Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Bruno
Data de Publicação: 2011
Outros Autores: Figueroa, Diego Mendrot Taboas, Fang, Jiao, Rosa, Kaleizu Teodoro, Llesuy, Suzana, De Angelis, Kátia, Irigoyen, Maria Cláudia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19272
Resumo: OBJECTIVES: To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction. INTRODUCTION: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. METHODS: Male Wistar rats were divided into four groups: control-sham, diabetes-sham, myocardial infarction, and diabetes + myocardial infarction. Myocardial infarction was induced 14 days after diabetes induction. Ventricular function and morphometry, as well as oxidative stress and hemodynamic parameters, were evaluated after seven days of myocardial infarction. RESULTS: The myocardial infarction area, which was similar in the infarcted groups at the initial evaluation, was reduced in the diabetes + myocardial infarction animals (23 ± 3%) when compared with the myocardial infarction (42 ± 7%, p
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spelling Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents DiabetesMyocardial InfarctionVentricular FunctionOxidative StressMortality Rate OBJECTIVES: To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction. INTRODUCTION: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. METHODS: Male Wistar rats were divided into four groups: control-sham, diabetes-sham, myocardial infarction, and diabetes + myocardial infarction. Myocardial infarction was induced 14 days after diabetes induction. Ventricular function and morphometry, as well as oxidative stress and hemodynamic parameters, were evaluated after seven days of myocardial infarction. RESULTS: The myocardial infarction area, which was similar in the infarcted groups at the initial evaluation, was reduced in the diabetes + myocardial infarction animals (23 ± 3%) when compared with the myocardial infarction (42 ± 7%, pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1927210.1590/S1807-59322011000800022Clinics; Vol. 66 No. 8 (2011); 1437-1442 Clinics; v. 66 n. 8 (2011); 1437-1442 Clinics; Vol. 66 Núm. 8 (2011); 1437-1442 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19272/21335Rodrigues, BrunoFigueroa, Diego Mendrot TaboasFang, JiaoRosa, Kaleizu TeodoroLlesuy, SuzanaDe Angelis, KátiaIrigoyen, Maria Cláudiainfo:eu-repo/semantics/openAccess2012-05-23T16:31:25Zoai:revistas.usp.br:article/19272Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:31:25Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
spellingShingle Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
Rodrigues, Bruno
Diabetes
Myocardial Infarction
Ventricular Function
Oxidative Stress
Mortality Rate
title_short Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title_full Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title_fullStr Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title_full_unstemmed Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title_sort Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
author Rodrigues, Bruno
author_facet Rodrigues, Bruno
Figueroa, Diego Mendrot Taboas
Fang, Jiao
Rosa, Kaleizu Teodoro
Llesuy, Suzana
De Angelis, Kátia
Irigoyen, Maria Cláudia
author_role author
author2 Figueroa, Diego Mendrot Taboas
Fang, Jiao
Rosa, Kaleizu Teodoro
Llesuy, Suzana
De Angelis, Kátia
Irigoyen, Maria Cláudia
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Bruno
Figueroa, Diego Mendrot Taboas
Fang, Jiao
Rosa, Kaleizu Teodoro
Llesuy, Suzana
De Angelis, Kátia
Irigoyen, Maria Cláudia
dc.subject.por.fl_str_mv Diabetes
Myocardial Infarction
Ventricular Function
Oxidative Stress
Mortality Rate
topic Diabetes
Myocardial Infarction
Ventricular Function
Oxidative Stress
Mortality Rate
description OBJECTIVES: To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction. INTRODUCTION: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. METHODS: Male Wistar rats were divided into four groups: control-sham, diabetes-sham, myocardial infarction, and diabetes + myocardial infarction. Myocardial infarction was induced 14 days after diabetes induction. Ventricular function and morphometry, as well as oxidative stress and hemodynamic parameters, were evaluated after seven days of myocardial infarction. RESULTS: The myocardial infarction area, which was similar in the infarcted groups at the initial evaluation, was reduced in the diabetes + myocardial infarction animals (23 ± 3%) when compared with the myocardial infarction (42 ± 7%, p
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19272
10.1590/S1807-59322011000800022
url https://www.revistas.usp.br/clinics/article/view/19272
identifier_str_mv 10.1590/S1807-59322011000800022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19272/21335
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 8 (2011); 1437-1442
Clinics; v. 66 n. 8 (2011); 1437-1442
Clinics; Vol. 66 Núm. 8 (2011); 1437-1442
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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