The effects on mucociliary clearance of prednisone associated with bronchial section

Detalhes bibliográficos
Autor(a) principal: Braga, Karina Andrighetti de Oliveira
Data de Publicação: 2012
Outros Autores: Nepomuceno, Natalia Aparecida, Correia, Aristides Tadeu, Jatene, Fabio Biscegli, Pêgo-Fernandes, Paulo Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/40021
Resumo: OBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance. METHODS: A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy: prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated. RESULTS: Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (p
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spelling The effects on mucociliary clearance of prednisone associated with bronchial sectionPrednisoneMucociliary clearanceBronchiLung transplantationImmunosuppressionOBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance. METHODS: A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy: prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated. RESULTS: Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4002110.6061/clinics/2012(06)16Clinics; Vol. 67 No. 6 (2012); 647-652Clinics; v. 67 n. 6 (2012); 647-652Clinics; Vol. 67 Núm. 6 (2012); 647-6521980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/40021/42886Braga, Karina Andrighetti de OliveiraNepomuceno, Natalia AparecidaCorreia, Aristides TadeuJatene, Fabio BiscegliPêgo-Fernandes, Paulo Manuelinfo:eu-repo/semantics/openAccess2012-08-23T18:01:08Zoai:revistas.usp.br:article/40021Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-08-23T18:01:08Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv The effects on mucociliary clearance of prednisone associated with bronchial section
title The effects on mucociliary clearance of prednisone associated with bronchial section
spellingShingle The effects on mucociliary clearance of prednisone associated with bronchial section
Braga, Karina Andrighetti de Oliveira
Prednisone
Mucociliary clearance
Bronchi
Lung transplantation
Immunosuppression
title_short The effects on mucociliary clearance of prednisone associated with bronchial section
title_full The effects on mucociliary clearance of prednisone associated with bronchial section
title_fullStr The effects on mucociliary clearance of prednisone associated with bronchial section
title_full_unstemmed The effects on mucociliary clearance of prednisone associated with bronchial section
title_sort The effects on mucociliary clearance of prednisone associated with bronchial section
author Braga, Karina Andrighetti de Oliveira
author_facet Braga, Karina Andrighetti de Oliveira
Nepomuceno, Natalia Aparecida
Correia, Aristides Tadeu
Jatene, Fabio Biscegli
Pêgo-Fernandes, Paulo Manuel
author_role author
author2 Nepomuceno, Natalia Aparecida
Correia, Aristides Tadeu
Jatene, Fabio Biscegli
Pêgo-Fernandes, Paulo Manuel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Braga, Karina Andrighetti de Oliveira
Nepomuceno, Natalia Aparecida
Correia, Aristides Tadeu
Jatene, Fabio Biscegli
Pêgo-Fernandes, Paulo Manuel
dc.subject.por.fl_str_mv Prednisone
Mucociliary clearance
Bronchi
Lung transplantation
Immunosuppression
topic Prednisone
Mucociliary clearance
Bronchi
Lung transplantation
Immunosuppression
description OBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance. METHODS: A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy: prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated. RESULTS: Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (p
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/40021
10.6061/clinics/2012(06)16
url https://www.revistas.usp.br/clinics/article/view/40021
identifier_str_mv 10.6061/clinics/2012(06)16
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/40021/42886
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 67 No. 6 (2012); 647-652
Clinics; v. 67 n. 6 (2012); 647-652
Clinics; Vol. 67 Núm. 6 (2012); 647-652
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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