Effect of collagen sponge and fibrin glue on bone repair

Detalhes bibliográficos
Autor(a) principal: SANTOS,Thiago de Santana
Data de Publicação: 2015
Outros Autores: ABUNA,Rodrigo Paolo Flores, ALMEIDA,Adriana Luisa Gonçalves de, BELOTI,Marcio Mateus, ROSA,Adalberto Luiz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572015000600623
Resumo: ABSTRACT The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. Objective In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. Material and Methods Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). Results Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. Conclusion Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous.
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spelling Effect of collagen sponge and fibrin glue on bone repairBoneCollagen spongeFibrin glueHemostatic agentABSTRACT The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. Objective In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. Material and Methods Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). Results Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. Conclusion Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous.Faculdade De Odontologia De Bauru - USP2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572015000600623Journal of Applied Oral Science v.23 n.6 2015reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/1678-775720150374info:eu-repo/semantics/openAccessSANTOS,Thiago de SantanaABUNA,Rodrigo Paolo FloresALMEIDA,Adriana Luisa Gonçalves deBELOTI,Marcio MateusROSA,Adalberto Luizeng2016-05-12T00:00:00Zoai:scielo:S1678-77572015000600623Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2016-05-12T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Effect of collagen sponge and fibrin glue on bone repair
title Effect of collagen sponge and fibrin glue on bone repair
spellingShingle Effect of collagen sponge and fibrin glue on bone repair
SANTOS,Thiago de Santana
Bone
Collagen sponge
Fibrin glue
Hemostatic agent
title_short Effect of collagen sponge and fibrin glue on bone repair
title_full Effect of collagen sponge and fibrin glue on bone repair
title_fullStr Effect of collagen sponge and fibrin glue on bone repair
title_full_unstemmed Effect of collagen sponge and fibrin glue on bone repair
title_sort Effect of collagen sponge and fibrin glue on bone repair
author SANTOS,Thiago de Santana
author_facet SANTOS,Thiago de Santana
ABUNA,Rodrigo Paolo Flores
ALMEIDA,Adriana Luisa Gonçalves de
BELOTI,Marcio Mateus
ROSA,Adalberto Luiz
author_role author
author2 ABUNA,Rodrigo Paolo Flores
ALMEIDA,Adriana Luisa Gonçalves de
BELOTI,Marcio Mateus
ROSA,Adalberto Luiz
author2_role author
author
author
author
dc.contributor.author.fl_str_mv SANTOS,Thiago de Santana
ABUNA,Rodrigo Paolo Flores
ALMEIDA,Adriana Luisa Gonçalves de
BELOTI,Marcio Mateus
ROSA,Adalberto Luiz
dc.subject.por.fl_str_mv Bone
Collagen sponge
Fibrin glue
Hemostatic agent
topic Bone
Collagen sponge
Fibrin glue
Hemostatic agent
description ABSTRACT The ability of hemostatic agents to promote bone repair has been investigated using in vitro and in vivo models but, up to now, the results are inconclusive. Objective In this context, the aim of this study was to compare the potential of bone repair of collagen sponge with fibrin glue in a rat calvarial defect model. Material and Methods Defects of 5 mm in diameter were created in rat calvariae and treated with either collagen sponge or fibrin glue; untreated defects were used as control. At 4 and 8 weeks, histological analysis and micro-CT-based histomorphometry were carried out and data were compared by two-way ANOVA followed by Student-Newman-Keuls test when appropriated (p≤0.05). Results Three-dimensional reconstructions showed increased bone formation in defects treated with either collagen sponge or fibrin glue compared with untreated defects, which was confirmed by the histological analysis. Morphometric parameters indicated the progression of bone formation from 4 to 8 weeks. Additionally, fibrin glue displayed slightly higher bone formation rate when compared with collagen sponge. Conclusion Our results have shown the benefits of using collagen sponge and fibrin glue to promote new bone formation in rat calvarial bone defects, the latter being discreetly more advantageous.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572015000600623
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572015000600623
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-775720150374
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.23 n.6 2015
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
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