Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas

• Autor(a) principal: SILVA, Welma Emidio da
• Data de Publicação: 2012
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRPE
• Texto Completo: http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4683
• topic: Metronidazol; Prenhez; Desenvolvimento placentário; Desenvolvimento fetal; Pregnancy; Placental development; Fetal development; CIENCIAS AGRARIAS::MEDICINA VETERINARIA

Several authors have reported that metronidazole crosses the placental barrier and enters the fetal circulation and is still excreted in breast milk. Thus, not recommend the use of this drug in pregnant women and also the breastfeeding suspension for 12-24 hours after administration. However, some investigators report lack of evidence that the use of metronidazole is associated with increased risk teratogenic when administered during pregnancy is therefore unnecessary waiting for the termination of pregnancy for treatment with this drug. Thus, this study aimed to analyze the effect of administration of metronidazole during pregnancy on placental and fetal development of albino rats. 30 albino rats were used, which were divided into two groups. GROUP I - pregnant rats treated with placebo and GRUPOII - pregnant rats treated with metronidazole. The metronidazole was administered daily by gavage at a dose of 130 mg / kg for 7, 14 and 21 days of gestation. The results showed that the treated group a significant reduction in the number of deployment sites, the total area of the placental disc and the constituents of the layers of the labyrinth and trofospôngio. The histochemical analysis revealed no significant changes in the content of collagen and elastic fibers and reticular. The test showed TUNEL apoptotic activity at the site of implantation and placental development 14 days regardless of treatment. We did not observe any evidence of malformation in the head, trunk and limbs of neonates. However, a significant reduction in weight and number of neonates in the group treated with metronidazole compared to control. Thus, we conclude that metronidazole in pregnant rats administered orally at a dosage of 130 mg / kg, in two thirds of early pregnancy interferes with the interaction blastocyst endometrium, in placental and fetal development, suggesting that this drug should be avoided in the early stages of pregnancy.