Altered β-catenin expression in oral mucosal dysplasia: a comparative study

Detalhes bibliográficos
Autor(a) principal: SILVA, Brunno Santos de Freitas
Data de Publicação: 2015
Outros Autores: CASTRO, Caroline Alves de, VON ZEIDLER, Sandra Lúcia Ventorin, SOUSA, Suzana Cantanhede Orsini Machado de, BATISTA, Aline Carvalho, YAMAMOTO-SILVA, Fernanda Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/106974
Resumo: Objective The current study aimed to investigate the β-catenin expression in oral leukoplakia (OL) with different degrees of epithelial dysplasia and normal oral mucosa.Material and Methods Formalin-fixed, paraffin-embedded tissue samples of 39 OL (mild dysplasia n=19, moderate dysplasia n=13, and severe dysplasia n=7), and 10 normal oral mucosa (control group) were submitted to immunohistochemical reactions to anti-β-catenin primary antibody. A qualitative β-catenin analysis was performed based on the percentage of positive cells. The cellular location and the epithelial layer were also considered. The Chi-square test and the Fisher’s exact test were used to verify possible differences in the β-catenin expression among the OL groups. A p-value of
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spelling Altered β-catenin expression in oral mucosal dysplasia: a comparative study Objective The current study aimed to investigate the β-catenin expression in oral leukoplakia (OL) with different degrees of epithelial dysplasia and normal oral mucosa.Material and Methods Formalin-fixed, paraffin-embedded tissue samples of 39 OL (mild dysplasia n=19, moderate dysplasia n=13, and severe dysplasia n=7), and 10 normal oral mucosa (control group) were submitted to immunohistochemical reactions to anti-β-catenin primary antibody. A qualitative β-catenin analysis was performed based on the percentage of positive cells. The cellular location and the epithelial layer were also considered. The Chi-square test and the Fisher’s exact test were used to verify possible differences in the β-catenin expression among the OL groups. A p-value of Universidade de São Paulo. Faculdade de Odontologia de Bauru2015-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/10697410.1590/1678-775720150150Journal of Applied Oral Science; Vol. 23 No. 5 (2015); 472-478Journal of Applied Oral Science; Vol. 23 Núm. 5 (2015); 472-478Journal of Applied Oral Science; v. 23 n. 5 (2015); 472-4781678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/106974/105546Copyright (c) 2015 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessSILVA, Brunno Santos de FreitasCASTRO, Caroline Alves deVON ZEIDLER, Sandra Lúcia VentorinSOUSA, Suzana Cantanhede Orsini Machado deBATISTA, Aline CarvalhoYAMAMOTO-SILVA, Fernanda Paula2015-11-03T11:46:22Zoai:revistas.usp.br:article/106974Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2015-11-03T11:46:22Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Altered β-catenin expression in oral mucosal dysplasia: a comparative study
title Altered β-catenin expression in oral mucosal dysplasia: a comparative study
spellingShingle Altered β-catenin expression in oral mucosal dysplasia: a comparative study
SILVA, Brunno Santos de Freitas
title_short Altered β-catenin expression in oral mucosal dysplasia: a comparative study
title_full Altered β-catenin expression in oral mucosal dysplasia: a comparative study
title_fullStr Altered β-catenin expression in oral mucosal dysplasia: a comparative study
title_full_unstemmed Altered β-catenin expression in oral mucosal dysplasia: a comparative study
title_sort Altered β-catenin expression in oral mucosal dysplasia: a comparative study
author SILVA, Brunno Santos de Freitas
author_facet SILVA, Brunno Santos de Freitas
CASTRO, Caroline Alves de
VON ZEIDLER, Sandra Lúcia Ventorin
SOUSA, Suzana Cantanhede Orsini Machado de
BATISTA, Aline Carvalho
YAMAMOTO-SILVA, Fernanda Paula
author_role author
author2 CASTRO, Caroline Alves de
VON ZEIDLER, Sandra Lúcia Ventorin
SOUSA, Suzana Cantanhede Orsini Machado de
BATISTA, Aline Carvalho
YAMAMOTO-SILVA, Fernanda Paula
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv SILVA, Brunno Santos de Freitas
CASTRO, Caroline Alves de
VON ZEIDLER, Sandra Lúcia Ventorin
SOUSA, Suzana Cantanhede Orsini Machado de
BATISTA, Aline Carvalho
YAMAMOTO-SILVA, Fernanda Paula
description Objective The current study aimed to investigate the β-catenin expression in oral leukoplakia (OL) with different degrees of epithelial dysplasia and normal oral mucosa.Material and Methods Formalin-fixed, paraffin-embedded tissue samples of 39 OL (mild dysplasia n=19, moderate dysplasia n=13, and severe dysplasia n=7), and 10 normal oral mucosa (control group) were submitted to immunohistochemical reactions to anti-β-catenin primary antibody. A qualitative β-catenin analysis was performed based on the percentage of positive cells. The cellular location and the epithelial layer were also considered. The Chi-square test and the Fisher’s exact test were used to verify possible differences in the β-catenin expression among the OL groups. A p-value of
publishDate 2015
dc.date.none.fl_str_mv 2015-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/106974
10.1590/1678-775720150150
url https://www.revistas.usp.br/jaos/article/view/106974
identifier_str_mv 10.1590/1678-775720150150
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/106974/105546
dc.rights.driver.fl_str_mv Copyright (c) 2015 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2015 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 23 No. 5 (2015); 472-478
Journal of Applied Oral Science; Vol. 23 Núm. 5 (2015); 472-478
Journal of Applied Oral Science; v. 23 n. 5 (2015); 472-478
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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