To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model

Detalhes bibliográficos
Autor(a) principal: Arpağ, Osman Fatih
Data de Publicação: 2018
Outros Autores: Damlar, Ibrahim, Altan, Ahmet, Tatli, Ufuk, Günay, Ahmet
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/142437
Resumo: ABSTRACT Among the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. Objective: To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with xenograft in rabbit calvarial bone defects. Material and methods: Ten adult male New Zealand rabbits (mean weight 3 kg) were included in the study. Three 6-mm-diameter bicortical cranial defects were created on calvarial bone of all rabbits. These defects were filled as follows: a) xenograft; b) HA+xenograft; c) autograft. One month after the first operation, rabbits were sacrificed. Specimens were evaluated histomorphometrically. Results: Considering multiple comparisons, differences regarding new bone were statistically significant between all groups (p
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spelling To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit modelHyaluronic acidXenograftHistological techniqueBone formationABSTRACT Among the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. Objective: To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with xenograft in rabbit calvarial bone defects. Material and methods: Ten adult male New Zealand rabbits (mean weight 3 kg) were included in the study. Three 6-mm-diameter bicortical cranial defects were created on calvarial bone of all rabbits. These defects were filled as follows: a) xenograft; b) HA+xenograft; c) autograft. One month after the first operation, rabbits were sacrificed. Specimens were evaluated histomorphometrically. Results: Considering multiple comparisons, differences regarding new bone were statistically significant between all groups (pUniversidade de São Paulo. Faculdade de Odontologia de Bauru2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/14243710.1590/1678-7757-2017-0004Journal of Applied Oral Science; Vol. 26 (2018); e20170004Journal of Applied Oral Science; Vol. 26 (2018); e20170004Journal of Applied Oral Science; v. 26 (2018); e201700041678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/142437/137546Copyright (c) 2018 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessArpağ, Osman FatihDamlar, IbrahimAltan, AhmetTatli, UfukGünay, Ahmet2018-03-20T12:30:06Zoai:revistas.usp.br:article/142437Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2018-03-20T12:30:06Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
title To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
spellingShingle To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
Arpağ, Osman Fatih
Hyaluronic acid
Xenograft
Histological technique
Bone formation
title_short To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
title_full To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
title_fullStr To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
title_full_unstemmed To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
title_sort To what extent does hyaluronic acid affect healing of xenografts? A histomorphometric study in a rabbit model
author Arpağ, Osman Fatih
author_facet Arpağ, Osman Fatih
Damlar, Ibrahim
Altan, Ahmet
Tatli, Ufuk
Günay, Ahmet
author_role author
author2 Damlar, Ibrahim
Altan, Ahmet
Tatli, Ufuk
Günay, Ahmet
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Arpağ, Osman Fatih
Damlar, Ibrahim
Altan, Ahmet
Tatli, Ufuk
Günay, Ahmet
dc.subject.por.fl_str_mv Hyaluronic acid
Xenograft
Histological technique
Bone formation
topic Hyaluronic acid
Xenograft
Histological technique
Bone formation
description ABSTRACT Among the many graft materials that have been used for the treatment of bone defects in oral and maxillofacial regions is xenograft. To improve osteoconductive effects of xenografts, they have been combined with various biocompatible materials, such as hyaluronic acid and bone morphogenetic protein. Objective: To determine bone-healing capacity of high molecular weight hyaluronic acid (HA) combined with xenograft in rabbit calvarial bone defects. Material and methods: Ten adult male New Zealand rabbits (mean weight 3 kg) were included in the study. Three 6-mm-diameter bicortical cranial defects were created on calvarial bone of all rabbits. These defects were filled as follows: a) xenograft; b) HA+xenograft; c) autograft. One month after the first operation, rabbits were sacrificed. Specimens were evaluated histomorphometrically. Results: Considering multiple comparisons, differences regarding new bone were statistically significant between all groups (p
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/142437
10.1590/1678-7757-2017-0004
url https://www.revistas.usp.br/jaos/article/view/142437
identifier_str_mv 10.1590/1678-7757-2017-0004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/142437/137546
dc.rights.driver.fl_str_mv Copyright (c) 2018 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 26 (2018); e20170004
Journal of Applied Oral Science; Vol. 26 (2018); e20170004
Journal of Applied Oral Science; v. 26 (2018); e20170004
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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