Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil

Detalhes bibliográficos
Autor(a) principal: Alencar, Marília Lage
Data de Publicação: 2012
Outros Autores: Ortiz-Agostinho, Carmen Lucia, Nishitokukado, lêda, Damião, Adérson O.M.C., Abrantes-Lemos, Clarice P., Leite, André Zonetti de Arruda, Brito, Thales de, Chamone, Dalton de Alencar Fischer, Silva, Maria Elizabeth Rossi da, Giannella-Neto, Daniel, Sipahi, Aytan Miranda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/45864
Resumo: OBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied. METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy. RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain. CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil.
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spelling Prevalence of celiac disease among blood donors in São Paulo: the most populated city in BrazilCeliac diseasePrevalenceBlood centerAnti-transglutaminase antibodyAnti-endomysium antibodyHuman leukocyte antigenOBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied. METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy. RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain. CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4586410.6061/clinics/2012(09)05Clinics; Vol. 67 No. 9 (2012); 1013-1018Clinics; v. 67 n. 9 (2012); 1013-1018Clinics; Vol. 67 Núm. 9 (2012); 1013-10181980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/45864/49467Alencar, Marília LageOrtiz-Agostinho, Carmen LuciaNishitokukado, lêdaDamião, Adérson O.M.C.Abrantes-Lemos, Clarice P.Leite, André Zonetti de ArrudaBrito, Thales deChamone, Dalton de Alencar FischerSilva, Maria Elizabeth Rossi daGiannella-Neto, DanielSipahi, Aytan Mirandainfo:eu-repo/semantics/openAccess2012-10-10T20:41:58Zoai:revistas.usp.br:article/45864Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-10-10T20:41:58Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
title Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
spellingShingle Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
Alencar, Marília Lage
Celiac disease
Prevalence
Blood center
Anti-transglutaminase antibody
Anti-endomysium antibody
Human leukocyte antigen
title_short Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
title_full Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
title_fullStr Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
title_full_unstemmed Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
title_sort Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
author Alencar, Marília Lage
author_facet Alencar, Marília Lage
Ortiz-Agostinho, Carmen Lucia
Nishitokukado, lêda
Damião, Adérson O.M.C.
Abrantes-Lemos, Clarice P.
Leite, André Zonetti de Arruda
Brito, Thales de
Chamone, Dalton de Alencar Fischer
Silva, Maria Elizabeth Rossi da
Giannella-Neto, Daniel
Sipahi, Aytan Miranda
author_role author
author2 Ortiz-Agostinho, Carmen Lucia
Nishitokukado, lêda
Damião, Adérson O.M.C.
Abrantes-Lemos, Clarice P.
Leite, André Zonetti de Arruda
Brito, Thales de
Chamone, Dalton de Alencar Fischer
Silva, Maria Elizabeth Rossi da
Giannella-Neto, Daniel
Sipahi, Aytan Miranda
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alencar, Marília Lage
Ortiz-Agostinho, Carmen Lucia
Nishitokukado, lêda
Damião, Adérson O.M.C.
Abrantes-Lemos, Clarice P.
Leite, André Zonetti de Arruda
Brito, Thales de
Chamone, Dalton de Alencar Fischer
Silva, Maria Elizabeth Rossi da
Giannella-Neto, Daniel
Sipahi, Aytan Miranda
dc.subject.por.fl_str_mv Celiac disease
Prevalence
Blood center
Anti-transglutaminase antibody
Anti-endomysium antibody
Human leukocyte antigen
topic Celiac disease
Prevalence
Blood center
Anti-transglutaminase antibody
Anti-endomysium antibody
Human leukocyte antigen
description OBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immunemediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied. METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy. RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain. CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil.
publishDate 2012
dc.date.none.fl_str_mv 2012-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/45864
10.6061/clinics/2012(09)05
url https://www.revistas.usp.br/clinics/article/view/45864
identifier_str_mv 10.6061/clinics/2012(09)05
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/45864/49467
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 67 No. 9 (2012); 1013-1018
Clinics; v. 67 n. 9 (2012); 1013-1018
Clinics; Vol. 67 Núm. 9 (2012); 1013-1018
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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