Autophagy and intermittent fasting: the connection for cancer therapy?
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/154899 |
Resumo: | Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Macroautophagy (herein referred to as autophagy) is a conserved lysosomal degradation pathway for the intracellular recycling of macromolecules and clearance of damaged organelles and misfolded proteins to ensure cellular homeostasis. Dysfunctional autophagy contributes to many diseases, including cancer. Autophagy can suppress or promote tumors depending on the developmental stage and tumor type, and modulating autophagy for cancer treatment is an interesting therapeutic approach currently under intense investigation. Nutritional restriction is a promising protocol to modulate autophagy and enhance the efficacy of anticancer therapies while protecting normal cells. Here, the description and role of autophagy in tumorigenesis will be summarized. Moreover, the possibility of using fasting as an adjuvant therapy for cancer treatment, as well as the molecular mechanisms underlying this approach, will be presented. |
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Clinics |
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Autophagy and intermittent fasting: the connection for cancer therapy?ApoptosisAutophagyFastingCancerTherapyCancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Macroautophagy (herein referred to as autophagy) is a conserved lysosomal degradation pathway for the intracellular recycling of macromolecules and clearance of damaged organelles and misfolded proteins to ensure cellular homeostasis. Dysfunctional autophagy contributes to many diseases, including cancer. Autophagy can suppress or promote tumors depending on the developmental stage and tumor type, and modulating autophagy for cancer treatment is an interesting therapeutic approach currently under intense investigation. Nutritional restriction is a promising protocol to modulate autophagy and enhance the efficacy of anticancer therapies while protecting normal cells. Here, the description and role of autophagy in tumorigenesis will be summarized. Moreover, the possibility of using fasting as an adjuvant therapy for cancer treatment, as well as the molecular mechanisms underlying this approach, will be presented.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-02-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/15489910.6061/clinics/2018/e814sClinics; Vol. 73 No. Suppl. 1 (2018); clinics/2018/e814sClinics; v. 73 n. Suppl. 1 (2018); clinics/2018/e814sClinics; Vol. 73 Núm. Suppl. 1 (2018); clinics/2018/e814s1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/154899/150812Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessAntunes, FernandaErustes, Adolfo GarciaCosta, Angelíca JardimNascimento, Ana CarolinaBincoletto, ClaudiaUreshino, Rodrigo PortesPereira, Gustavo José SilvaSmaili, Soraya Soubhi2019-05-14T11:48:25Zoai:revistas.usp.br:article/154899Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-05-14T11:48:25Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Autophagy and intermittent fasting: the connection for cancer therapy? |
title |
Autophagy and intermittent fasting: the connection for cancer therapy? |
spellingShingle |
Autophagy and intermittent fasting: the connection for cancer therapy? Antunes, Fernanda Apoptosis Autophagy Fasting Cancer Therapy |
title_short |
Autophagy and intermittent fasting: the connection for cancer therapy? |
title_full |
Autophagy and intermittent fasting: the connection for cancer therapy? |
title_fullStr |
Autophagy and intermittent fasting: the connection for cancer therapy? |
title_full_unstemmed |
Autophagy and intermittent fasting: the connection for cancer therapy? |
title_sort |
Autophagy and intermittent fasting: the connection for cancer therapy? |
author |
Antunes, Fernanda |
author_facet |
Antunes, Fernanda Erustes, Adolfo Garcia Costa, Angelíca Jardim Nascimento, Ana Carolina Bincoletto, Claudia Ureshino, Rodrigo Portes Pereira, Gustavo José Silva Smaili, Soraya Soubhi |
author_role |
author |
author2 |
Erustes, Adolfo Garcia Costa, Angelíca Jardim Nascimento, Ana Carolina Bincoletto, Claudia Ureshino, Rodrigo Portes Pereira, Gustavo José Silva Smaili, Soraya Soubhi |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Antunes, Fernanda Erustes, Adolfo Garcia Costa, Angelíca Jardim Nascimento, Ana Carolina Bincoletto, Claudia Ureshino, Rodrigo Portes Pereira, Gustavo José Silva Smaili, Soraya Soubhi |
dc.subject.por.fl_str_mv |
Apoptosis Autophagy Fasting Cancer Therapy |
topic |
Apoptosis Autophagy Fasting Cancer Therapy |
description |
Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Macroautophagy (herein referred to as autophagy) is a conserved lysosomal degradation pathway for the intracellular recycling of macromolecules and clearance of damaged organelles and misfolded proteins to ensure cellular homeostasis. Dysfunctional autophagy contributes to many diseases, including cancer. Autophagy can suppress or promote tumors depending on the developmental stage and tumor type, and modulating autophagy for cancer treatment is an interesting therapeutic approach currently under intense investigation. Nutritional restriction is a promising protocol to modulate autophagy and enhance the efficacy of anticancer therapies while protecting normal cells. Here, the description and role of autophagy in tumorigenesis will be summarized. Moreover, the possibility of using fasting as an adjuvant therapy for cancer treatment, as well as the molecular mechanisms underlying this approach, will be presented. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-18 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/154899 10.6061/clinics/2018/e814s |
url |
https://www.revistas.usp.br/clinics/article/view/154899 |
identifier_str_mv |
10.6061/clinics/2018/e814s |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/154899/150812 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 73 No. Suppl. 1 (2018); clinics/2018/e814s Clinics; v. 73 n. Suppl. 1 (2018); clinics/2018/e814s Clinics; Vol. 73 Núm. Suppl. 1 (2018); clinics/2018/e814s 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764088426496 |