Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/213025 |
Resumo: | Breast cancer is the most frequently diagnosed malignant neoplasm in women and is considered a multifactorial disease of unknown etiology. One of the major risk factors is genetic alteration. Changes in CYP19A1 gene expression levels have been associated with increased risk and increased aggressiveness of breast cancer. Increased CYP19A1 gene expression and/or aromatase activity are among the major regulatory events for intratumoral production of estrogens in breast malignant tissues. This systematic review aimed to investigate the influence of CYP19A1 gene expression levels in women with breast cancer. The research was carried out using the PubMed, Scopus, and Web of Science databases. Searches were conducted between February 2 and May 15, 2019. Inclusion criteria were studies published between 2009 and 2019, English language publications, and human studies addressing the gene expression of CYP19A1 in breast cancer. A total of 6.068 studies were identified through PubMed (n=773), Scopus (n=2,927), and the Web of Science (n=2,368). After selecting and applying the inclusion and exclusion criteria, six articles were included in this systematic review. This systematic review provides evidence that increased or decreased levels of CYP19A1 gene expression may be related to pathological clinical factors of disease, MFS, OS, DFS, WATi, markers of metabolic function, concentrations of E1, FSH, and in the use of multiple exons 1 of the CYP19A1 gene in breast cancer. |
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Clinics |
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Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literatureBreast CancerAromataseCYP19A1EstrogensGene ExpressionBreast cancer is the most frequently diagnosed malignant neoplasm in women and is considered a multifactorial disease of unknown etiology. One of the major risk factors is genetic alteration. Changes in CYP19A1 gene expression levels have been associated with increased risk and increased aggressiveness of breast cancer. Increased CYP19A1 gene expression and/or aromatase activity are among the major regulatory events for intratumoral production of estrogens in breast malignant tissues. This systematic review aimed to investigate the influence of CYP19A1 gene expression levels in women with breast cancer. The research was carried out using the PubMed, Scopus, and Web of Science databases. Searches were conducted between February 2 and May 15, 2019. Inclusion criteria were studies published between 2009 and 2019, English language publications, and human studies addressing the gene expression of CYP19A1 in breast cancer. A total of 6.068 studies were identified through PubMed (n=773), Scopus (n=2,927), and the Web of Science (n=2,368). After selecting and applying the inclusion and exclusion criteria, six articles were included in this systematic review. This systematic review provides evidence that increased or decreased levels of CYP19A1 gene expression may be related to pathological clinical factors of disease, MFS, OS, DFS, WATi, markers of metabolic function, concentrations of E1, FSH, and in the use of multiple exons 1 of the CYP19A1 gene in breast cancer.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2021-06-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21302510.6061/clinics/2021/e2846Clinics; Vol. 76 (2021); e2846Clinics; v. 76 (2021); e2846Clinics; Vol. 76 (2021); e28461980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213025/195039Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessBarros-Oliveira, Maria da ConceiçãoCosta-Silva, Danylo RafhaelSantos, Alesse Ribeiro dosPereira, Renato OliveiraSoares-Júnior, José MariaSilva, Benedito Borges da2023-07-06T13:04:10Zoai:revistas.usp.br:article/213025Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:10Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature |
title |
Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature |
spellingShingle |
Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature Barros-Oliveira, Maria da Conceição Breast Cancer Aromatase CYP19A1 Estrogens Gene Expression |
title_short |
Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature |
title_full |
Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature |
title_fullStr |
Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature |
title_full_unstemmed |
Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature |
title_sort |
Influence of CYP19A1 gene expression levels in women with breast cancer: a systematic review of the literature |
author |
Barros-Oliveira, Maria da Conceição |
author_facet |
Barros-Oliveira, Maria da Conceição Costa-Silva, Danylo Rafhael Santos, Alesse Ribeiro dos Pereira, Renato Oliveira Soares-Júnior, José Maria Silva, Benedito Borges da |
author_role |
author |
author2 |
Costa-Silva, Danylo Rafhael Santos, Alesse Ribeiro dos Pereira, Renato Oliveira Soares-Júnior, José Maria Silva, Benedito Borges da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Barros-Oliveira, Maria da Conceição Costa-Silva, Danylo Rafhael Santos, Alesse Ribeiro dos Pereira, Renato Oliveira Soares-Júnior, José Maria Silva, Benedito Borges da |
dc.subject.por.fl_str_mv |
Breast Cancer Aromatase CYP19A1 Estrogens Gene Expression |
topic |
Breast Cancer Aromatase CYP19A1 Estrogens Gene Expression |
description |
Breast cancer is the most frequently diagnosed malignant neoplasm in women and is considered a multifactorial disease of unknown etiology. One of the major risk factors is genetic alteration. Changes in CYP19A1 gene expression levels have been associated with increased risk and increased aggressiveness of breast cancer. Increased CYP19A1 gene expression and/or aromatase activity are among the major regulatory events for intratumoral production of estrogens in breast malignant tissues. This systematic review aimed to investigate the influence of CYP19A1 gene expression levels in women with breast cancer. The research was carried out using the PubMed, Scopus, and Web of Science databases. Searches were conducted between February 2 and May 15, 2019. Inclusion criteria were studies published between 2009 and 2019, English language publications, and human studies addressing the gene expression of CYP19A1 in breast cancer. A total of 6.068 studies were identified through PubMed (n=773), Scopus (n=2,927), and the Web of Science (n=2,368). After selecting and applying the inclusion and exclusion criteria, six articles were included in this systematic review. This systematic review provides evidence that increased or decreased levels of CYP19A1 gene expression may be related to pathological clinical factors of disease, MFS, OS, DFS, WATi, markers of metabolic function, concentrations of E1, FSH, and in the use of multiple exons 1 of the CYP19A1 gene in breast cancer. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213025 10.6061/clinics/2021/e2846 |
url |
https://www.revistas.usp.br/clinics/article/view/213025 |
identifier_str_mv |
10.6061/clinics/2021/e2846 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213025/195039 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 76 (2021); e2846 Clinics; v. 76 (2021); e2846 Clinics; Vol. 76 (2021); e2846 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222766239055872 |