Cocaine as the "causa mortis" agent

Detalhes bibliográficos
Autor(a) principal: Chasin, Alice A. da Matta
Data de Publicação: 2017
Outros Autores: Mídio, Antônio Flávio
Tipo de documento: Artigo
Idioma: por
Título da fonte: Saúde, Ética & Justiça (Online)
Texto Completo: https://www.revistas.usp.br/sej/article/view/132538
Resumo: Due to the lack of specificity, necropsy findings are not always enough to elucidate a causa mortis. Therefore, analysis of post mortem samples are object of major concern and the correct interpretation of data depends on the knowledge about the kinetics and toxicity mechanisms of the compound involved, as well as about pathologies related to the death. When cocaine is found in forensic samples, the basic cause of death is hard to be established by forensic toxicologists and pathologists, particularly if ethanol was ingested together with the drug. So, the aim of this paper was to review the most relevant aspects of cocaine and cocaethylene (product of transesterification of the drug with ethanol) toxicity to help forensic staff in the investigation related to this drugs.
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spelling Cocaine as the "causa mortis" agentCocaína como agente da causa mortisCocaineCocaethyleneLegal MedicineToxicology.CocaínaCocaetilenoMedicina LegalToxicologia.Due to the lack of specificity, necropsy findings are not always enough to elucidate a causa mortis. Therefore, analysis of post mortem samples are object of major concern and the correct interpretation of data depends on the knowledge about the kinetics and toxicity mechanisms of the compound involved, as well as about pathologies related to the death. When cocaine is found in forensic samples, the basic cause of death is hard to be established by forensic toxicologists and pathologists, particularly if ethanol was ingested together with the drug. So, the aim of this paper was to review the most relevant aspects of cocaine and cocaethylene (product of transesterification of the drug with ethanol) toxicity to help forensic staff in the investigation related to this drugs.A interpretação dos achados laboratoriais no estabelecimento da causa mortis é a integração dos conhecimentos sobre a toxicocinética, toxicodinâmica e chados necroscópicos que evidenciem ser o toxicante o responsável pelo efeito letal. Nos casos onde a cocaína é encontrada, os dados de necrópsia são, na maioria das vezes, inespecíficos, o que faz com que a determinação da causa básica do óbito constitua um desafio para os toxicologistas e patologistas forenses. A descoberta do cocaetileno, potencialmente tóxico, nos casos onde há a utilização concomitante da cocaína e etanol, adiciona elementos extras de complicação a este quadro. Dados sobre a toxicidade da cocaína e cocaetileno são abordados com a perspectiva de fornecer elementos relevantes na investigação das mortes relacionadas a este fármaco.Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Legal, Ética Médica e Medicina do Trabalho.2017-05-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionART.application/pdfhttps://www.revistas.usp.br/sej/article/view/13253810.11606/issn.2317-2770.v2i1p47-59Saúde Ética & Justiça ; v. 2 n. 1 (1997); 47-592317-2770reponame:Saúde, Ética & Justiça (Online)instname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/sej/article/view/132538/128636Copyright (c) 2017 Alice A. da Matta Chasin, Antônio Flávio Mídioinfo:eu-repo/semantics/openAccessChasin, Alice A. da MattaMídio, Antônio Flávio2020-02-14T01:17:39Zoai:revistas.usp.br:article/132538Revistahttps://www.revistas.usp.br/sej/indexPUBhttps://www.revistas.usp.br/sej/oairevistasej@fm.usp.br||2317-27701414-218Xopendoar:2020-02-14T01:17:39Saúde, Ética & Justiça (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Cocaine as the "causa mortis" agent
Cocaína como agente da causa mortis
title Cocaine as the "causa mortis" agent
spellingShingle Cocaine as the "causa mortis" agent
Chasin, Alice A. da Matta
Cocaine
Cocaethylene
Legal Medicine
Toxicology.
Cocaína
Cocaetileno
Medicina Legal
Toxicologia.
title_short Cocaine as the "causa mortis" agent
title_full Cocaine as the "causa mortis" agent
title_fullStr Cocaine as the "causa mortis" agent
title_full_unstemmed Cocaine as the "causa mortis" agent
title_sort Cocaine as the "causa mortis" agent
author Chasin, Alice A. da Matta
author_facet Chasin, Alice A. da Matta
Mídio, Antônio Flávio
author_role author
author2 Mídio, Antônio Flávio
author2_role author
dc.contributor.author.fl_str_mv Chasin, Alice A. da Matta
Mídio, Antônio Flávio
dc.subject.por.fl_str_mv Cocaine
Cocaethylene
Legal Medicine
Toxicology.
Cocaína
Cocaetileno
Medicina Legal
Toxicologia.
topic Cocaine
Cocaethylene
Legal Medicine
Toxicology.
Cocaína
Cocaetileno
Medicina Legal
Toxicologia.
description Due to the lack of specificity, necropsy findings are not always enough to elucidate a causa mortis. Therefore, analysis of post mortem samples are object of major concern and the correct interpretation of data depends on the knowledge about the kinetics and toxicity mechanisms of the compound involved, as well as about pathologies related to the death. When cocaine is found in forensic samples, the basic cause of death is hard to be established by forensic toxicologists and pathologists, particularly if ethanol was ingested together with the drug. So, the aim of this paper was to review the most relevant aspects of cocaine and cocaethylene (product of transesterification of the drug with ethanol) toxicity to help forensic staff in the investigation related to this drugs.
publishDate 2017
dc.date.none.fl_str_mv 2017-05-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
ART.
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/sej/article/view/132538
10.11606/issn.2317-2770.v2i1p47-59
url https://www.revistas.usp.br/sej/article/view/132538
identifier_str_mv 10.11606/issn.2317-2770.v2i1p47-59
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/sej/article/view/132538/128636
dc.rights.driver.fl_str_mv Copyright (c) 2017 Alice A. da Matta Chasin, Antônio Flávio Mídio
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Alice A. da Matta Chasin, Antônio Flávio Mídio
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Legal, Ética Médica e Medicina do Trabalho.
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Legal, Ética Médica e Medicina do Trabalho.
dc.source.none.fl_str_mv Saúde Ética & Justiça ; v. 2 n. 1 (1997); 47-59
2317-2770
reponame:Saúde, Ética & Justiça (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Saúde, Ética & Justiça (Online)
collection Saúde, Ética & Justiça (Online)
repository.name.fl_str_mv Saúde, Ética & Justiça (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revistasej@fm.usp.br||
_version_ 1797053621547827200

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