The effects on mucociliary clearance of prednisone associated with bronchial section
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/40021 |
Resumo: | OBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance. METHODS: A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy: prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated. RESULTS: Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (p |
id |
USP-19_0ed44f4c2dc5fb95eb78ebc047d47f38 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/40021 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
The effects on mucociliary clearance of prednisone associated with bronchial sectionPrednisoneMucociliary clearanceBronchiLung transplantationImmunosuppressionOBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance. METHODS: A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy: prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated. RESULTS: Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4002110.6061/clinics/2012(06)16Clinics; Vol. 67 No. 6 (2012); 647-652Clinics; v. 67 n. 6 (2012); 647-652Clinics; Vol. 67 Núm. 6 (2012); 647-6521980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/40021/42886Braga, Karina Andrighetti de OliveiraNepomuceno, Natalia AparecidaCorreia, Aristides TadeuJatene, Fabio BiscegliPêgo-Fernandes, Paulo Manuelinfo:eu-repo/semantics/openAccess2012-08-23T18:01:08Zoai:revistas.usp.br:article/40021Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-08-23T18:01:08Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
The effects on mucociliary clearance of prednisone associated with bronchial section |
title |
The effects on mucociliary clearance of prednisone associated with bronchial section |
spellingShingle |
The effects on mucociliary clearance of prednisone associated with bronchial section Braga, Karina Andrighetti de Oliveira Prednisone Mucociliary clearance Bronchi Lung transplantation Immunosuppression |
title_short |
The effects on mucociliary clearance of prednisone associated with bronchial section |
title_full |
The effects on mucociliary clearance of prednisone associated with bronchial section |
title_fullStr |
The effects on mucociliary clearance of prednisone associated with bronchial section |
title_full_unstemmed |
The effects on mucociliary clearance of prednisone associated with bronchial section |
title_sort |
The effects on mucociliary clearance of prednisone associated with bronchial section |
author |
Braga, Karina Andrighetti de Oliveira |
author_facet |
Braga, Karina Andrighetti de Oliveira Nepomuceno, Natalia Aparecida Correia, Aristides Tadeu Jatene, Fabio Biscegli Pêgo-Fernandes, Paulo Manuel |
author_role |
author |
author2 |
Nepomuceno, Natalia Aparecida Correia, Aristides Tadeu Jatene, Fabio Biscegli Pêgo-Fernandes, Paulo Manuel |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Braga, Karina Andrighetti de Oliveira Nepomuceno, Natalia Aparecida Correia, Aristides Tadeu Jatene, Fabio Biscegli Pêgo-Fernandes, Paulo Manuel |
dc.subject.por.fl_str_mv |
Prednisone Mucociliary clearance Bronchi Lung transplantation Immunosuppression |
topic |
Prednisone Mucociliary clearance Bronchi Lung transplantation Immunosuppression |
description |
OBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance. METHODS: A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy: prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated. RESULTS: Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (p |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/40021 10.6061/clinics/2012(06)16 |
url |
https://www.revistas.usp.br/clinics/article/view/40021 |
identifier_str_mv |
10.6061/clinics/2012(06)16 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/40021/42886 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 67 No. 6 (2012); 647-652 Clinics; v. 67 n. 6 (2012); 647-652 Clinics; Vol. 67 Núm. 6 (2012); 647-652 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222758669385728 |