The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze

Detalhes bibliográficos
Autor(a) principal: Hosseini, Mahmoud
Data de Publicação: 2010
Outros Autores: Headari, Raheleh, Oryan, Sharbanoo, Hadjzadeh, Mosa Alreza, Saffarzadeh, Fatima, Khazaei, Majid
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/18563
Resumo: OBJECTIVE: The present study was carried out to evaluate the effect of L-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats. METHODS: Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of L-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups. RESULTS: Time latency and path length in the OVX group were significantly higher than in the sham group (P
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spelling The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze EstradiolL-arginineMorris water mazeOvariectomy OBJECTIVE: The present study was carried out to evaluate the effect of L-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats. METHODS: Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of L-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups. RESULTS: Time latency and path length in the OVX group were significantly higher than in the sham group (PHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1856310.1590/S1807-59322010000800011Clinics; Vol. 65 No. 8 (2010); 803-807 Clinics; v. 65 n. 8 (2010); 803-807 Clinics; Vol. 65 Núm. 8 (2010); 803-807 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18563/20626Hosseini, MahmoudHeadari, RahelehOryan, SharbanooHadjzadeh, Mosa AlrezaSaffarzadeh, FatimaKhazaei, Majidinfo:eu-repo/semantics/openAccess2012-05-23T11:33:28Zoai:revistas.usp.br:article/18563Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:33:28Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
title The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
spellingShingle The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
Hosseini, Mahmoud
Estradiol
L-arginine
Morris water maze
Ovariectomy
title_short The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
title_full The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
title_fullStr The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
title_full_unstemmed The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
title_sort The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
author Hosseini, Mahmoud
author_facet Hosseini, Mahmoud
Headari, Raheleh
Oryan, Sharbanoo
Hadjzadeh, Mosa Alreza
Saffarzadeh, Fatima
Khazaei, Majid
author_role author
author2 Headari, Raheleh
Oryan, Sharbanoo
Hadjzadeh, Mosa Alreza
Saffarzadeh, Fatima
Khazaei, Majid
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Hosseini, Mahmoud
Headari, Raheleh
Oryan, Sharbanoo
Hadjzadeh, Mosa Alreza
Saffarzadeh, Fatima
Khazaei, Majid
dc.subject.por.fl_str_mv Estradiol
L-arginine
Morris water maze
Ovariectomy
topic Estradiol
L-arginine
Morris water maze
Ovariectomy
description OBJECTIVE: The present study was carried out to evaluate the effect of L-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats. METHODS: Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of L-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups. RESULTS: Time latency and path length in the OVX group were significantly higher than in the sham group (P
publishDate 2010
dc.date.none.fl_str_mv 2010-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18563
10.1590/S1807-59322010000800011
url https://www.revistas.usp.br/clinics/article/view/18563
identifier_str_mv 10.1590/S1807-59322010000800011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18563/20626
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 65 No. 8 (2010); 803-807
Clinics; v. 65 n. 8 (2010); 803-807
Clinics; Vol. 65 Núm. 8 (2010); 803-807
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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