Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride

Detalhes bibliográficos
Autor(a) principal: Carvalho, Juliane Guimarães de
Data de Publicação: 2006
Outros Autores: Oliveira, Rodrigo Cardoso de, Buzalaf, Marília Afonso Rabelo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
DOI: 10.1590/S1678-77572006000400005
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3378
Resumo: OBJECTIVE: This study evaluated the use of plasma, bone surface (periosteal) and whole bone as biomarkers of chronic fluoride (F) exposure. METHODS: Forty male Wistar rats were assigned to 4 groups (n=10/gr) that differed according to the F concentration they received in the drinking water. Groups 1, 2, 3 and 4 received water containing 0 (control), 5, 15, and 50 mg F/L, respectively. The rats were killed at 120 days of age. Plasma and femur were collected and analyzed for fluoride with the ion specific electrode by the direct method or after hexamethyldisiloxane-facilitated diffusion. Data were tested for statistically significant differences by ANOVA and linear regression (p
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spelling Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride Plasma como um indicador dos níveis de flúor no osso em ratos expostos cronicamente ao flúor FlúorOssoPlasmaBiomarcadoresFluorideBonePlasmaBiomarkers OBJECTIVE: This study evaluated the use of plasma, bone surface (periosteal) and whole bone as biomarkers of chronic fluoride (F) exposure. METHODS: Forty male Wistar rats were assigned to 4 groups (n=10/gr) that differed according to the F concentration they received in the drinking water. Groups 1, 2, 3 and 4 received water containing 0 (control), 5, 15, and 50 mg F/L, respectively. The rats were killed at 120 days of age. Plasma and femur were collected and analyzed for fluoride with the ion specific electrode by the direct method or after hexamethyldisiloxane-facilitated diffusion. Data were tested for statistically significant differences by ANOVA and linear regression (p OBJETIVOS: Este estudo avaliou o uso do plasma, superfície óssea e osso total como biomarcadores da exposição crônica ao flúor em ratos. MÉTODOS: Quarenta ratos Wistar machos foram divididos em 4 grupos (n=10/gr) que diferiram de acordo com a concentração de flúor presente na água de beber. Os grupos 1, 2, 3 e 4 receberam água contendo 0, 5, 15 e 50 mg F/L, respectivamente. Os ratos foram mortos ao completarem 120 dias. O plasma e os fêmures foram coletados e a concentração de flúor foi analisada com um eletrodo específico pelo método direto para a superfície do fêmur e após difusão facilitada por HMDS para o osso total e o plasma. Os dados foram analisados por ANOVA e regressão linear (pUniversidade de São Paulo. Faculdade de Odontologia de Bauru2006-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/337810.1590/S1678-77572006000400005Journal of Applied Oral Science; Vol. 14 No. 4 (2006); 238-241 Journal of Applied Oral Science; Vol. 14 Núm. 4 (2006); 238-241 Journal of Applied Oral Science; v. 14 n. 4 (2006); 238-241 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3378/4068Copyright (c) 2006 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessCarvalho, Juliane Guimarães deOliveira, Rodrigo Cardoso deBuzalaf, Marília Afonso Rabelo2012-04-27T11:54:21Zoai:revistas.usp.br:article/3378Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T11:54:21Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
Plasma como um indicador dos níveis de flúor no osso em ratos expostos cronicamente ao flúor
title Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
spellingShingle Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
Carvalho, Juliane Guimarães de
Flúor
Osso
Plasma
Biomarcadores
Fluoride
Bone
Plasma
Biomarkers
Carvalho, Juliane Guimarães de
Flúor
Osso
Plasma
Biomarcadores
Fluoride
Bone
Plasma
Biomarkers
title_short Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
title_full Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
title_fullStr Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
title_full_unstemmed Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
title_sort Plasma as an indicator of bone fluoride levels in rats chronically exposed to fluoride
author Carvalho, Juliane Guimarães de
author_facet Carvalho, Juliane Guimarães de
Carvalho, Juliane Guimarães de
Oliveira, Rodrigo Cardoso de
Buzalaf, Marília Afonso Rabelo
Oliveira, Rodrigo Cardoso de
Buzalaf, Marília Afonso Rabelo
author_role author
author2 Oliveira, Rodrigo Cardoso de
Buzalaf, Marília Afonso Rabelo
author2_role author
author
dc.contributor.author.fl_str_mv Carvalho, Juliane Guimarães de
Oliveira, Rodrigo Cardoso de
Buzalaf, Marília Afonso Rabelo
dc.subject.por.fl_str_mv Flúor
Osso
Plasma
Biomarcadores
Fluoride
Bone
Plasma
Biomarkers
topic Flúor
Osso
Plasma
Biomarcadores
Fluoride
Bone
Plasma
Biomarkers
description OBJECTIVE: This study evaluated the use of plasma, bone surface (periosteal) and whole bone as biomarkers of chronic fluoride (F) exposure. METHODS: Forty male Wistar rats were assigned to 4 groups (n=10/gr) that differed according to the F concentration they received in the drinking water. Groups 1, 2, 3 and 4 received water containing 0 (control), 5, 15, and 50 mg F/L, respectively. The rats were killed at 120 days of age. Plasma and femur were collected and analyzed for fluoride with the ion specific electrode by the direct method or after hexamethyldisiloxane-facilitated diffusion. Data were tested for statistically significant differences by ANOVA and linear regression (p
publishDate 2006
dc.date.none.fl_str_mv 2006-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3378
10.1590/S1678-77572006000400005
url https://www.revistas.usp.br/jaos/article/view/3378
identifier_str_mv 10.1590/S1678-77572006000400005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3378/4068
dc.rights.driver.fl_str_mv Copyright (c) 2006 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2006 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 14 No. 4 (2006); 238-241
Journal of Applied Oral Science; Vol. 14 Núm. 4 (2006); 238-241
Journal of Applied Oral Science; v. 14 n. 4 (2006); 238-241
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
_version_ 1822179117969178624
dc.identifier.doi.none.fl_str_mv 10.1590/S1678-77572006000400005

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