Leprosy reactions: coinfections as a possible risk factor
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/47926 |
Resumo: | OBJECTIVE: This study aimed to determine the frequency of coinfections in leprosy patients and whether there is a relationship between the presence of coinfections and the development of leprosy reactional episodes. METHOD: A cross-sectional study based on an analysis of the medical records of the patients who were treated at the Leprosy Clinics of the Ribeirão Preto Medical School, University of São Paulo, was conducted from 2000 to 2010. Information was recorded regarding the age, sex, clinical status, WHO classification, treatment, presence of reactions and coinfections. Focal and systemic infections were diagnosed based on the history, physical examination, and laboratory tests. Multinomial logistic regression was used to evaluate the associations between the leprosy reactions and the patients' gender, age, WHO classification and coinfections. RESULTS: Two hundred twenty-five patients were studied. Most of these patients were males (155/225 = 68.8%) of an average age of 49.31±15.92 years, and the most prevalent clinical manifestation was the multibacillary (MB) form (n = 146), followed by the paucibacillary (PB) form (n = 79). Erythema nodosum leprosum (ENL) was more prevalent (78/122 = 63.9%) than the reversal reaction (RR) (44/122 = 36.1%), especially in the MB patients (OR 5.07; CI 2.86-8.99; p |
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Leprosy reactions: coinfections as a possible risk factorLeprosy ReactionMycobacterium lepraeOral InfectionCoinfectionOBJECTIVE: This study aimed to determine the frequency of coinfections in leprosy patients and whether there is a relationship between the presence of coinfections and the development of leprosy reactional episodes. METHOD: A cross-sectional study based on an analysis of the medical records of the patients who were treated at the Leprosy Clinics of the Ribeirão Preto Medical School, University of São Paulo, was conducted from 2000 to 2010. Information was recorded regarding the age, sex, clinical status, WHO classification, treatment, presence of reactions and coinfections. Focal and systemic infections were diagnosed based on the history, physical examination, and laboratory tests. Multinomial logistic regression was used to evaluate the associations between the leprosy reactions and the patients' gender, age, WHO classification and coinfections. RESULTS: Two hundred twenty-five patients were studied. Most of these patients were males (155/225 = 68.8%) of an average age of 49.31±15.92 years, and the most prevalent clinical manifestation was the multibacillary (MB) form (n = 146), followed by the paucibacillary (PB) form (n = 79). Erythema nodosum leprosum (ENL) was more prevalent (78/122 = 63.9%) than the reversal reaction (RR) (44/122 = 36.1%), especially in the MB patients (OR 5.07; CI 2.86-8.99; pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4792610.6061/clinics/2012(10)05Clinics; Vol. 67 No. 10 (2012); 1145-1148Clinics; v. 67 n. 10 (2012); 1145-1148Clinics; Vol. 67 Núm. 10 (2012); 1145-11481980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/47926/51666Motta, Ana Carolina F.Pereira, Karla JulianaTarquínio, Daniela ChavesVieira, Mariana BelliniMiyake, KarinaFoss, Norma Tiraboschiinfo:eu-repo/semantics/openAccess2012-12-13T11:00:25Zoai:revistas.usp.br:article/47926Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-12-13T11:00:25Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Leprosy reactions: coinfections as a possible risk factor |
title |
Leprosy reactions: coinfections as a possible risk factor |
spellingShingle |
Leprosy reactions: coinfections as a possible risk factor Motta, Ana Carolina F. Leprosy Reaction Mycobacterium leprae Oral Infection Coinfection |
title_short |
Leprosy reactions: coinfections as a possible risk factor |
title_full |
Leprosy reactions: coinfections as a possible risk factor |
title_fullStr |
Leprosy reactions: coinfections as a possible risk factor |
title_full_unstemmed |
Leprosy reactions: coinfections as a possible risk factor |
title_sort |
Leprosy reactions: coinfections as a possible risk factor |
author |
Motta, Ana Carolina F. |
author_facet |
Motta, Ana Carolina F. Pereira, Karla Juliana Tarquínio, Daniela Chaves Vieira, Mariana Bellini Miyake, Karina Foss, Norma Tiraboschi |
author_role |
author |
author2 |
Pereira, Karla Juliana Tarquínio, Daniela Chaves Vieira, Mariana Bellini Miyake, Karina Foss, Norma Tiraboschi |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Motta, Ana Carolina F. Pereira, Karla Juliana Tarquínio, Daniela Chaves Vieira, Mariana Bellini Miyake, Karina Foss, Norma Tiraboschi |
dc.subject.por.fl_str_mv |
Leprosy Reaction Mycobacterium leprae Oral Infection Coinfection |
topic |
Leprosy Reaction Mycobacterium leprae Oral Infection Coinfection |
description |
OBJECTIVE: This study aimed to determine the frequency of coinfections in leprosy patients and whether there is a relationship between the presence of coinfections and the development of leprosy reactional episodes. METHOD: A cross-sectional study based on an analysis of the medical records of the patients who were treated at the Leprosy Clinics of the Ribeirão Preto Medical School, University of São Paulo, was conducted from 2000 to 2010. Information was recorded regarding the age, sex, clinical status, WHO classification, treatment, presence of reactions and coinfections. Focal and systemic infections were diagnosed based on the history, physical examination, and laboratory tests. Multinomial logistic regression was used to evaluate the associations between the leprosy reactions and the patients' gender, age, WHO classification and coinfections. RESULTS: Two hundred twenty-five patients were studied. Most of these patients were males (155/225 = 68.8%) of an average age of 49.31±15.92 years, and the most prevalent clinical manifestation was the multibacillary (MB) form (n = 146), followed by the paucibacillary (PB) form (n = 79). Erythema nodosum leprosum (ENL) was more prevalent (78/122 = 63.9%) than the reversal reaction (RR) (44/122 = 36.1%), especially in the MB patients (OR 5.07; CI 2.86-8.99; p |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/47926 10.6061/clinics/2012(10)05 |
url |
https://www.revistas.usp.br/clinics/article/view/47926 |
identifier_str_mv |
10.6061/clinics/2012(10)05 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/47926/51666 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 67 No. 10 (2012); 1145-1148 Clinics; v. 67 n. 10 (2012); 1145-1148 Clinics; Vol. 67 Núm. 10 (2012); 1145-1148 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222759160119296 |