ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Revista de Atenção à Saúde |
Texto Completo: | http://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/7706 |
Resumo: | Introduction: Insulin resistance, although little investigated in individuals with type 1 diabetes mellitus, may be frequent in this population. Thus, accessible parameters to clinical practice are necessary to facilitate the screening of this condition. Objective: To evaluate the presence of insulin resistance in patients with type 1 diabetes mellitus using the triglyceride / glucose index and associate it with nutritional status, glycemic and lipid profile. Methods: Original cross-sectional study carried out with 45 adult patients (≥19 years old) treated at the Endocrinology and Diabetes outpatient clinic of a University Hospital in Fortaleza-CE. Sociodemographic, anthropometric (weight and height), biochemical and clinical data (comorbidities and pharmacological treatment) were obtained from the medical records. The cutoff points proposed for the Mexican population were used to classify the triglyceride / glucose index, considering altered, values ≥ 4.55 for women and ≥ 4.68 for men. The normality of the quantitative variables was assessed using the Shapiro Wilk test and, to investigate associations, the Student t test and the Mann-Whitney test were used. A significance level of 5% was adopted for all tests used. Results: It was observed that 62.2% of the individuals showed altered levels of the triglycerides / glucose index. Individuals who had altered levels revealed higher values of fasting blood glucose, glycated hemoglobin, triglycerides, total cholesterol and LDL-c (p <0.05). However, there was no significant association with HDL-c (p = 0.38) or with Body Mass Index (p = 0.14). Conclusions: The triglyceride / glucose index was significantly associated with fasting glycemia, glycated hemoglobin, triglycerides, total cholesterol and LDL-c. |
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ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulinaASOCIACIÓN ENTRE LA RESISTENCIA A LA INSULINA A TRAVÉS DEL ÍNDICE DE TRIGLICÉRIDOS/GLUCOSA, ESTADO NUTRICIONAL Y PERFIL LÍPIDO EN PACIENTES CON DIABETES MELLITUS TIPO 1: Diabetes mellitus tipo 1 e resistência à insulinaASSOCIAÇÃO DA RESISTÊNCIA À INSULINA EM PACIENTES PORTADORES DE DIABETES MELLITUS TIPO 1 COM O ESTADO NUTRICIONAL, PERFIL GLICÊMICO E LIPÍDICO : Diabetes mellitus tipo 1 e resistência à insulinaDoenças do Sistema Endócrino. Glicemia. Distúrbios do Metabolismo dos Lipídeos. Índice de Massa CorporalEndocrine System Diseases. Blood Glucose. Lipid Metabolism Disorders. Body Mass IndexIntroduction: Insulin resistance, although little investigated in individuals with type 1 diabetes mellitus, may be frequent in this population. Thus, accessible parameters to clinical practice are necessary to facilitate the screening of this condition. Objective: To evaluate the presence of insulin resistance in patients with type 1 diabetes mellitus using the triglyceride / glucose index and associate it with nutritional status, glycemic and lipid profile. Methods: Original cross-sectional study carried out with 45 adult patients (≥19 years old) treated at the Endocrinology and Diabetes outpatient clinic of a University Hospital in Fortaleza-CE. Sociodemographic, anthropometric (weight and height), biochemical and clinical data (comorbidities and pharmacological treatment) were obtained from the medical records. The cutoff points proposed for the Mexican population were used to classify the triglyceride / glucose index, considering altered, values ≥ 4.55 for women and ≥ 4.68 for men. The normality of the quantitative variables was assessed using the Shapiro Wilk test and, to investigate associations, the Student t test and the Mann-Whitney test were used. A significance level of 5% was adopted for all tests used. Results: It was observed that 62.2% of the individuals showed altered levels of the triglycerides / glucose index. Individuals who had altered levels revealed higher values of fasting blood glucose, glycated hemoglobin, triglycerides, total cholesterol and LDL-c (p <0.05). However, there was no significant association with HDL-c (p = 0.38) or with Body Mass Index (p = 0.14). Conclusions: The triglyceride / glucose index was significantly associated with fasting glycemia, glycated hemoglobin, triglycerides, total cholesterol and LDL-c.Introdução: A resistência à insulina, apesar de pouco investigada em indivíduos com Diabetes mellitus tipo 1, pode ser frequente nesse público. Assim, parâmetros acessíveis à prática clínica são necessários para facilitar o rastreio dessa condição. Objetivo: Avaliar a presença de resistência à insulina em pacientes com diabetes mellitus tipo 1 por meio do índice triglicerídeos/glicose e associar com estado nutricional, perfil glicêmico e lipídico. Métodos: Estudo original transversal realizado com 45 pacientes adultos (≥19 anos) atendidos no ambulatório de Endocrinologia e Diabetes de um Hospital Universitário de Fortaleza-CE. Obtiveram-se, a partir dos prontuários, dados sociodemográficos, antropométricos (peso e altura), bioquímicos e clínicos (comorbidades e tratamento farmacológico) dos pacientes. Utilizou-se os pontos de corte propostos para a população mexicana para classificação do índice triglicerídeos/glicose, considerando-se alterado, valores ≥ 4,55 para mulheres e ≥ 4,68 para homens. A normalidade das variáveis quantitativas foi avaliada por meio do teste de Shapiro Wilk e, para investigar associações utilizou-se o teste t de Student e o teste de Mann-Whitney. Adotou-se um nível de significância de 5% para todos os testes utilizados. Resultados: Observou-se que 62,22% dos indivíduos revelaram níveis alterados do índice triglicerídeos/glicose. Indivíduos que apresentaram níveis alterados revelaram valores mais elevados de glicemia de jejum, triglicerídeos e colesterol total (p<0,05). Entretanto, não se observou associação significativa com HDL-colesterol (p=0,22), LDL-colesterol (p=0,07), hemoglobina glicada (p=0,057) nem com IMC (p=0,33). Conclusões: O índice triglicerídeos/glicose associou-se significativamente com glicemia de jejum, triglicerídeos e colesterol total.Universidade Municipal de São Caetano do Sul - USCS2022-02-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/770610.13037/2359-4330.7706Journal of Health Care; Vol. 19 No. 70 (2021): Revista de Atenção à Saúde - RASRevista de Atenção à Saúde; v. 19 n. 70 (2021): Revista de Atenção à Saúde - RAS2359-4330reponame:Revista de Atenção à Saúdeinstname:Universidade Municipal de São Caetano do Sul (USCS)instacron:USCSporenghttp://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/7706/3584http://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/7706/3585Copyright (c) 2022 Mariana Pimentel Gomes Souza, Maria Yasmin Paz Teixeira Martins, Lorena Taúsz Tavares Ramos, Nathália Bernardo Marinho Leite, Synara Cavalcante Lopes, Renan Magalhães Montenegro Júniorhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessPimentel Gomes Souza, Mariana Paz Teixeira Martins, Maria Yasmin Tavares Ramos, Lorena Taúsz Bernardo Marinho Leite, Nathália Cavalcante Lopes, Synara Magalhães Montenegro Júnior, Renan2022-02-09T12:35:13Zoai:ojs2.seer.uscs.edu.br:article/7706Revistahttps://seer.uscs.edu.br/index.php/revista_ciencias_saudePUBhttp://seer.uscs.edu.br/index.php/revista_ciencias_saude/oaieditoria.ras@online.uscs.edu.br || vera.basso@online.uscs.edu.br2359-43302359-4330opendoar:2022-02-09T12:35:13Revista de Atenção à Saúde - Universidade Municipal de São Caetano do Sul (USCS)false |
dc.title.none.fl_str_mv |
ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina ASOCIACIÓN ENTRE LA RESISTENCIA A LA INSULINA A TRAVÉS DEL ÍNDICE DE TRIGLICÉRIDOS/GLUCOSA, ESTADO NUTRICIONAL Y PERFIL LÍPIDO EN PACIENTES CON DIABETES MELLITUS TIPO 1: Diabetes mellitus tipo 1 e resistência à insulina ASSOCIAÇÃO DA RESISTÊNCIA À INSULINA EM PACIENTES PORTADORES DE DIABETES MELLITUS TIPO 1 COM O ESTADO NUTRICIONAL, PERFIL GLICÊMICO E LIPÍDICO : Diabetes mellitus tipo 1 e resistência à insulina |
title |
ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina |
spellingShingle |
ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina Pimentel Gomes Souza, Mariana Doenças do Sistema Endócrino. Glicemia. Distúrbios do Metabolismo dos Lipídeos. Índice de Massa Corporal Endocrine System Diseases. Blood Glucose. Lipid Metabolism Disorders. Body Mass Index |
title_short |
ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina |
title_full |
ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina |
title_fullStr |
ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina |
title_full_unstemmed |
ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina |
title_sort |
ASSOCIATION BETWEEN INSULIN RESISTANCE ASSESSED USING THE TRIGLYCERIDE/GLUCOSE INDEX, NUTRITIONAL STATUS AND LIPID PROFILE IN PATIENTS WITH TYPE 1 DIABETES MELLITUS: Diabetes mellitus tipo 1 e resistência à insulina |
author |
Pimentel Gomes Souza, Mariana |
author_facet |
Pimentel Gomes Souza, Mariana Paz Teixeira Martins, Maria Yasmin Tavares Ramos, Lorena Taúsz Bernardo Marinho Leite, Nathália Cavalcante Lopes, Synara Magalhães Montenegro Júnior, Renan |
author_role |
author |
author2 |
Paz Teixeira Martins, Maria Yasmin Tavares Ramos, Lorena Taúsz Bernardo Marinho Leite, Nathália Cavalcante Lopes, Synara Magalhães Montenegro Júnior, Renan |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pimentel Gomes Souza, Mariana Paz Teixeira Martins, Maria Yasmin Tavares Ramos, Lorena Taúsz Bernardo Marinho Leite, Nathália Cavalcante Lopes, Synara Magalhães Montenegro Júnior, Renan |
dc.subject.por.fl_str_mv |
Doenças do Sistema Endócrino. Glicemia. Distúrbios do Metabolismo dos Lipídeos. Índice de Massa Corporal Endocrine System Diseases. Blood Glucose. Lipid Metabolism Disorders. Body Mass Index |
topic |
Doenças do Sistema Endócrino. Glicemia. Distúrbios do Metabolismo dos Lipídeos. Índice de Massa Corporal Endocrine System Diseases. Blood Glucose. Lipid Metabolism Disorders. Body Mass Index |
description |
Introduction: Insulin resistance, although little investigated in individuals with type 1 diabetes mellitus, may be frequent in this population. Thus, accessible parameters to clinical practice are necessary to facilitate the screening of this condition. Objective: To evaluate the presence of insulin resistance in patients with type 1 diabetes mellitus using the triglyceride / glucose index and associate it with nutritional status, glycemic and lipid profile. Methods: Original cross-sectional study carried out with 45 adult patients (≥19 years old) treated at the Endocrinology and Diabetes outpatient clinic of a University Hospital in Fortaleza-CE. Sociodemographic, anthropometric (weight and height), biochemical and clinical data (comorbidities and pharmacological treatment) were obtained from the medical records. The cutoff points proposed for the Mexican population were used to classify the triglyceride / glucose index, considering altered, values ≥ 4.55 for women and ≥ 4.68 for men. The normality of the quantitative variables was assessed using the Shapiro Wilk test and, to investigate associations, the Student t test and the Mann-Whitney test were used. A significance level of 5% was adopted for all tests used. Results: It was observed that 62.2% of the individuals showed altered levels of the triglycerides / glucose index. Individuals who had altered levels revealed higher values of fasting blood glucose, glycated hemoglobin, triglycerides, total cholesterol and LDL-c (p <0.05). However, there was no significant association with HDL-c (p = 0.38) or with Body Mass Index (p = 0.14). Conclusions: The triglyceride / glucose index was significantly associated with fasting glycemia, glycated hemoglobin, triglycerides, total cholesterol and LDL-c. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/7706 10.13037/2359-4330.7706 |
url |
http://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/7706 |
identifier_str_mv |
10.13037/2359-4330.7706 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
http://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/7706/3584 http://seer.uscs.edu.br/index.php/revista_ciencias_saude/article/view/7706/3585 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Municipal de São Caetano do Sul - USCS |
publisher.none.fl_str_mv |
Universidade Municipal de São Caetano do Sul - USCS |
dc.source.none.fl_str_mv |
Journal of Health Care; Vol. 19 No. 70 (2021): Revista de Atenção à Saúde - RAS Revista de Atenção à Saúde; v. 19 n. 70 (2021): Revista de Atenção à Saúde - RAS 2359-4330 reponame:Revista de Atenção à Saúde instname:Universidade Municipal de São Caetano do Sul (USCS) instacron:USCS |
instname_str |
Universidade Municipal de São Caetano do Sul (USCS) |
instacron_str |
USCS |
institution |
USCS |
reponame_str |
Revista de Atenção à Saúde |
collection |
Revista de Atenção à Saúde |
repository.name.fl_str_mv |
Revista de Atenção à Saúde - Universidade Municipal de São Caetano do Sul (USCS) |
repository.mail.fl_str_mv |
editoria.ras@online.uscs.edu.br || vera.basso@online.uscs.edu.br |
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1798042263644798976 |