Differences between the real and the desired worlds in the results of clinical trials

Detalhes bibliográficos
Autor(a) principal: Dib, Regina El
Data de Publicação: 2015
Outros Autores: Jorge, Eliane Chaves, Kamegasawa, Amélia, Daher, Solange Ramires, Spagnuolo, Regina Stella, Silva, Marise Pereira da, Braga, Gabriel Pereira, Volpato, Enilze, Módolo, Norma Sueli Pinheiro, Betini, Marluci, Valle, Adriana do, Corrêa, Ione, Bazan, Rodrigo, Almeida, Ricardo Augusto MB, Weber, Silke Anna Theresa, Molina, Silvana, Yoo, Hugo, Boas, Paulo Villas, Corrente, José Eduardo, Mathew, Joseph, Kapoor, Anil, Carvalho, Raíssa Pierri, Vital, Roberto Bezerra, Braz, Leandro Gobbo, Nascimento Junior, Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/103927
Resumo: OBJECTIVE:We refer to the effectiveness (known as pragmatic or real world) and efficacy (known as explanatory or desired or ideal world) of interventions. However, these terms seem to be randomly chosen by investigators who design clinical trials and do not always reflect the true purpose of the study. A pragmatic-explanatory continuum indicator summary tool was thus developed with the aim of identifying the characteristics of clinical trials that distinguish between effectiveness and efficacy issues. We verified whether clinical trials used the criteria proposed by the indicator summary tool, and we categorized these clinical trials according to a new classification.METHOD:A systematic survey of randomized clinical trials was performed. We added a score ranging from 0 (more efficacious) to 10 (more effective) to each domain of the indicator summary tool and proposed the following classifications: high efficacy (
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spelling Differences between the real and the desired worlds in the results of clinical trials OBJECTIVE:We refer to the effectiveness (known as pragmatic or real world) and efficacy (known as explanatory or desired or ideal world) of interventions. However, these terms seem to be randomly chosen by investigators who design clinical trials and do not always reflect the true purpose of the study. A pragmatic-explanatory continuum indicator summary tool was thus developed with the aim of identifying the characteristics of clinical trials that distinguish between effectiveness and efficacy issues. We verified whether clinical trials used the criteria proposed by the indicator summary tool, and we categorized these clinical trials according to a new classification.METHOD:A systematic survey of randomized clinical trials was performed. We added a score ranging from 0 (more efficacious) to 10 (more effective) to each domain of the indicator summary tool and proposed the following classifications: high efficacy (Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2015-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/10392710.6061/clinics/2015(09)04Clinics; Vol. 70 No. 9 (2015); 618-622Clinics; v. 70 n. 9 (2015); 618-622Clinics; Vol. 70 Núm. 9 (2015); 618-6221980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/103927/102459Copyright (c) 2015 Clinicsinfo:eu-repo/semantics/openAccessDib, Regina ElJorge, Eliane ChavesKamegasawa, AméliaDaher, Solange RamiresSpagnuolo, Regina StellaSilva, Marise Pereira daBraga, Gabriel PereiraVolpato, EnilzeMódolo, Norma Sueli PinheiroBetini, MarluciValle, Adriana doCorrêa, IoneBazan, RodrigoAlmeida, Ricardo Augusto MBWeber, Silke Anna TheresaMolina, SilvanaYoo, HugoBoas, Paulo VillasCorrente, José EduardoMathew, JosephKapoor, AnilCarvalho, Raíssa PierriVital, Roberto BezerraBraz, Leandro GobboNascimento Junior, Paulo2015-09-15T20:12:20Zoai:revistas.usp.br:article/103927Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2015-09-15T20:12:20Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Differences between the real and the desired worlds in the results of clinical trials
title Differences between the real and the desired worlds in the results of clinical trials
spellingShingle Differences between the real and the desired worlds in the results of clinical trials
Dib, Regina El
title_short Differences between the real and the desired worlds in the results of clinical trials
title_full Differences between the real and the desired worlds in the results of clinical trials
title_fullStr Differences between the real and the desired worlds in the results of clinical trials
title_full_unstemmed Differences between the real and the desired worlds in the results of clinical trials
title_sort Differences between the real and the desired worlds in the results of clinical trials
author Dib, Regina El
author_facet Dib, Regina El
Jorge, Eliane Chaves
Kamegasawa, Amélia
Daher, Solange Ramires
Spagnuolo, Regina Stella
Silva, Marise Pereira da
Braga, Gabriel Pereira
Volpato, Enilze
Módolo, Norma Sueli Pinheiro
Betini, Marluci
Valle, Adriana do
Corrêa, Ione
Bazan, Rodrigo
Almeida, Ricardo Augusto MB
Weber, Silke Anna Theresa
Molina, Silvana
Yoo, Hugo
Boas, Paulo Villas
Corrente, José Eduardo
Mathew, Joseph
Kapoor, Anil
Carvalho, Raíssa Pierri
Vital, Roberto Bezerra
Braz, Leandro Gobbo
Nascimento Junior, Paulo
author_role author
author2 Jorge, Eliane Chaves
Kamegasawa, Amélia
Daher, Solange Ramires
Spagnuolo, Regina Stella
Silva, Marise Pereira da
Braga, Gabriel Pereira
Volpato, Enilze
Módolo, Norma Sueli Pinheiro
Betini, Marluci
Valle, Adriana do
Corrêa, Ione
Bazan, Rodrigo
Almeida, Ricardo Augusto MB
Weber, Silke Anna Theresa
Molina, Silvana
Yoo, Hugo
Boas, Paulo Villas
Corrente, José Eduardo
Mathew, Joseph
Kapoor, Anil
Carvalho, Raíssa Pierri
Vital, Roberto Bezerra
Braz, Leandro Gobbo
Nascimento Junior, Paulo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dib, Regina El
Jorge, Eliane Chaves
Kamegasawa, Amélia
Daher, Solange Ramires
Spagnuolo, Regina Stella
Silva, Marise Pereira da
Braga, Gabriel Pereira
Volpato, Enilze
Módolo, Norma Sueli Pinheiro
Betini, Marluci
Valle, Adriana do
Corrêa, Ione
Bazan, Rodrigo
Almeida, Ricardo Augusto MB
Weber, Silke Anna Theresa
Molina, Silvana
Yoo, Hugo
Boas, Paulo Villas
Corrente, José Eduardo
Mathew, Joseph
Kapoor, Anil
Carvalho, Raíssa Pierri
Vital, Roberto Bezerra
Braz, Leandro Gobbo
Nascimento Junior, Paulo
description OBJECTIVE:We refer to the effectiveness (known as pragmatic or real world) and efficacy (known as explanatory or desired or ideal world) of interventions. However, these terms seem to be randomly chosen by investigators who design clinical trials and do not always reflect the true purpose of the study. A pragmatic-explanatory continuum indicator summary tool was thus developed with the aim of identifying the characteristics of clinical trials that distinguish between effectiveness and efficacy issues. We verified whether clinical trials used the criteria proposed by the indicator summary tool, and we categorized these clinical trials according to a new classification.METHOD:A systematic survey of randomized clinical trials was performed. We added a score ranging from 0 (more efficacious) to 10 (more effective) to each domain of the indicator summary tool and proposed the following classifications: high efficacy (
publishDate 2015
dc.date.none.fl_str_mv 2015-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/103927
10.6061/clinics/2015(09)04
url https://www.revistas.usp.br/clinics/article/view/103927
identifier_str_mv 10.6061/clinics/2015(09)04
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/103927/102459
dc.rights.driver.fl_str_mv Copyright (c) 2015 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2015 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 70 No. 9 (2015); 618-622
Clinics; v. 70 n. 9 (2015); 618-622
Clinics; Vol. 70 Núm. 9 (2015); 618-622
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instname_str Universidade de São Paulo (USP)
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reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
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