Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/212609 |
Resumo: | OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies’ ability to neutralize the virus and confer long-term immunity. Nevertheless, the response can also be associated with disease severity and evolution. This study correlated the clinical characteristics of convalescent COVID-19 patients with immunoglobulin A (IgA) and IgG anti-SARS-CoV-2 antibodies. METHODS: This study included 51 COVID-19 health care professionals who were candidates for convalescent plasma donation from April to June 2020. The subjects had symptomatic COVID-19 with a polymerase chain reaction-confirmed diagnosis. We measured anti-SARS-CoV-2 IgA and IgG antibodies after symptom recovery, and the subjects were classified as having mild, moderate, or severe symptoms. RESULTS: Anti-SARS-CoV-2 antibodies were positive in most patients (90.2%). The antibody indexes for IgA and IgG did not differ significantly between patients presenting with mild or moderate symptoms. However, they were significantly higher in patients with severe symptoms. CONCLUSIONS: Our study showed an association between higher antibody indexes and severe COVID-19 cases, and several hypotheses regarding the association of the antibody dynamics and severity of the disease in SARS-CoV-2 infection have been raised, although many questions remain unanswered. |
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oai:revistas.usp.br:article/212609 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
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Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questionsSARS-CoV-2COVID-19AntibodiesDisease SeverityOBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies’ ability to neutralize the virus and confer long-term immunity. Nevertheless, the response can also be associated with disease severity and evolution. This study correlated the clinical characteristics of convalescent COVID-19 patients with immunoglobulin A (IgA) and IgG anti-SARS-CoV-2 antibodies. METHODS: This study included 51 COVID-19 health care professionals who were candidates for convalescent plasma donation from April to June 2020. The subjects had symptomatic COVID-19 with a polymerase chain reaction-confirmed diagnosis. We measured anti-SARS-CoV-2 IgA and IgG antibodies after symptom recovery, and the subjects were classified as having mild, moderate, or severe symptoms. RESULTS: Anti-SARS-CoV-2 antibodies were positive in most patients (90.2%). The antibody indexes for IgA and IgG did not differ significantly between patients presenting with mild or moderate symptoms. However, they were significantly higher in patients with severe symptoms. CONCLUSIONS: Our study showed an association between higher antibody indexes and severe COVID-19 cases, and several hypotheses regarding the association of the antibody dynamics and severity of the disease in SARS-CoV-2 infection have been raised, although many questions remain unanswered.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2021-08-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21260910.6061/clinics/2021/e2818Clinics; Vol. 76 (2021); e2818Clinics; v. 76 (2021); e2818Clinics; Vol. 76 (2021); e28181980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/212609/194606Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessCubo, EditoraBonetti, Tatiana Carvalho de SouzaLatini, Flavia Roche MoreiraInvitti, Adriana LukowFonseca, Marcelo Cunio MachadoScorza, Fulvio AlexandreSaldanha, Maira GarciaBellucco, Fernanda T.Bacarov, Natalia B.S.Soane, Michel M.Girão, Manoel João Batista Castelo2023-07-06T13:04:04Zoai:revistas.usp.br:article/212609Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:04Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
title |
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
spellingShingle |
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions Cubo, Editora SARS-CoV-2 COVID-19 Antibodies Disease Severity |
title_short |
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
title_full |
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
title_fullStr |
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
title_full_unstemmed |
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
title_sort |
Antibody indexes in COVID-19 convalescent plasma donors: Unanswered questions |
author |
Cubo, Editora |
author_facet |
Cubo, Editora Bonetti, Tatiana Carvalho de Souza Latini, Flavia Roche Moreira Invitti, Adriana Lukow Fonseca, Marcelo Cunio Machado Scorza, Fulvio Alexandre Saldanha, Maira Garcia Bellucco, Fernanda T. Bacarov, Natalia B.S. Soane, Michel M. Girão, Manoel João Batista Castelo |
author_role |
author |
author2 |
Bonetti, Tatiana Carvalho de Souza Latini, Flavia Roche Moreira Invitti, Adriana Lukow Fonseca, Marcelo Cunio Machado Scorza, Fulvio Alexandre Saldanha, Maira Garcia Bellucco, Fernanda T. Bacarov, Natalia B.S. Soane, Michel M. Girão, Manoel João Batista Castelo |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cubo, Editora Bonetti, Tatiana Carvalho de Souza Latini, Flavia Roche Moreira Invitti, Adriana Lukow Fonseca, Marcelo Cunio Machado Scorza, Fulvio Alexandre Saldanha, Maira Garcia Bellucco, Fernanda T. Bacarov, Natalia B.S. Soane, Michel M. Girão, Manoel João Batista Castelo |
dc.subject.por.fl_str_mv |
SARS-CoV-2 COVID-19 Antibodies Disease Severity |
topic |
SARS-CoV-2 COVID-19 Antibodies Disease Severity |
description |
OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized by high contagiousness, as well as variable clinical manifestations and immune responses. The antibody response to SARS-CoV-2 is directly related to viral clearance and the antibodies’ ability to neutralize the virus and confer long-term immunity. Nevertheless, the response can also be associated with disease severity and evolution. This study correlated the clinical characteristics of convalescent COVID-19 patients with immunoglobulin A (IgA) and IgG anti-SARS-CoV-2 antibodies. METHODS: This study included 51 COVID-19 health care professionals who were candidates for convalescent plasma donation from April to June 2020. The subjects had symptomatic COVID-19 with a polymerase chain reaction-confirmed diagnosis. We measured anti-SARS-CoV-2 IgA and IgG antibodies after symptom recovery, and the subjects were classified as having mild, moderate, or severe symptoms. RESULTS: Anti-SARS-CoV-2 antibodies were positive in most patients (90.2%). The antibody indexes for IgA and IgG did not differ significantly between patients presenting with mild or moderate symptoms. However, they were significantly higher in patients with severe symptoms. CONCLUSIONS: Our study showed an association between higher antibody indexes and severe COVID-19 cases, and several hypotheses regarding the association of the antibody dynamics and severity of the disease in SARS-CoV-2 infection have been raised, although many questions remain unanswered. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/212609 10.6061/clinics/2021/e2818 |
url |
https://www.revistas.usp.br/clinics/article/view/212609 |
identifier_str_mv |
10.6061/clinics/2021/e2818 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/212609/194606 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 76 (2021); e2818 Clinics; v. 76 (2021); e2818 Clinics; Vol. 76 (2021); e2818 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222766060797952 |