Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/17806 |
Resumo: | Critical illness has a major impact on the nutritional status of both children and adults. A retrospective study was conducted to evaluate the incidence of hospital malnutrition at a pediatric tertiary intensive care unit (PICU). Serum concentrations of IL-6 in subgroups of well-nourished and malnourished patients were also evaluated in an attempt to identify those with a potential nutritional risk. METHODS: A total of 1077 patients were enrolled. Nutritional status was evaluated by Z-score (weight for age). We compared mortality, sepsis incidence, and length of hospital stay for nourished and malnourished patients. We had a subgroup of 15 patients with severe malnutrition (MN) and another with 14 well-nourished patients (WN). Cytokine IL-6 determinations were performed by enzyme-linked immunosorbent assay. RESULTS: 53% of patients were classified with moderate or severe malnutrition. Similar amounts of C- reactive protein (CRP) were observed in WN and MN patients. Both groups were able to increase IL-6 concentrations in response to inflammatory systemic response and the levels followed a similar evolution during the study. However, the mean values of serum IL-6 were significantly different between WN and MN patients across time, throughout the study (p = 0.043). DISCUSSION: a considerable proportion of malnourished patients need specialized nutritional therapy during an intensive care unit (ICU) stay. Malnutrition in children remains largely unrecognized by healthcare workers on admission. CONCLUSIONS: The incidence of malnutrition was very high. Malnourished patients maintain the capacity to release inflammatory markers such as CRP and IL-6, which can be considered favorable for combating infections On the other hand, this capacity might also have a significant impact on nutritional status during hospitalization. |
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Clinics |
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Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit Nutritional statusCritical careHospitalizationInterleukinsSepsis Critical illness has a major impact on the nutritional status of both children and adults. A retrospective study was conducted to evaluate the incidence of hospital malnutrition at a pediatric tertiary intensive care unit (PICU). Serum concentrations of IL-6 in subgroups of well-nourished and malnourished patients were also evaluated in an attempt to identify those with a potential nutritional risk. METHODS: A total of 1077 patients were enrolled. Nutritional status was evaluated by Z-score (weight for age). We compared mortality, sepsis incidence, and length of hospital stay for nourished and malnourished patients. We had a subgroup of 15 patients with severe malnutrition (MN) and another with 14 well-nourished patients (WN). Cytokine IL-6 determinations were performed by enzyme-linked immunosorbent assay. RESULTS: 53% of patients were classified with moderate or severe malnutrition. Similar amounts of C- reactive protein (CRP) were observed in WN and MN patients. Both groups were able to increase IL-6 concentrations in response to inflammatory systemic response and the levels followed a similar evolution during the study. However, the mean values of serum IL-6 were significantly different between WN and MN patients across time, throughout the study (p = 0.043). DISCUSSION: a considerable proportion of malnourished patients need specialized nutritional therapy during an intensive care unit (ICU) stay. Malnutrition in children remains largely unrecognized by healthcare workers on admission. CONCLUSIONS: The incidence of malnutrition was very high. Malnourished patients maintain the capacity to release inflammatory markers such as CRP and IL-6, which can be considered favorable for combating infections On the other hand, this capacity might also have a significant impact on nutritional status during hospitalization. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1780610.1590/S1807-59322008000300012Clinics; Vol. 63 No. 3 (2008); 357-362 Clinics; v. 63 n. 3 (2008); 357-362 Clinics; Vol. 63 Núm. 3 (2008); 357-362 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/17806/19871Delgado, Artur F.Okay, Thelma S.Leone, ClaudioNichols, BufordDel Negro, Gilda MariaVaz, Flávio Adolfo Costainfo:eu-repo/semantics/openAccess2012-05-22T18:34:55Zoai:revistas.usp.br:article/17806Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-22T18:34:55Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit |
title |
Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit |
spellingShingle |
Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit Delgado, Artur F. Nutritional status Critical care Hospitalization Interleukins Sepsis |
title_short |
Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit |
title_full |
Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit |
title_fullStr |
Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit |
title_full_unstemmed |
Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit |
title_sort |
Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit |
author |
Delgado, Artur F. |
author_facet |
Delgado, Artur F. Okay, Thelma S. Leone, Claudio Nichols, Buford Del Negro, Gilda Maria Vaz, Flávio Adolfo Costa |
author_role |
author |
author2 |
Okay, Thelma S. Leone, Claudio Nichols, Buford Del Negro, Gilda Maria Vaz, Flávio Adolfo Costa |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Delgado, Artur F. Okay, Thelma S. Leone, Claudio Nichols, Buford Del Negro, Gilda Maria Vaz, Flávio Adolfo Costa |
dc.subject.por.fl_str_mv |
Nutritional status Critical care Hospitalization Interleukins Sepsis |
topic |
Nutritional status Critical care Hospitalization Interleukins Sepsis |
description |
Critical illness has a major impact on the nutritional status of both children and adults. A retrospective study was conducted to evaluate the incidence of hospital malnutrition at a pediatric tertiary intensive care unit (PICU). Serum concentrations of IL-6 in subgroups of well-nourished and malnourished patients were also evaluated in an attempt to identify those with a potential nutritional risk. METHODS: A total of 1077 patients were enrolled. Nutritional status was evaluated by Z-score (weight for age). We compared mortality, sepsis incidence, and length of hospital stay for nourished and malnourished patients. We had a subgroup of 15 patients with severe malnutrition (MN) and another with 14 well-nourished patients (WN). Cytokine IL-6 determinations were performed by enzyme-linked immunosorbent assay. RESULTS: 53% of patients were classified with moderate or severe malnutrition. Similar amounts of C- reactive protein (CRP) were observed in WN and MN patients. Both groups were able to increase IL-6 concentrations in response to inflammatory systemic response and the levels followed a similar evolution during the study. However, the mean values of serum IL-6 were significantly different between WN and MN patients across time, throughout the study (p = 0.043). DISCUSSION: a considerable proportion of malnourished patients need specialized nutritional therapy during an intensive care unit (ICU) stay. Malnutrition in children remains largely unrecognized by healthcare workers on admission. CONCLUSIONS: The incidence of malnutrition was very high. Malnourished patients maintain the capacity to release inflammatory markers such as CRP and IL-6, which can be considered favorable for combating infections On the other hand, this capacity might also have a significant impact on nutritional status during hospitalization. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17806 10.1590/S1807-59322008000300012 |
url |
https://www.revistas.usp.br/clinics/article/view/17806 |
identifier_str_mv |
10.1590/S1807-59322008000300012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/17806/19871 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 63 No. 3 (2008); 357-362 Clinics; v. 63 n. 3 (2008); 357-362 Clinics; Vol. 63 Núm. 3 (2008); 357-362 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222753901510656 |