Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/206651 |
Resumo: | Nociceptive and inflammatory orofacial pain is highly prevalent in the population, which justifies the search for safer analgesics. There is increasing evidence of the analgesic and anxiolytic potential of Lavandula angustifolia essential oil (LAV EO), which may represent, when administered through inhalation, may represent a safer alternative for pain treatment. Objective: to evaluate whether LAV EO has antinociceptive effect in the formalin test, and anti-hyperalgesic and anxiolytic-like effects in rats subjected to a model of orofacial postoperative pain. Methodology: Female Wistar rats were exposed to LAV EO (5%) by inhalation for 30 minutes. After exposure, animals were injected with formalin (2.5%, 50 μL) or saline into the hind paw or upper lip and the number of flinches or facial grooming time, respectively, were evaluated. Likewise, on day 3 after intraoral mucosa incision, the animals were exposed to LAV EO and facial mechanical, and heat hyperalgesia were assessed. The influence of LAV EO inhalation on anxiety-like behavior was assessed in operated rats by testing them on the open field (OF) and elevated plus maze (EPM). Results: LAV EO reduced the phase II of the paw formalin test and both phases of the orofacial formalin test. On day three post-incision, LAV EO reduced heat and mechanical hyperalgesia, from 30 minutes up to three hours, and reduced the anxiety-like behavior in operated rats without causing locomotor deficit. Conclusion: LAV EO inhalation results in antinociceptive and anxiolytic-like effects in orofacial pain models, which encourages further studies on LAV EO indications and effectiveness on orofacial pain conditions. |
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Journal of applied oral science (Online) |
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Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial painNasal administrationPostoperative painNociceptive orofacial painAnxietyHyperalgesiaNociceptive and inflammatory orofacial pain is highly prevalent in the population, which justifies the search for safer analgesics. There is increasing evidence of the analgesic and anxiolytic potential of Lavandula angustifolia essential oil (LAV EO), which may represent, when administered through inhalation, may represent a safer alternative for pain treatment. Objective: to evaluate whether LAV EO has antinociceptive effect in the formalin test, and anti-hyperalgesic and anxiolytic-like effects in rats subjected to a model of orofacial postoperative pain. Methodology: Female Wistar rats were exposed to LAV EO (5%) by inhalation for 30 minutes. After exposure, animals were injected with formalin (2.5%, 50 μL) or saline into the hind paw or upper lip and the number of flinches or facial grooming time, respectively, were evaluated. Likewise, on day 3 after intraoral mucosa incision, the animals were exposed to LAV EO and facial mechanical, and heat hyperalgesia were assessed. The influence of LAV EO inhalation on anxiety-like behavior was assessed in operated rats by testing them on the open field (OF) and elevated plus maze (EPM). Results: LAV EO reduced the phase II of the paw formalin test and both phases of the orofacial formalin test. On day three post-incision, LAV EO reduced heat and mechanical hyperalgesia, from 30 minutes up to three hours, and reduced the anxiety-like behavior in operated rats without causing locomotor deficit. Conclusion: LAV EO inhalation results in antinociceptive and anxiolytic-like effects in orofacial pain models, which encourages further studies on LAV EO indications and effectiveness on orofacial pain conditions.Universidade de São Paulo. Faculdade de Odontologia de Bauru2023-01-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/20665110.1590/1678-7757-2002-0304Journal of Applied Oral Science; Vol. 30 (2022); e20220304Journal of Applied Oral Science; Vol. 30 (2022); e20220304Journal of Applied Oral Science; v. 30 (2022); e202203041678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/206651/190365Copyright (c) 2023 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessChichorro, Juliana GeremiasZanoveli, Janaina Menezes Koren, Laura de OliveiraBaggio, Darciane Favero Lopes, Raphael Vieira Lejune, Vanessa Bordenowsky Pereira2023-01-10T18:04:49Zoai:revistas.usp.br:article/206651Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2023-01-10T18:04:49Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
title |
Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
spellingShingle |
Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain Chichorro, Juliana Geremias Nasal administration Postoperative pain Nociceptive orofacial pain Anxiety Hyperalgesia |
title_short |
Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
title_full |
Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
title_fullStr |
Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
title_full_unstemmed |
Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
title_sort |
Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain |
author |
Chichorro, Juliana Geremias |
author_facet |
Chichorro, Juliana Geremias Zanoveli, Janaina Menezes Koren, Laura de Oliveira Baggio, Darciane Favero Lopes, Raphael Vieira Lejune, Vanessa Bordenowsky Pereira |
author_role |
author |
author2 |
Zanoveli, Janaina Menezes Koren, Laura de Oliveira Baggio, Darciane Favero Lopes, Raphael Vieira Lejune, Vanessa Bordenowsky Pereira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Chichorro, Juliana Geremias Zanoveli, Janaina Menezes Koren, Laura de Oliveira Baggio, Darciane Favero Lopes, Raphael Vieira Lejune, Vanessa Bordenowsky Pereira |
dc.subject.por.fl_str_mv |
Nasal administration Postoperative pain Nociceptive orofacial pain Anxiety Hyperalgesia |
topic |
Nasal administration Postoperative pain Nociceptive orofacial pain Anxiety Hyperalgesia |
description |
Nociceptive and inflammatory orofacial pain is highly prevalent in the population, which justifies the search for safer analgesics. There is increasing evidence of the analgesic and anxiolytic potential of Lavandula angustifolia essential oil (LAV EO), which may represent, when administered through inhalation, may represent a safer alternative for pain treatment. Objective: to evaluate whether LAV EO has antinociceptive effect in the formalin test, and anti-hyperalgesic and anxiolytic-like effects in rats subjected to a model of orofacial postoperative pain. Methodology: Female Wistar rats were exposed to LAV EO (5%) by inhalation for 30 minutes. After exposure, animals were injected with formalin (2.5%, 50 μL) or saline into the hind paw or upper lip and the number of flinches or facial grooming time, respectively, were evaluated. Likewise, on day 3 after intraoral mucosa incision, the animals were exposed to LAV EO and facial mechanical, and heat hyperalgesia were assessed. The influence of LAV EO inhalation on anxiety-like behavior was assessed in operated rats by testing them on the open field (OF) and elevated plus maze (EPM). Results: LAV EO reduced the phase II of the paw formalin test and both phases of the orofacial formalin test. On day three post-incision, LAV EO reduced heat and mechanical hyperalgesia, from 30 minutes up to three hours, and reduced the anxiety-like behavior in operated rats without causing locomotor deficit. Conclusion: LAV EO inhalation results in antinociceptive and anxiolytic-like effects in orofacial pain models, which encourages further studies on LAV EO indications and effectiveness on orofacial pain conditions. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/206651 10.1590/1678-7757-2002-0304 |
url |
https://www.revistas.usp.br/jaos/article/view/206651 |
identifier_str_mv |
10.1590/1678-7757-2002-0304 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/206651/190365 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 30 (2022); e20220304 Journal of Applied Oral Science; Vol. 30 (2022); e20220304 Journal of Applied Oral Science; v. 30 (2022); e20220304 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221683314851840 |