Evaluation of renal function and immune system cells in elderly individuals from São Paulo City
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/52314 |
Resumo: | OBJECTIVES: Both renal function and immune system function decline with age. Although controversial, a significant number of studies have shown that the decline in kidney function is associated with the worsening of the immune system. These findings are reinforced by the increased susceptibility to infections and deficient immunization coverage after vaccination both in patients with chronic renal disease and in elderly individuals. Our objective was to evaluate a non-institutionalized elderly population from São Paulo City and correlate the estimated glomerular filtration rate with the percentage of lymphocytes in circulation. METHODS: A random population of 237 individuals (107 men and 130 women), ranging in age from 60 to 101 years, who were enrolled in the Health, Well-Being and Aging Study was evaluated for renal function (Modification on Diet in Renal Disease formula) and lymphocyte percentage (flow cytometry). RESULTS: Aging was associated with a decrease in the estimated glomerular filtration rate in both male and female individuals. We did not identify a significant correlation between the estimated glomerular filtration rate and either the percentage of CD4, CD8, and B cells or CD4/CD8 ratio. The median percentage of CD8+ T cells was significantly lower in individuals with an estimated glomerular filtration rate >;60 mL/min/1.73 m². CONCLUSIONS: In this study, no statistical correlation was found between the estimated glomerular filtration rate and either the lymphocyte phenotype (CD4+,CD8+, and CD19+ cells) or the CD4/CD8 ratio in blood. |
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Evaluation of renal function and immune system cells in elderly individuals from São Paulo City Renal FunctionElderlyImmune SystemFlow Cytometry OBJECTIVES: Both renal function and immune system function decline with age. Although controversial, a significant number of studies have shown that the decline in kidney function is associated with the worsening of the immune system. These findings are reinforced by the increased susceptibility to infections and deficient immunization coverage after vaccination both in patients with chronic renal disease and in elderly individuals. Our objective was to evaluate a non-institutionalized elderly population from São Paulo City and correlate the estimated glomerular filtration rate with the percentage of lymphocytes in circulation. METHODS: A random population of 237 individuals (107 men and 130 women), ranging in age from 60 to 101 years, who were enrolled in the Health, Well-Being and Aging Study was evaluated for renal function (Modification on Diet in Renal Disease formula) and lymphocyte percentage (flow cytometry). RESULTS: Aging was associated with a decrease in the estimated glomerular filtration rate in both male and female individuals. We did not identify a significant correlation between the estimated glomerular filtration rate and either the percentage of CD4, CD8, and B cells or CD4/CD8 ratio. The median percentage of CD8+ T cells was significantly lower in individuals with an estimated glomerular filtration rate >;60 mL/min/1.73 m². CONCLUSIONS: In this study, no statistical correlation was found between the estimated glomerular filtration rate and either the lymphocyte phenotype (CD4+,CD8+, and CD19+ cells) or the CD4/CD8 ratio in blood. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/5231410.6061/clinics/2013(01)OA06Clinics; Vol. 68 No. 1 (2013); 39-44 Clinics; v. 68 n. 1 (2013); 39-44 Clinics; Vol. 68 Núm. 1 (2013); 39-44 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/52314/56341Teixeira, DanielaLongo-Maugeri, leda MariaDuarte, Yeda Aparecida OliveiraLebrão, Maria LuciaBueno, Valquiriainfo:eu-repo/semantics/openAccess2013-03-09T14:08:18Zoai:revistas.usp.br:article/52314Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2013-03-09T14:08:18Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Evaluation of renal function and immune system cells in elderly individuals from São Paulo City |
title |
Evaluation of renal function and immune system cells in elderly individuals from São Paulo City |
spellingShingle |
Evaluation of renal function and immune system cells in elderly individuals from São Paulo City Teixeira, Daniela Renal Function Elderly Immune System Flow Cytometry |
title_short |
Evaluation of renal function and immune system cells in elderly individuals from São Paulo City |
title_full |
Evaluation of renal function and immune system cells in elderly individuals from São Paulo City |
title_fullStr |
Evaluation of renal function and immune system cells in elderly individuals from São Paulo City |
title_full_unstemmed |
Evaluation of renal function and immune system cells in elderly individuals from São Paulo City |
title_sort |
Evaluation of renal function and immune system cells in elderly individuals from São Paulo City |
author |
Teixeira, Daniela |
author_facet |
Teixeira, Daniela Longo-Maugeri, leda Maria Duarte, Yeda Aparecida Oliveira Lebrão, Maria Lucia Bueno, Valquiria |
author_role |
author |
author2 |
Longo-Maugeri, leda Maria Duarte, Yeda Aparecida Oliveira Lebrão, Maria Lucia Bueno, Valquiria |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Daniela Longo-Maugeri, leda Maria Duarte, Yeda Aparecida Oliveira Lebrão, Maria Lucia Bueno, Valquiria |
dc.subject.por.fl_str_mv |
Renal Function Elderly Immune System Flow Cytometry |
topic |
Renal Function Elderly Immune System Flow Cytometry |
description |
OBJECTIVES: Both renal function and immune system function decline with age. Although controversial, a significant number of studies have shown that the decline in kidney function is associated with the worsening of the immune system. These findings are reinforced by the increased susceptibility to infections and deficient immunization coverage after vaccination both in patients with chronic renal disease and in elderly individuals. Our objective was to evaluate a non-institutionalized elderly population from São Paulo City and correlate the estimated glomerular filtration rate with the percentage of lymphocytes in circulation. METHODS: A random population of 237 individuals (107 men and 130 women), ranging in age from 60 to 101 years, who were enrolled in the Health, Well-Being and Aging Study was evaluated for renal function (Modification on Diet in Renal Disease formula) and lymphocyte percentage (flow cytometry). RESULTS: Aging was associated with a decrease in the estimated glomerular filtration rate in both male and female individuals. We did not identify a significant correlation between the estimated glomerular filtration rate and either the percentage of CD4, CD8, and B cells or CD4/CD8 ratio. The median percentage of CD8+ T cells was significantly lower in individuals with an estimated glomerular filtration rate >;60 mL/min/1.73 m². CONCLUSIONS: In this study, no statistical correlation was found between the estimated glomerular filtration rate and either the lymphocyte phenotype (CD4+,CD8+, and CD19+ cells) or the CD4/CD8 ratio in blood. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/52314 10.6061/clinics/2013(01)OA06 |
url |
https://www.revistas.usp.br/clinics/article/view/52314 |
identifier_str_mv |
10.6061/clinics/2013(01)OA06 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/52314/56341 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 68 No. 1 (2013); 39-44 Clinics; v. 68 n. 1 (2013); 39-44 Clinics; Vol. 68 Núm. 1 (2013); 39-44 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222759684407296 |