Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of applied oral science (Online) |
Texto Completo: | https://www.revistas.usp.br/jaos/article/view/190155 |
Resumo: | Objectives: This study evaluated if the use of a bioactive glass-ceramic-based gel, named Biosilicate (BS), before, after or mixed with bleaching gel, could influence the inflammation of the dental pulp tissue of rats’ molars undergoing dental bleaching with hydrogen peroxide (H2O2). Methodology: The upper molars of Wistar rats (Rattus norvegicus, albinus) were divided into Ble: bleached (35% H2O2, 30-min); Ble-BS: bleached and followed by BS-based gel application (20 min); BS-Ble: BS-based gel application and then bleaching; BS/7d-Ble: BS-based gel applications for 7 days and then bleaching; Ble+BS: blend of H2O2 with BS-based gel (1:1, 30-min); and control: placebo gel. After 2 and 30 days (n=10), the rats were euthanized for histological evaluation. The Kruskal-Wallis and Dunn statistical tests were performed (P<0.05). Results: At 2 days, the Ble and Ble-BS groups had significant alterations in the pulp tissue, with an area of necrosis. The groups with the application of BS-based gel before H2O2 had moderate inflammation and partial disorganization in the occlusal third of the coronary pulp and were significantly different from the Ble in the middle and cervical thirds (P<0.05). The most favorable results were observed in the Ble+BS, which was similar to the control in all thirds of the coronary pulp (P>0.05). At 30 days, the pulp tissue was organized and the bleached groups presented tertiary dentin deposition. The Ble group had the highest deposition of tertiary dentin, followed by the Ble-BS, and both were different from control (P<0.05). Conclusion: A single BS-based gel application beforehand or BS-based gel blended with a bleaching gel minimize the pulp damage induced by dental bleaching. |
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Journal of applied oral science (Online) |
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Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in ratsBioactive glassDental pulpHydrogen peroxideTooth bleachingTooth remineralizationObjectives: This study evaluated if the use of a bioactive glass-ceramic-based gel, named Biosilicate (BS), before, after or mixed with bleaching gel, could influence the inflammation of the dental pulp tissue of rats’ molars undergoing dental bleaching with hydrogen peroxide (H2O2). Methodology: The upper molars of Wistar rats (Rattus norvegicus, albinus) were divided into Ble: bleached (35% H2O2, 30-min); Ble-BS: bleached and followed by BS-based gel application (20 min); BS-Ble: BS-based gel application and then bleaching; BS/7d-Ble: BS-based gel applications for 7 days and then bleaching; Ble+BS: blend of H2O2 with BS-based gel (1:1, 30-min); and control: placebo gel. After 2 and 30 days (n=10), the rats were euthanized for histological evaluation. The Kruskal-Wallis and Dunn statistical tests were performed (P<0.05). Results: At 2 days, the Ble and Ble-BS groups had significant alterations in the pulp tissue, with an area of necrosis. The groups with the application of BS-based gel before H2O2 had moderate inflammation and partial disorganization in the occlusal third of the coronary pulp and were significantly different from the Ble in the middle and cervical thirds (P<0.05). The most favorable results were observed in the Ble+BS, which was similar to the control in all thirds of the coronary pulp (P>0.05). At 30 days, the pulp tissue was organized and the bleached groups presented tertiary dentin deposition. The Ble group had the highest deposition of tertiary dentin, followed by the Ble-BS, and both were different from control (P<0.05). Conclusion: A single BS-based gel application beforehand or BS-based gel blended with a bleaching gel minimize the pulp damage induced by dental bleaching.Universidade de São Paulo. Faculdade de Odontologia de Bauru2021-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/19015510.1590/1678-7757-2019-0384Journal of Applied Oral Science; Vol. 28 (2020); e20190384Journal of Applied Oral Science; Vol. 28 (2020); e20190384Journal of Applied Oral Science; v. 28 (2020); e201903841678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/190155/175542Copyright (c) 2021 Journal of Applied Oral Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarminatti, Marina Benetti, Francine Siqueira, Renato Luiz Zanotto, Edgar Dutra Briso, André Luiz Fraga Chaves-Neto, Antônio Hernandes Cintra, Luciano Tavares Angelo 2021-08-30T17:31:17Zoai:revistas.usp.br:article/190155Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2021-08-30T17:31:17Journal of applied oral science (Online) - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
title |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
spellingShingle |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats Carminatti, Marina Bioactive glass Dental pulp Hydrogen peroxide Tooth bleaching Tooth remineralization |
title_short |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
title_full |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
title_fullStr |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
title_full_unstemmed |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
title_sort |
Experimental gel containing bioactive glass-ceramic to minimize the pulp damage caused by dental bleaching in rats |
author |
Carminatti, Marina |
author_facet |
Carminatti, Marina Benetti, Francine Siqueira, Renato Luiz Zanotto, Edgar Dutra Briso, André Luiz Fraga Chaves-Neto, Antônio Hernandes Cintra, Luciano Tavares Angelo |
author_role |
author |
author2 |
Benetti, Francine Siqueira, Renato Luiz Zanotto, Edgar Dutra Briso, André Luiz Fraga Chaves-Neto, Antônio Hernandes Cintra, Luciano Tavares Angelo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Carminatti, Marina Benetti, Francine Siqueira, Renato Luiz Zanotto, Edgar Dutra Briso, André Luiz Fraga Chaves-Neto, Antônio Hernandes Cintra, Luciano Tavares Angelo |
dc.subject.por.fl_str_mv |
Bioactive glass Dental pulp Hydrogen peroxide Tooth bleaching Tooth remineralization |
topic |
Bioactive glass Dental pulp Hydrogen peroxide Tooth bleaching Tooth remineralization |
description |
Objectives: This study evaluated if the use of a bioactive glass-ceramic-based gel, named Biosilicate (BS), before, after or mixed with bleaching gel, could influence the inflammation of the dental pulp tissue of rats’ molars undergoing dental bleaching with hydrogen peroxide (H2O2). Methodology: The upper molars of Wistar rats (Rattus norvegicus, albinus) were divided into Ble: bleached (35% H2O2, 30-min); Ble-BS: bleached and followed by BS-based gel application (20 min); BS-Ble: BS-based gel application and then bleaching; BS/7d-Ble: BS-based gel applications for 7 days and then bleaching; Ble+BS: blend of H2O2 with BS-based gel (1:1, 30-min); and control: placebo gel. After 2 and 30 days (n=10), the rats were euthanized for histological evaluation. The Kruskal-Wallis and Dunn statistical tests were performed (P<0.05). Results: At 2 days, the Ble and Ble-BS groups had significant alterations in the pulp tissue, with an area of necrosis. The groups with the application of BS-based gel before H2O2 had moderate inflammation and partial disorganization in the occlusal third of the coronary pulp and were significantly different from the Ble in the middle and cervical thirds (P<0.05). The most favorable results were observed in the Ble+BS, which was similar to the control in all thirds of the coronary pulp (P>0.05). At 30 days, the pulp tissue was organized and the bleached groups presented tertiary dentin deposition. The Ble group had the highest deposition of tertiary dentin, followed by the Ble-BS, and both were different from control (P<0.05). Conclusion: A single BS-based gel application beforehand or BS-based gel blended with a bleaching gel minimize the pulp damage induced by dental bleaching. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/190155 10.1590/1678-7757-2019-0384 |
url |
https://www.revistas.usp.br/jaos/article/view/190155 |
identifier_str_mv |
10.1590/1678-7757-2019-0384 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/jaos/article/view/190155/175542 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Journal of Applied Oral Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Odontologia de Bauru |
dc.source.none.fl_str_mv |
Journal of Applied Oral Science; Vol. 28 (2020); e20190384 Journal of Applied Oral Science; Vol. 28 (2020); e20190384 Journal of Applied Oral Science; v. 28 (2020); e20190384 1678-7765 1678-7757 reponame:Journal of applied oral science (Online) instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Journal of applied oral science (Online) |
collection |
Journal of applied oral science (Online) |
repository.name.fl_str_mv |
Journal of applied oral science (Online) - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||jaos@usp.br |
_version_ |
1800221681962188800 |