Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/154798 |
Resumo: | Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Human papillomaviruses mediate cell transformation by the expression of two pleiotropic oncoproteins that alter major cellular regulatory pathways. However, these viruses are not complete carcinogens, and further alterations within the infected cells and in their microenvironment are necessary for tumor establishment and progression. Alterations in components of the extracellular matrix for instance, matrix metalloproteinases and some of their regulators such as tissue inhibitors of metalloproteinases, have been consistently reported in human papillomaviruses-associated diseases. Matrix metalloproteinases function by remodeling the extracellular matrix and alterations in their expression levels and/or activity are associated with pathological processes and clinical variables including local tumor invasion, metastasis, tumor relapse and overall patient prognosis and survival. In this review we present a summarized discussion on the current data concerning the impact of human papillomavirus infection on the activity and expression of extracellular matrix components. We further comment on the possibility of targeting extracellular matrix molecules in experimental treatment protocols. |
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Clinics |
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Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseasesHuman papillomavirusExtracellular matrixMatrix MetalloproteinasesTIMPsRECKInfection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Human papillomaviruses mediate cell transformation by the expression of two pleiotropic oncoproteins that alter major cellular regulatory pathways. However, these viruses are not complete carcinogens, and further alterations within the infected cells and in their microenvironment are necessary for tumor establishment and progression. Alterations in components of the extracellular matrix for instance, matrix metalloproteinases and some of their regulators such as tissue inhibitors of metalloproteinases, have been consistently reported in human papillomaviruses-associated diseases. Matrix metalloproteinases function by remodeling the extracellular matrix and alterations in their expression levels and/or activity are associated with pathological processes and clinical variables including local tumor invasion, metastasis, tumor relapse and overall patient prognosis and survival. In this review we present a summarized discussion on the current data concerning the impact of human papillomavirus infection on the activity and expression of extracellular matrix components. We further comment on the possibility of targeting extracellular matrix molecules in experimental treatment protocols.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-02-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/15479810.6061/clinics/2018/e551sClinics; Vol. 73 No. Suppl. 1 (2018); e551sClinics; v. 73 n. Suppl. 1 (2018); e551sClinics; Vol. 73 Núm. Suppl. 1 (2018); e551s1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/154798/150792Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessHerbster, SuellenPaladino, AndressaFreitas, Sumara deBoccardo, Enrique2019-05-14T11:48:25Zoai:revistas.usp.br:article/154798Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:25Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases |
title |
Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases |
spellingShingle |
Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases Herbster, Suellen Human papillomavirus Extracellular matrix Matrix Metalloproteinases TIMPs RECK |
title_short |
Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases |
title_full |
Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases |
title_fullStr |
Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases |
title_full_unstemmed |
Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases |
title_sort |
Alterations in the expression and activity of extracellular matrix components in HPV-associated infections and diseases |
author |
Herbster, Suellen |
author_facet |
Herbster, Suellen Paladino, Andressa Freitas, Sumara de Boccardo, Enrique |
author_role |
author |
author2 |
Paladino, Andressa Freitas, Sumara de Boccardo, Enrique |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Herbster, Suellen Paladino, Andressa Freitas, Sumara de Boccardo, Enrique |
dc.subject.por.fl_str_mv |
Human papillomavirus Extracellular matrix Matrix Metalloproteinases TIMPs RECK |
topic |
Human papillomavirus Extracellular matrix Matrix Metalloproteinases TIMPs RECK |
description |
Infection with human papillomaviruses is associated with a series of benign and malignant hyperproliferative diseases that impose a heavy burden on human populations. A subgroup of mucosal human papillomavirus types are associated with the majority of cervical cancers and a relevant fraction of vulvar, vaginal, anal, penile and head and neck carcinomas. Human papillomaviruses mediate cell transformation by the expression of two pleiotropic oncoproteins that alter major cellular regulatory pathways. However, these viruses are not complete carcinogens, and further alterations within the infected cells and in their microenvironment are necessary for tumor establishment and progression. Alterations in components of the extracellular matrix for instance, matrix metalloproteinases and some of their regulators such as tissue inhibitors of metalloproteinases, have been consistently reported in human papillomaviruses-associated diseases. Matrix metalloproteinases function by remodeling the extracellular matrix and alterations in their expression levels and/or activity are associated with pathological processes and clinical variables including local tumor invasion, metastasis, tumor relapse and overall patient prognosis and survival. In this review we present a summarized discussion on the current data concerning the impact of human papillomavirus infection on the activity and expression of extracellular matrix components. We further comment on the possibility of targeting extracellular matrix molecules in experimental treatment protocols. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/154798 10.6061/clinics/2018/e551s |
url |
https://www.revistas.usp.br/clinics/article/view/154798 |
identifier_str_mv |
10.6061/clinics/2018/e551s |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/154798/150792 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 73 No. Suppl. 1 (2018); e551s Clinics; v. 73 n. Suppl. 1 (2018); e551s Clinics; Vol. 73 Núm. Suppl. 1 (2018); e551s 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222763771756544 |