistar rats were used and distributed into 4 groups (n = 10): I: animals nebulized with distilled water; O: animals receiving feed treated with nebulized distilled water; DI: animals nebulized with 9.28 x 10-3 grams of active ingredient per hectare (g.a.i./ha) of 2,4-D; and DO: animals receiving feed treated with 9.28 x 10-3 g.a.i./ha of nebulized 2,4-D. The animals were exposed for 6 months. To assess recognition memory, the object recognition test was used. Compared to control animals, animals exposed to 2,4-D spent less time exploring objects (p <0.05) and obtained an object recognition index score of -1. Route of exposure to 2,4-D had an effect only on the time spent exploring objects, which was shorter in animals exposed orally. Chronic exposure to a high concentration of 2,4-D alters the ability of adult animals to recognize objects. |
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Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult ratsAlteración de la memoria de reconocimiento de objetos tras la exposición crónica al ácido diclorofenoxiacético (2,4-D) en ratas adultasAlteração da memória de reconhecimento de objetos após exposição crônica ao ácido diclorofenoxiacético (2,4-D) em ratos adultosAgroquímicosHerbicidasTrastornos de la memoriaPruebas neuropsicológicasCebado de repetición.AgrochemicalsHerbicidesMemory disordersNeuropsychological testsRepetition priming.AgroquímicosHerbicidasDistúrbios de memóriaTestes neuropsicológicosPriming de repetição.The described neurological symptoms associated with pesticide exposure include memory and concentration problems. Most experimental studies of the association between dichlorophenoxyacetic acid (2,4-D) and neurotoxicity have focused on brain development, and few have been conducted in adult animals. The aim of this study was to assess whether chronic oral or inhalation exposure to 2,4-D affects object recognition memory in adult rats. Forty albino Wistar rats were used and distributed into 4 groups (n = 10): I: animals nebulized with distilled water; O: animals receiving feed treated with nebulized distilled water; DI: animals nebulized with 9.28 x 10-3 grams of active ingredient per hectare (g.a.i./ha) of 2,4-D; and DO: animals receiving feed treated with 9.28 x 10-3 g.a.i./ha of nebulized 2,4-D. The animals were exposed for 6 months. To assess recognition memory, the object recognition test was used. Compared to control animals, animals exposed to 2,4-D spent less time exploring objects (p <0.05) and obtained an object recognition index score of -1. Route of exposure to 2,4-D had an effect only on the time spent exploring objects, which was shorter in animals exposed orally. Chronic exposure to a high concentration of 2,4-D alters the ability of adult animals to recognize objects.Los síntomas neurológicos descritos asociados con la exposición a pesticidas incluyen problemas de memoria y concentración. La mayoría de los estudios experimentales de la asociación entre ácido diclorofenoxiacético (2,4-D) y neurotoxicidad se han centrado en el desarrollo del cerebro y pocos se han realizado en animales adultos. El objetivo de este estudio fue evaluar si la exposición crónica por vía oral o por inhalación al 2,4-D afecta la memoria de reconocimiento de objetos en ratas adultas. Se utilizaron cuarenta ratas albinas Wistar y se distribuyeron en 4 grupos (n = 10): I: animales nebulizados con agua destilada; O: animales que reciben alimento tratado con agua destilada nebulizada; DI: animales nebulizados con 9,28 x 10-3 gramos de ingrediente activo por hectárea (g.i.a./ha) de 2,4-D; y DO: animales que reciben alimento tratado con 9.28 x 10-3 g.i.a./ha de 2,4-D nebulizado. Los animales estuvieron expuestos durante 6 meses. Para evaluar la memoria de reconocimiento se utilizó la prueba de reconocimiento de objetos. En comparación con los animales de control, los animales expuestos a 2,4-D pasaron menos tiempo explorando objetos (p <0,05) y obtuvieron una puntuación de índice de reconocimiento de objetos de -1. La ruta de exposición al 2,4-D tuvo efecto solo en el tiempo dedicado a explorar objetos, que fue más corto en los animales expuestos por vía oral. La exposición crónica a una alta concentración de 2,4-D altera la capacidad de los animales adultos para reconocer objetos.Os sintomas neurológicos descritos associados à exposição a pesticidas incluem problemas de memória e concentração. A maioria dos estudos experimentais da associação entre ácido diclorofenoxiacético (2,4-D) e neurotoxicidade enfocou o desenvolvimento do cérebro, e poucos foram conduzidos em animais adultos. O objetivo deste estudo foi avaliar se a exposição oral crônica ou inalatória ao 2,4-D afeta a memória de reconhecimento de objetos em ratos adultos. Foram utilizados 40 ratos albinos Wistar, distribuídos em 4 grupos (n = 10): I: animais nebulizados com água destilada; O: animais recebendo ração tratada com água destilada nebulizada; DI: animais nebulizados com 9,28 x 10-3 gramas de ingrediente ativo por hectare (g.a.i./ha) de 2,4-D; e DO: animais que receberam ração tratada com 9,28 x 10-3 g.a.i./ha de 2,4-D nebulizado. Os animais ficaram expostos por 6 meses. Para avaliar a memória de reconhecimento, foi utilizado o teste de reconhecimento de objetos. Em comparação com os animais controle, os animais expostos ao 2,4-D gastaram menos tempo explorando objetos (p <0,05) e obtiveram um índice de reconhecimento de objeto de -1. A rota de exposição ao 2,4-D afetou apenas o tempo despendido na exploração de objetos, sendo menor nos animais expostos por via oral. A exposição crônica a uma alta concentração de 2,4-D altera a capacidade dos animais adultos de reconhecer objetos.Research, Society and Development2021-01-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1169510.33448/rsd-v10i1.11695Research, Society and Development; Vol. 10 No. 1; e23310111695Research, Society and Development; Vol. 10 Núm. 1; e23310111695Research, Society and Development; v. 10 n. 1; e233101116952525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/11695/10448Copyright (c) 2021 Rose Meire Riçato Ueda; Verena Miranda de Souza; Letícia Rocha Magalhães; Rogério Giuffrida; Gisele Alborghetti Naihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessUeda, Rose Meire Riçato Souza, Verena Miranda deMagalhães, Letícia Rocha Giuffrida, Rogério Nai, Gisele Alborghetti 2021-02-20T21:19:23Zoai:ojs.pkp.sfu.ca:article/11695Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:33:26.824307Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats Alteración de la memoria de reconocimiento de objetos tras la exposición crónica al ácido diclorofenoxiacético (2,4-D) en ratas adultas Alteração da memória de reconhecimento de objetos após exposição crônica ao ácido diclorofenoxiacético (2,4-D) em ratos adultos |
| title |
Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats |
| spellingShingle |
Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats Ueda, Rose Meire Riçato Agroquímicos Herbicidas Trastornos de la memoria Pruebas neuropsicológicas Cebado de repetición. Agrochemicals Herbicides Memory disorders Neuropsychological tests Repetition priming. Agroquímicos Herbicidas Distúrbios de memória Testes neuropsicológicos Priming de repetição. |
| title_short |
Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats |
| title_full |
Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats |
| title_fullStr |
Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats |
| title_full_unstemmed |
Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats |
| title_sort |
Alteration of object recognition memory after chronic exposure to dichlorophenoxyacetic acid (2,4-D) in adult rats |
| author |
Ueda, Rose Meire Riçato |
| author_facet |
Ueda, Rose Meire Riçato Souza, Verena Miranda de Magalhães, Letícia Rocha Giuffrida, Rogério Nai, Gisele Alborghetti |
| author_role |
author |
| author2 |
Souza, Verena Miranda de Magalhães, Letícia Rocha Giuffrida, Rogério Nai, Gisele Alborghetti |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Ueda, Rose Meire Riçato Souza, Verena Miranda de Magalhães, Letícia Rocha Giuffrida, Rogério Nai, Gisele Alborghetti |
| dc.subject.por.fl_str_mv |
Agroquímicos Herbicidas Trastornos de la memoria Pruebas neuropsicológicas Cebado de repetición. Agrochemicals Herbicides Memory disorders Neuropsychological tests Repetition priming. Agroquímicos Herbicidas Distúrbios de memória Testes neuropsicológicos Priming de repetição. |
| topic |
Agroquímicos Herbicidas Trastornos de la memoria Pruebas neuropsicológicas Cebado de repetición. Agrochemicals Herbicides Memory disorders Neuropsychological tests Repetition priming. Agroquímicos Herbicidas Distúrbios de memória Testes neuropsicológicos Priming de repetição. |
| description |
The described neurological symptoms associated with pesticide exposure include memory and concentration problems. Most experimental studies of the association between dichlorophenoxyacetic acid (2,4-D) and neurotoxicity have focused on brain development, and few have been conducted in adult animals. The aim of this study was to assess whether chronic oral or inhalation exposure to 2,4-D affects object recognition memory in adult rats. Forty albino Wistar rats were used and distributed into 4 groups (n = 10): I: animals nebulized with distilled water; O: animals receiving feed treated with nebulized distilled water; DI: animals nebulized with 9.28 x 10-3 grams of active ingredient per hectare (g.a.i./ha) of 2,4-D; and DO: animals receiving feed treated with 9.28 x 10-3 g.a.i./ha of nebulized 2,4-D. The animals were exposed for 6 months. To assess recognition memory, the object recognition test was used. Compared to control animals, animals exposed to 2,4-D spent less time exploring objects (p <0.05) and obtained an object recognition index score of -1. Route of exposure to 2,4-D had an effect only on the time spent exploring objects, which was shorter in animals exposed orally. Chronic exposure to a high concentration of 2,4-D alters the ability of adult animals to recognize objects. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-01-09 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/11695 10.33448/rsd-v10i1.11695 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/11695 |
| identifier_str_mv |
10.33448/rsd-v10i1.11695 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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https://rsdjournal.org/index.php/rsd/article/view/11695/10448 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 10 No. 1; e23310111695 Research, Society and Development; Vol. 10 Núm. 1; e23310111695 Research, Society and Development; v. 10 n. 1; e23310111695 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052668090253312 |