Residual C-peptide in patients with Type 1 diabetes and multiethnic backgrounds

• Autor(a) principal: Almeida, Mirella Hansen de
• Data de Publicação: 2013
• Outros Autores: Dantas, Joana Rodrigues, Barone, Bianca, Serfaty, Fabiano Marcel, Kupfer, Rosane, Albernaz, Marta, Bencke, Maria Rocio, Zajdenverg, Lenita, Rodacki, Melanie, Oliveira, José Egídio Paulo de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Clinics
• Texto Completo: https://www.revistas.usp.br/clinics/article/view/52330
• topic: Diabetes Mellitus Type-1; C-Peptide; Insulin Secretion; Disease Duration; GADA; Autoimmune Disease

OBJECTIVE: To evaluate serum C-peptide in 88 patients from a multiethnic population with Type-1 diabetes and variable disease durations. METHOD: Eighty-eight patients with a mean disease duration of 8.1 +7.6 years were included and underwent C-peptide measurement before and after glucagon stimulation. Chi-squared and Mann Whitney U-tests were used to compare the variables between groups (all two-tailed, a = 0.05). Spearmans correlation coefficient was used to test the association between the continuous variables. Logistic regression was used for the multivariate analysis. Twenty-eight (31.8%) individuals had significantly detectable C-peptide levels after stimuli, particularly those with a shorter disease duration (p