Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems

Detalhes bibliográficos
Autor(a) principal: Gahyva,Sérgio Márcio Motta
Data de Publicação: 2005
Outros Autores: Siqueira Junior,José Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000400014
Resumo: Substances and materials used in endodontic therapy come into close contact with the periradicular tissues via apical foramen and foramina. Consequently, they should possess biocompatibility. There are currently few studies describing the genotoxic and mutagenic potentials of substances and materials used in endodontics. The purpose of this study was to evaluate the direct genotoxic and mutagenic properties of several substances and materials used in different phases of the endodontic treatment. For this intent, two prokaryotic test systems were used: the SOS chromotest and the Ames test. No metabolization with S9 was investigated, since only the direct effects of the substances and materials were surveyed. Most of the substances and materials tested presented mild to moderate cytotoxicity and genotoxicity as revealed by the SOS chromotest. Formocresol was the only tested substance to present severe genotoxicity to the tester bacterial strains. However, no substance or material tested showed direct mutagenicity as revealed by the Ames test.
id USP-17_bdf7a07d1305fc2944faa7db2009c47c
oai_identifier_str oai:scielo:S1678-77572005000400014
network_acronym_str USP-17
network_name_str Journal of applied oral science (Online)
repository_id_str
spelling Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systemsRoot canal therapyIntracanal medicationRoot canal irrigantsRoot canal filling materialsGenotoxycity testsMutagenicity testsSubstances and materials used in endodontic therapy come into close contact with the periradicular tissues via apical foramen and foramina. Consequently, they should possess biocompatibility. There are currently few studies describing the genotoxic and mutagenic potentials of substances and materials used in endodontics. The purpose of this study was to evaluate the direct genotoxic and mutagenic properties of several substances and materials used in different phases of the endodontic treatment. For this intent, two prokaryotic test systems were used: the SOS chromotest and the Ames test. No metabolization with S9 was investigated, since only the direct effects of the substances and materials were surveyed. Most of the substances and materials tested presented mild to moderate cytotoxicity and genotoxicity as revealed by the SOS chromotest. Formocresol was the only tested substance to present severe genotoxicity to the tester bacterial strains. However, no substance or material tested showed direct mutagenicity as revealed by the Ames test.Faculdade De Odontologia De Bauru - USP2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000400014Journal of Applied Oral Science v.13 n.4 2005reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USP10.1590/S1678-77572005000400014info:eu-repo/semantics/openAccessGahyva,Sérgio Márcio MottaSiqueira Junior,José Freitaseng2006-01-20T00:00:00Zoai:scielo:S1678-77572005000400014Revistahttp://www.scielo.br/jaosPUBhttps://old.scielo.br/oai/scielo-oai.php||jaos@usp.br1678-77651678-7757opendoar:2006-01-20T00:00Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
title Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
spellingShingle Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
Gahyva,Sérgio Márcio Motta
Root canal therapy
Intracanal medication
Root canal irrigants
Root canal filling materials
Genotoxycity tests
Mutagenicity tests
title_short Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
title_full Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
title_fullStr Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
title_full_unstemmed Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
title_sort Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
author Gahyva,Sérgio Márcio Motta
author_facet Gahyva,Sérgio Márcio Motta
Siqueira Junior,José Freitas
author_role author
author2 Siqueira Junior,José Freitas
author2_role author
dc.contributor.author.fl_str_mv Gahyva,Sérgio Márcio Motta
Siqueira Junior,José Freitas
dc.subject.por.fl_str_mv Root canal therapy
Intracanal medication
Root canal irrigants
Root canal filling materials
Genotoxycity tests
Mutagenicity tests
topic Root canal therapy
Intracanal medication
Root canal irrigants
Root canal filling materials
Genotoxycity tests
Mutagenicity tests
description Substances and materials used in endodontic therapy come into close contact with the periradicular tissues via apical foramen and foramina. Consequently, they should possess biocompatibility. There are currently few studies describing the genotoxic and mutagenic potentials of substances and materials used in endodontics. The purpose of this study was to evaluate the direct genotoxic and mutagenic properties of several substances and materials used in different phases of the endodontic treatment. For this intent, two prokaryotic test systems were used: the SOS chromotest and the Ames test. No metabolization with S9 was investigated, since only the direct effects of the substances and materials were surveyed. Most of the substances and materials tested presented mild to moderate cytotoxicity and genotoxicity as revealed by the SOS chromotest. Formocresol was the only tested substance to present severe genotoxicity to the tester bacterial strains. However, no substance or material tested showed direct mutagenicity as revealed by the Ames test.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000400014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000400014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-77572005000400014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv Journal of Applied Oral Science v.13 n.4 2005
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
_version_ 1748936433950785536

Registros relacionados