Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/45864 |
Resumo: | OBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied. METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy. RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain. CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil. |
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Prevalence of celiac disease among blood donors in São Paulo: the most populated city in BrazilCeliac diseasePrevalenceBlood centerAnti-transglutaminase antibodyAnti-endomysium antibodyHuman leukocyte antigenOBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied. METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy. RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain. CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4586410.6061/clinics/2012(09)05Clinics; Vol. 67 No. 9 (2012); 1013-1018Clinics; v. 67 n. 9 (2012); 1013-1018Clinics; Vol. 67 Núm. 9 (2012); 1013-10181980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/45864/49467Alencar, Marília LageOrtiz-Agostinho, Carmen LuciaNishitokukado, lêdaDamião, Adérson O.M.C.Abrantes-Lemos, Clarice P.Leite, André Zonetti de ArrudaBrito, Thales deChamone, Dalton de Alencar FischerSilva, Maria Elizabeth Rossi daGiannella-Neto, DanielSipahi, Aytan Mirandainfo:eu-repo/semantics/openAccess2012-10-10T20:41:58Zoai:revistas.usp.br:article/45864Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-10-10T20:41:58Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil |
title |
Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil |
spellingShingle |
Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil Alencar, Marília Lage Celiac disease Prevalence Blood center Anti-transglutaminase antibody Anti-endomysium antibody Human leukocyte antigen |
title_short |
Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil |
title_full |
Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil |
title_fullStr |
Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil |
title_full_unstemmed |
Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil |
title_sort |
Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil |
author |
Alencar, Marília Lage |
author_facet |
Alencar, Marília Lage Ortiz-Agostinho, Carmen Lucia Nishitokukado, lêda Damião, Adérson O.M.C. Abrantes-Lemos, Clarice P. Leite, André Zonetti de Arruda Brito, Thales de Chamone, Dalton de Alencar Fischer Silva, Maria Elizabeth Rossi da Giannella-Neto, Daniel Sipahi, Aytan Miranda |
author_role |
author |
author2 |
Ortiz-Agostinho, Carmen Lucia Nishitokukado, lêda Damião, Adérson O.M.C. Abrantes-Lemos, Clarice P. Leite, André Zonetti de Arruda Brito, Thales de Chamone, Dalton de Alencar Fischer Silva, Maria Elizabeth Rossi da Giannella-Neto, Daniel Sipahi, Aytan Miranda |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Alencar, Marília Lage Ortiz-Agostinho, Carmen Lucia Nishitokukado, lêda Damião, Adérson O.M.C. Abrantes-Lemos, Clarice P. Leite, André Zonetti de Arruda Brito, Thales de Chamone, Dalton de Alencar Fischer Silva, Maria Elizabeth Rossi da Giannella-Neto, Daniel Sipahi, Aytan Miranda |
dc.subject.por.fl_str_mv |
Celiac disease Prevalence Blood center Anti-transglutaminase antibody Anti-endomysium antibody Human leukocyte antigen |
topic |
Celiac disease Prevalence Blood center Anti-transglutaminase antibody Anti-endomysium antibody Human leukocyte antigen |
description |
OBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied. METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy. RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain. CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/45864 10.6061/clinics/2012(09)05 |
url |
https://www.revistas.usp.br/clinics/article/view/45864 |
identifier_str_mv |
10.6061/clinics/2012(09)05 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/45864/49467 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 67 No. 9 (2012); 1013-1018 Clinics; v. 67 n. 9 (2012); 1013-1018 Clinics; Vol. 67 Núm. 9 (2012); 1013-1018 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222759123419136 |