Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000600017 |
Resumo: | OBJECTIVE: The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. MATERIAL AND METHODS: In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). RESULTS: In the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm², 0.57±0.14 mm², 0.62±0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm²; 1.40±0.31 mm²; 1.29±0.27 mm²), respectively. CONCLUSIONS: Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats. |
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Journal of applied oral science (Online) |
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Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in ratsIrrigationPeriodontal diseasesPeriodontitisRatsTetracyclineOBJECTIVE: The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. MATERIAL AND METHODS: In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). RESULTS: In the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm², 0.57±0.14 mm², 0.62±0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm²; 1.40±0.31 mm²; 1.29±0.27 mm²), respectively. CONCLUSIONS: Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.Faculdade De Odontologia De Bauru - USP2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000600017Journal of Applied Oral Science v.18 n.6 2010reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572010000600017info:eu-repo/semantics/openAccessFernandes,Leandro AraújoMartins,Thiago MarchiAlmeida,Juliano Milanezi DeNagata,Maria José HitomiTheodoro,Leticia HelenaGarcia,Valdir GouveiaBosco,Alvaro Franciscoeng2011-01-14T00:00:00Zoai:scielo:S1678-77572010000600017Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2011-01-14T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats |
title |
Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats |
spellingShingle |
Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats Fernandes,Leandro Araújo Irrigation Periodontal diseases Periodontitis Rats Tetracycline |
title_short |
Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats |
title_full |
Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats |
title_fullStr |
Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats |
title_full_unstemmed |
Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats |
title_sort |
Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats |
author |
Fernandes,Leandro Araújo |
author_facet |
Fernandes,Leandro Araújo Martins,Thiago Marchi Almeida,Juliano Milanezi De Nagata,Maria José Hitomi Theodoro,Leticia Helena Garcia,Valdir Gouveia Bosco,Alvaro Francisco |
author_role |
author |
author2 |
Martins,Thiago Marchi Almeida,Juliano Milanezi De Nagata,Maria José Hitomi Theodoro,Leticia Helena Garcia,Valdir Gouveia Bosco,Alvaro Francisco |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Fernandes,Leandro Araújo Martins,Thiago Marchi Almeida,Juliano Milanezi De Nagata,Maria José Hitomi Theodoro,Leticia Helena Garcia,Valdir Gouveia Bosco,Alvaro Francisco |
dc.subject.por.fl_str_mv |
Irrigation Periodontal diseases Periodontitis Rats Tetracycline |
topic |
Irrigation Periodontal diseases Periodontitis Rats Tetracycline |
description |
OBJECTIVE: The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. MATERIAL AND METHODS: In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). RESULTS: In the histometric analysis, at 7, 15 and 30 days, Group T (0.72±0.05 mm², 0.57±0.14 mm², 0.62±0.07 mm²), showed less bone loss (p<0.05) than Group C (1.35±0.25 mm²; 1.40±0.31 mm²; 1.29±0.27 mm²), respectively. CONCLUSIONS: Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000600017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572010000600017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1678-77572010000600017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science v.18 n.6 2010 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1748936436193689600 |