Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature

Detalhes bibliográficos
Autor(a) principal: Barros-Oliveira, Maria da Conceição
Data de Publicação: 2021
Outros Autores: Costa-Silva, Danylo Rafhael, Santos, Alesse Ribeiro dos, Pereira, Renato Oliveira, Soares-Júnior, José Maria, Silva, Benedito Borges da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/213025
Resumo: Breast cancer is the most frequently diagnosed malignant neoplasm in women and is considered a multifactorial disease of unknown etiology. One of the major risk factors is genetic alteration. Changes in CYP19A1 gene expression levels have been associated with increased risk and increased aggressiveness of breast cancer. Increased CYP19A1 gene expression and/or aromatase activity are among the major regulatory events for intratumoral production of estrogens in breast malignant tissues. This systematic review aimed to investigate the influence of CYP19A1 gene expression levels in women with breast cancer. The research was carried out using the PubMed, Scopus, and Web of Science databases. Searches were conducted between February 2 and May 15, 2019. Inclusion criteria were studies published between 2009 and 2019, English language publications, and human studies addressing the gene expression of CYP19A1 in breast cancer. A total of 6.068 studies were identified through PubMed (n=773), Scopus (n=2,927), and the Web of Science (n=2,368). After selecting and applying the inclusion and exclusion criteria, six articles were included in this systematic review. This systematic review provides evidence that increased or decreased levels of CYP19A1 gene expression may be related to pathological clinical factors of disease, MFS, OS, DFS, WATi, markers of metabolic function, concentrations of E1, FSH, and in the use of multiple exons 1 of the CYP19A1 gene in breast cancer.
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spelling Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literatureBreast CancerAromataseCYP19A1EstrogensGene ExpressionBreast cancer is the most frequently diagnosed malignant neoplasm in women and is considered a multifactorial disease of unknown etiology. One of the major risk factors is genetic alteration. Changes in CYP19A1 gene expression levels have been associated with increased risk and increased aggressiveness of breast cancer. Increased CYP19A1 gene expression and/or aromatase activity are among the major regulatory events for intratumoral production of estrogens in breast malignant tissues. This systematic review aimed to investigate the influence of CYP19A1 gene expression levels in women with breast cancer. The research was carried out using the PubMed, Scopus, and Web of Science databases. Searches were conducted between February 2 and May 15, 2019. Inclusion criteria were studies published between 2009 and 2019, English language publications, and human studies addressing the gene expression of CYP19A1 in breast cancer. A total of 6.068 studies were identified through PubMed (n=773), Scopus (n=2,927), and the Web of Science (n=2,368). After selecting and applying the inclusion and exclusion criteria, six articles were included in this systematic review. This systematic review provides evidence that increased or decreased levels of CYP19A1 gene expression may be related to pathological clinical factors of disease, MFS, OS, DFS, WATi, markers of metabolic function, concentrations of E1, FSH, and in the use of multiple exons 1 of the CYP19A1 gene in breast cancer.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2021-06-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21302510.6061/clinics/2021/e2846Clinics; Vol. 76 (2021); e2846Clinics; v. 76 (2021); e2846Clinics; Vol. 76 (2021); e28461980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213025/195039Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessBarros-Oliveira, Maria da ConceiçãoCosta-Silva, Danylo RafhaelSantos, Alesse Ribeiro dosPereira, Renato OliveiraSoares-Júnior, José MariaSilva, Benedito Borges da2023-07-06T13:04:10Zoai:revistas.usp.br:article/213025Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:10Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
title Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
spellingShingle Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
Barros-Oliveira, Maria da Conceição
Breast Cancer
Aromatase
CYP19A1
Estrogens
Gene Expression
title_short Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
title_full Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
title_fullStr Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
title_full_unstemmed Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
title_sort Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
author Barros-Oliveira, Maria da Conceição
author_facet Barros-Oliveira, Maria da Conceição
Costa-Silva, Danylo Rafhael
Santos, Alesse Ribeiro dos
Pereira, Renato Oliveira
Soares-Júnior, José Maria
Silva, Benedito Borges da
author_role author
author2 Costa-Silva, Danylo Rafhael
Santos, Alesse Ribeiro dos
Pereira, Renato Oliveira
Soares-Júnior, José Maria
Silva, Benedito Borges da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Barros-Oliveira, Maria da Conceição
Costa-Silva, Danylo Rafhael
Santos, Alesse Ribeiro dos
Pereira, Renato Oliveira
Soares-Júnior, José Maria
Silva, Benedito Borges da
dc.subject.por.fl_str_mv Breast Cancer
Aromatase
CYP19A1
Estrogens
Gene Expression
topic Breast Cancer
Aromatase
CYP19A1
Estrogens
Gene Expression
description Breast cancer is the most frequently diagnosed malignant neoplasm in women and is considered a multifactorial disease of unknown etiology. One of the major risk factors is genetic alteration. Changes in CYP19A1 gene expression levels have been associated with increased risk and increased aggressiveness of breast cancer. Increased CYP19A1 gene expression and/or aromatase activity are among the major regulatory events for intratumoral production of estrogens in breast malignant tissues. This systematic review aimed to investigate the influence of CYP19A1 gene expression levels in women with breast cancer. The research was carried out using the PubMed, Scopus, and Web of Science databases. Searches were conducted between February 2 and May 15, 2019. Inclusion criteria were studies published between 2009 and 2019, English language publications, and human studies addressing the gene expression of CYP19A1 in breast cancer. A total of 6.068 studies were identified through PubMed (n=773), Scopus (n=2,927), and the Web of Science (n=2,368). After selecting and applying the inclusion and exclusion criteria, six articles were included in this systematic review. This systematic review provides evidence that increased or decreased levels of CYP19A1 gene expression may be related to pathological clinical factors of disease, MFS, OS, DFS, WATi, markers of metabolic function, concentrations of E1, FSH, and in the use of multiple exons 1 of the CYP19A1 gene in breast cancer.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-14
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/213025
10.6061/clinics/2021/e2846
url https://www.revistas.usp.br/clinics/article/view/213025
identifier_str_mv 10.6061/clinics/2021/e2846
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/213025/195039
dc.rights.driver.fl_str_mv Copyright (c) 2023 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 76 (2021); e2846
Clinics; v. 76 (2021); e2846
Clinics; Vol. 76 (2021); e2846
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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