Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas

Detalhes bibliográficos
Autor(a) principal: SILVA, Welma Emidio da
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRPE
Texto Completo: http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4683
Resumo: Several authors have reported that metronidazole crosses the placental barrier and enters the fetal circulation and is still excreted in breast milk. Thus, not recommend the use of this drug in pregnant women and also the breastfeeding suspension for 12-24 hours after administration. However, some investigators report lack of evidence that the use of metronidazole is associated with increased risk teratogenic when administered during pregnancy is therefore unnecessary waiting for the termination of pregnancy for treatment with this drug. Thus, this study aimed to analyze the effect of administration of metronidazole during pregnancy on placental and fetal development of albino rats. 30 albino rats were used, which were divided into two groups. GROUP I - pregnant rats treated with placebo and GRUPOII - pregnant rats treated with metronidazole. The metronidazole was administered daily by gavage at a dose of 130 mg / kg for 7, 14 and 21 days of gestation. The results showed that the treated group a significant reduction in the number of deployment sites, the total area of the placental disc and the constituents of the layers of the labyrinth and trofospôngio. The histochemical analysis revealed no significant changes in the content of collagen and elastic fibers and reticular. The test showed TUNEL apoptotic activity at the site of implantation and placental development 14 days regardless of treatment. We did not observe any evidence of malformation in the head, trunk and limbs of neonates. However, a significant reduction in weight and number of neonates in the group treated with metronidazole compared to control. Thus, we conclude that metronidazole in pregnant rats administered orally at a dosage of 130 mg / kg, in two thirds of early pregnancy interferes with the interaction blastocyst endometrium, in placental and fetal development, suggesting that this drug should be avoided in the early stages of pregnancy.
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spelling TEIXEIRA, Álvaro Aguiar CoelhoTEIXEIRA, Valéria WanderleySANTOS, Fábio André Brayner dosSOARES, Anísio Franciscohttp://lattes.cnpq.br/7803442906331907SILVA, Welma Emidio da2016-06-10T13:14:18Z2012-02-16SILVA, Welma Emídio da. Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas. 2012. 65 f. Dissertação (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco, Recife.http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4683Several authors have reported that metronidazole crosses the placental barrier and enters the fetal circulation and is still excreted in breast milk. Thus, not recommend the use of this drug in pregnant women and also the breastfeeding suspension for 12-24 hours after administration. However, some investigators report lack of evidence that the use of metronidazole is associated with increased risk teratogenic when administered during pregnancy is therefore unnecessary waiting for the termination of pregnancy for treatment with this drug. Thus, this study aimed to analyze the effect of administration of metronidazole during pregnancy on placental and fetal development of albino rats. 30 albino rats were used, which were divided into two groups. GROUP I - pregnant rats treated with placebo and GRUPOII - pregnant rats treated with metronidazole. The metronidazole was administered daily by gavage at a dose of 130 mg / kg for 7, 14 and 21 days of gestation. The results showed that the treated group a significant reduction in the number of deployment sites, the total area of the placental disc and the constituents of the layers of the labyrinth and trofospôngio. The histochemical analysis revealed no significant changes in the content of collagen and elastic fibers and reticular. The test showed TUNEL apoptotic activity at the site of implantation and placental development 14 days regardless of treatment. We did not observe any evidence of malformation in the head, trunk and limbs of neonates. However, a significant reduction in weight and number of neonates in the group treated with metronidazole compared to control. Thus, we conclude that metronidazole in pregnant rats administered orally at a dosage of 130 mg / kg, in two thirds of early pregnancy interferes with the interaction blastocyst endometrium, in placental and fetal development, suggesting that this drug should be avoided in the early stages of pregnancy.Vários autores relatam que o metronidazol atravessa a barreira placentária e penetra na circulação fetal, sendo ainda excretado no leite materno. Desta forma, não recomendam o uso dessa droga em mulheres gestantes e também a suspensão do aleitamento materno por 12 a 24 horas após a administração do mesmo. Entretanto alguns pesquisadores relatam faltar evidências de que o uso do metronidazol está associado com o aumento de riscos teratogênicos quando administrado durante a gestação sendo, portanto, desnecessário a espera do termino da gestação para o tratamento com essa droga. Assim, a presente pesquisa teve como objetivos analisar o efeito da administração do metronidazol durante a prenhez, sobre o desenvolvimento placentário e fetal de ratas albinas. Foram utilizadas 30 ratas albinas, que foram divididas em dois grupos. GRUPO I – ratas prenhas tratadas com placebo e GRUPOII – ratas prenhas tratadas com metronidazol. O metronidazol foi administrado por gavagem na dosagem diária de 130 mg/kg durante 7, 14 e 21 dias de gestação. Os resultados mostraram que no grupo tratado houve redução significativa do número de sítios de implantação, da área total do disco placentário e nos elementos constituintes das camadas do labirinto e trofospôngio. A análise histoquímica não revelou alterações significativas no teor de fibras colágenas, elásticas e reticulares. O teste de TUNEL mostrou atividade apoptótica nos sítios de implantação e placentas com 14 dias de desenvolvimento independente do tratamento. Não foram observados nenhum indício de malformação na cabeça, tronco e membros dos neonatos. No entanto, houve uma redução significativa no número e peso dos neonatos no grupo tratado com o metronidazol em relação ao controle. Assim, concluímos que o metronidazol administrado em ratas prenhes, por via oral, na dosagem de 130 mg/Kg, nos dois terços iniciais da gestação interfere na interação blastocisto endométrio, no desenvolvimento placentário e fetal, sugerindo que o uso desse medicamento deve ser evitado nas fases iniciais da gestação.Submitted by (lucia.rodrigues@ufrpe.br) on 2016-06-10T13:14:18Z No. of bitstreams: 1 Welma Emidio da Silva.pdf: 1500896 bytes, checksum: 7ff17715c3c5e19b309e27006eee6e14 (MD5)Made available in DSpace on 2016-06-10T13:14:18Z (GMT). No. of bitstreams: 1 Welma Emidio da Silva.pdf: 1500896 bytes, checksum: 7ff17715c3c5e19b309e27006eee6e14 (MD5) Previous issue date: 2012-02-16application/pdfporUniversidade Federal Rural de PernambucoPrograma de Pós-Graduação em Biociência AnimalUFRPEBrasilDepartamento de Morfologia e Fisiologia AnimalMetronidazolPrenhezDesenvolvimento placentárioDesenvolvimento fetalPregnancyPlacental developmentFetal developmentCIENCIAS AGRARIAS::MEDICINA VETERINARIAEfeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-1510757014399315592600600600-8922364187987396204453670264235017319info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRPEinstname:Universidade Federal Rural de Pernambuco (UFRPE)instacron:UFRPELICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/4683/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51ORIGINALWelma Emidio da Silva.pdfWelma Emidio da Silva.pdfapplication/pdf1500896http://www.tede2.ufrpe.br:8080/tede2/bitstream/tede2/4683/2/Welma+Emidio+da+Silva.pdf7ff17715c3c5e19b309e27006eee6e14MD52tede2/46832024-09-10 08:57:44.579oai:tede2: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Biblioteca Digital de Teses e Dissertaçõeshttp://www.tede2.ufrpe.br:8080/tede/PUBhttp://www.tede2.ufrpe.br:8080/oai/requestbdtd@ufrpe.br ||bdtd@ufrpe.bropendoar:2024-09-10T11:57:44Biblioteca Digital de Teses e Dissertações da UFRPE - Universidade Federal Rural de Pernambuco (UFRPE)false
dc.title.por.fl_str_mv Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas
title Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas
spellingShingle Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas
SILVA, Welma Emidio da
Metronidazol
Prenhez
Desenvolvimento placentário
Desenvolvimento fetal
Pregnancy
Placental development
Fetal development
CIENCIAS AGRARIAS::MEDICINA VETERINARIA
title_short Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas
title_full Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas
title_fullStr Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas
title_full_unstemmed Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas
title_sort Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas
author SILVA, Welma Emidio da
author_facet SILVA, Welma Emidio da
author_role author
dc.contributor.advisor1.fl_str_mv TEIXEIRA, Álvaro Aguiar Coelho
dc.contributor.advisor-co1.fl_str_mv TEIXEIRA, Valéria Wanderley
dc.contributor.referee1.fl_str_mv SANTOS, Fábio André Brayner dos
dc.contributor.referee2.fl_str_mv SOARES, Anísio Francisco
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7803442906331907
dc.contributor.author.fl_str_mv SILVA, Welma Emidio da
contributor_str_mv TEIXEIRA, Álvaro Aguiar Coelho
TEIXEIRA, Valéria Wanderley
SANTOS, Fábio André Brayner dos
SOARES, Anísio Francisco
dc.subject.por.fl_str_mv Metronidazol
Prenhez
Desenvolvimento placentário
Desenvolvimento fetal
topic Metronidazol
Prenhez
Desenvolvimento placentário
Desenvolvimento fetal
Pregnancy
Placental development
Fetal development
CIENCIAS AGRARIAS::MEDICINA VETERINARIA
dc.subject.eng.fl_str_mv Pregnancy
Placental development
Fetal development
dc.subject.cnpq.fl_str_mv CIENCIAS AGRARIAS::MEDICINA VETERINARIA
description Several authors have reported that metronidazole crosses the placental barrier and enters the fetal circulation and is still excreted in breast milk. Thus, not recommend the use of this drug in pregnant women and also the breastfeeding suspension for 12-24 hours after administration. However, some investigators report lack of evidence that the use of metronidazole is associated with increased risk teratogenic when administered during pregnancy is therefore unnecessary waiting for the termination of pregnancy for treatment with this drug. Thus, this study aimed to analyze the effect of administration of metronidazole during pregnancy on placental and fetal development of albino rats. 30 albino rats were used, which were divided into two groups. GROUP I - pregnant rats treated with placebo and GRUPOII - pregnant rats treated with metronidazole. The metronidazole was administered daily by gavage at a dose of 130 mg / kg for 7, 14 and 21 days of gestation. The results showed that the treated group a significant reduction in the number of deployment sites, the total area of the placental disc and the constituents of the layers of the labyrinth and trofospôngio. The histochemical analysis revealed no significant changes in the content of collagen and elastic fibers and reticular. The test showed TUNEL apoptotic activity at the site of implantation and placental development 14 days regardless of treatment. We did not observe any evidence of malformation in the head, trunk and limbs of neonates. However, a significant reduction in weight and number of neonates in the group treated with metronidazole compared to control. Thus, we conclude that metronidazole in pregnant rats administered orally at a dosage of 130 mg / kg, in two thirds of early pregnancy interferes with the interaction blastocyst endometrium, in placental and fetal development, suggesting that this drug should be avoided in the early stages of pregnancy.
publishDate 2012
dc.date.issued.fl_str_mv 2012-02-16
dc.date.accessioned.fl_str_mv 2016-06-10T13:14:18Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv SILVA, Welma Emídio da. Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas. 2012. 65 f. Dissertação (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco, Recife.
dc.identifier.uri.fl_str_mv http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4683
identifier_str_mv SILVA, Welma Emídio da. Efeito da administração do metronidazol durante a prenhez, sobre desenvolvimento placentário e fetal de ratas albinas. 2012. 65 f. Dissertação (Programa de Pós-Graduação em Biociência Animal) - Universidade Federal Rural de Pernambuco, Recife.
url http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4683
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dc.publisher.none.fl_str_mv Universidade Federal Rural de Pernambuco
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Biociência Animal
dc.publisher.initials.fl_str_mv UFRPE
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Departamento de Morfologia e Fisiologia Animal
publisher.none.fl_str_mv Universidade Federal Rural de Pernambuco
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