The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease

Detalhes bibliográficos
Autor(a) principal: Vasconcelos, Luciano de Gois
Data de Publicação: 2014
Outros Autores: Jackowski, Andrea Parolin, Oliveira, Maira Okada de, Flor, Yona Mayara Ribeiro, Souza, Altay Alves Lino, Bueno, Orlando Francisco Amodeo, Brucki, Sonia Maria Dozzi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/77065
Resumo: OBJECTIVE: To establish whether alterations of brain structures in Alzheimer's disease are associated with executive dysfunction. METHODS: Nineteen patients with Alzheimer's disease and 22 older control subjects underwent a comprehensive evaluation. The clock drawing test, digit span test, executive motor function test, Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test), and Stroop test were used to evaluate executive dysfunction. A multiparametric approach using the FreeSurfer image analysis suite provided a description of volumetric and geometric features of the gray matter structures. RESULTS: The cortical thickness maps showed a negative correlation between the Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test) and the right middle frontal gyrus; a positive correlation between the executive motor function test and the left superior parietal gyrus, left middle temporal gyrus, bilateral supramarginal gyri, right middle frontal gyrus, and right precuneus; a negative correlation between the Stroop test (part III) and the right superior parietal gyrus; and a negative correlation between the Stroop test (part III) and the right middle temporal gyrus. CONCLUSION: Executive dysfunction in Alzheimer's disease is correlated with alterations not only in the frontal areas but also within many temporal and parietal regions.
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spelling The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's diseaseOBJECTIVE: To establish whether alterations of brain structures in Alzheimer's disease are associated with executive dysfunction. METHODS: Nineteen patients with Alzheimer's disease and 22 older control subjects underwent a comprehensive evaluation. The clock drawing test, digit span test, executive motor function test, Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test), and Stroop test were used to evaluate executive dysfunction. A multiparametric approach using the FreeSurfer image analysis suite provided a description of volumetric and geometric features of the gray matter structures. RESULTS: The cortical thickness maps showed a negative correlation between the Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test) and the right middle frontal gyrus; a positive correlation between the executive motor function test and the left superior parietal gyrus, left middle temporal gyrus, bilateral supramarginal gyri, right middle frontal gyrus, and right precuneus; a negative correlation between the Stroop test (part III) and the right superior parietal gyrus; and a negative correlation between the Stroop test (part III) and the right middle temporal gyrus. CONCLUSION: Executive dysfunction in Alzheimer's disease is correlated with alterations not only in the frontal areas but also within many temporal and parietal regions.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/7706510.1590/clin.v69i1.77065Clinics; Vol. 69 No. 1 (2014); 28-37Clinics; v. 69 n. 1 (2014); 28-37Clinics; Vol. 69 Núm. 1 (2014); 28-371980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/77065/80930Vasconcelos, Luciano de GoisJackowski, Andrea ParolinOliveira, Maira Okada deFlor, Yona Mayara RibeiroSouza, Altay Alves LinoBueno, Orlando Francisco AmodeoBrucki, Sonia Maria Dozziinfo:eu-repo/semantics/openAccess2014-03-24T12:25:14Zoai:revistas.usp.br:article/77065Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2014-03-24T12:25:14Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
title The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
spellingShingle The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
Vasconcelos, Luciano de Gois
title_short The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
title_full The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
title_fullStr The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
title_full_unstemmed The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
title_sort The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease
author Vasconcelos, Luciano de Gois
author_facet Vasconcelos, Luciano de Gois
Jackowski, Andrea Parolin
Oliveira, Maira Okada de
Flor, Yona Mayara Ribeiro
Souza, Altay Alves Lino
Bueno, Orlando Francisco Amodeo
Brucki, Sonia Maria Dozzi
author_role author
author2 Jackowski, Andrea Parolin
Oliveira, Maira Okada de
Flor, Yona Mayara Ribeiro
Souza, Altay Alves Lino
Bueno, Orlando Francisco Amodeo
Brucki, Sonia Maria Dozzi
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vasconcelos, Luciano de Gois
Jackowski, Andrea Parolin
Oliveira, Maira Okada de
Flor, Yona Mayara Ribeiro
Souza, Altay Alves Lino
Bueno, Orlando Francisco Amodeo
Brucki, Sonia Maria Dozzi
description OBJECTIVE: To establish whether alterations of brain structures in Alzheimer's disease are associated with executive dysfunction. METHODS: Nineteen patients with Alzheimer's disease and 22 older control subjects underwent a comprehensive evaluation. The clock drawing test, digit span test, executive motor function test, Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test), and Stroop test were used to evaluate executive dysfunction. A multiparametric approach using the FreeSurfer image analysis suite provided a description of volumetric and geometric features of the gray matter structures. RESULTS: The cortical thickness maps showed a negative correlation between the Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test) and the right middle frontal gyrus; a positive correlation between the executive motor function test and the left superior parietal gyrus, left middle temporal gyrus, bilateral supramarginal gyri, right middle frontal gyrus, and right precuneus; a negative correlation between the Stroop test (part III) and the right superior parietal gyrus; and a negative correlation between the Stroop test (part III) and the right middle temporal gyrus. CONCLUSION: Executive dysfunction in Alzheimer's disease is correlated with alterations not only in the frontal areas but also within many temporal and parietal regions.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/77065
10.1590/clin.v69i1.77065
url https://www.revistas.usp.br/clinics/article/view/77065
identifier_str_mv 10.1590/clin.v69i1.77065
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/77065/80930
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 69 No. 1 (2014); 28-37
Clinics; v. 69 n. 1 (2014); 28-37
Clinics; Vol. 69 Núm. 1 (2014); 28-37
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
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institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
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