Leprosy reactions: coinfections as a possible risk factor

Detalhes bibliográficos
Autor(a) principal: Motta, Ana Carolina F.
Data de Publicação: 2012
Outros Autores: Pereira, Karla Juliana, Tarquínio, Daniela Chaves, Vieira, Mariana Bellini, Miyake, Karina, Foss, Norma Tiraboschi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/47926
Resumo: OBJECTIVE: This study aimed to determine the frequency of coinfections in leprosy patients and whether there is a relationship between the presence of coinfections and the development of leprosy reactional episodes. METHOD: A cross-sectional study based on an analysis of the medical records of the patients who were treated at the Leprosy Clinics of the Ribeirão Preto Medical School, University of São Paulo, was conducted from 2000 to 2010. Information was recorded regarding the age, sex, clinical status, WHO classification, treatment, presence of reactions and coinfections. Focal and systemic infections were diagnosed based on the history, physical examination, and laboratory tests. Multinomial logistic regression was used to evaluate the associations between the leprosy reactions and the patients' gender, age, WHO classification and coinfections. RESULTS: Two hundred twenty-five patients were studied. Most of these patients were males (155/225 = 68.8%) of an average age of 49.31±15.92 years, and the most prevalent clinical manifestation was the multibacillary (MB) form (n = 146), followed by the paucibacillary (PB) form (n = 79). Erythema nodosum leprosum (ENL) was more prevalent (78/122 = 63.9%) than the reversal reaction (RR) (44/122 = 36.1%), especially in the MB patients (OR 5.07; CI 2.86-8.99; p
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spelling Leprosy reactions: coinfections as a possible risk factorLeprosy ReactionMycobacterium lepraeOral InfectionCoinfectionOBJECTIVE: This study aimed to determine the frequency of coinfections in leprosy patients and whether there is a relationship between the presence of coinfections and the development of leprosy reactional episodes. METHOD: A cross-sectional study based on an analysis of the medical records of the patients who were treated at the Leprosy Clinics of the Ribeirão Preto Medical School, University of São Paulo, was conducted from 2000 to 2010. Information was recorded regarding the age, sex, clinical status, WHO classification, treatment, presence of reactions and coinfections. Focal and systemic infections were diagnosed based on the history, physical examination, and laboratory tests. Multinomial logistic regression was used to evaluate the associations between the leprosy reactions and the patients' gender, age, WHO classification and coinfections. RESULTS: Two hundred twenty-five patients were studied. Most of these patients were males (155/225 = 68.8%) of an average age of 49.31±15.92 years, and the most prevalent clinical manifestation was the multibacillary (MB) form (n = 146), followed by the paucibacillary (PB) form (n = 79). Erythema nodosum leprosum (ENL) was more prevalent (78/122 = 63.9%) than the reversal reaction (RR) (44/122 = 36.1%), especially in the MB patients (OR 5.07; CI 2.86-8.99; pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4792610.6061/clinics/2012(10)05Clinics; Vol. 67 No. 10 (2012); 1145-1148Clinics; v. 67 n. 10 (2012); 1145-1148Clinics; Vol. 67 Núm. 10 (2012); 1145-11481980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/47926/51666Motta, Ana Carolina F.Pereira, Karla JulianaTarquínio, Daniela ChavesVieira, Mariana BelliniMiyake, KarinaFoss, Norma Tiraboschiinfo:eu-repo/semantics/openAccess2012-12-13T11:00:25Zoai:revistas.usp.br:article/47926Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-12-13T11:00:25Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Leprosy reactions: coinfections as a possible risk factor
title Leprosy reactions: coinfections as a possible risk factor
spellingShingle Leprosy reactions: coinfections as a possible risk factor
Motta, Ana Carolina F.
Leprosy Reaction
Mycobacterium leprae
Oral Infection
Coinfection
title_short Leprosy reactions: coinfections as a possible risk factor
title_full Leprosy reactions: coinfections as a possible risk factor
title_fullStr Leprosy reactions: coinfections as a possible risk factor
title_full_unstemmed Leprosy reactions: coinfections as a possible risk factor
title_sort Leprosy reactions: coinfections as a possible risk factor
author Motta, Ana Carolina F.
author_facet Motta, Ana Carolina F.
Pereira, Karla Juliana
Tarquínio, Daniela Chaves
Vieira, Mariana Bellini
Miyake, Karina
Foss, Norma Tiraboschi
author_role author
author2 Pereira, Karla Juliana
Tarquínio, Daniela Chaves
Vieira, Mariana Bellini
Miyake, Karina
Foss, Norma Tiraboschi
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Motta, Ana Carolina F.
Pereira, Karla Juliana
Tarquínio, Daniela Chaves
Vieira, Mariana Bellini
Miyake, Karina
Foss, Norma Tiraboschi
dc.subject.por.fl_str_mv Leprosy Reaction
Mycobacterium leprae
Oral Infection
Coinfection
topic Leprosy Reaction
Mycobacterium leprae
Oral Infection
Coinfection
description OBJECTIVE: This study aimed to determine the frequency of coinfections in leprosy patients and whether there is a relationship between the presence of coinfections and the development of leprosy reactional episodes. METHOD: A cross-sectional study based on an analysis of the medical records of the patients who were treated at the Leprosy Clinics of the Ribeirão Preto Medical School, University of São Paulo, was conducted from 2000 to 2010. Information was recorded regarding the age, sex, clinical status, WHO classification, treatment, presence of reactions and coinfections. Focal and systemic infections were diagnosed based on the history, physical examination, and laboratory tests. Multinomial logistic regression was used to evaluate the associations between the leprosy reactions and the patients' gender, age, WHO classification and coinfections. RESULTS: Two hundred twenty-five patients were studied. Most of these patients were males (155/225 = 68.8%) of an average age of 49.31±15.92 years, and the most prevalent clinical manifestation was the multibacillary (MB) form (n = 146), followed by the paucibacillary (PB) form (n = 79). Erythema nodosum leprosum (ENL) was more prevalent (78/122 = 63.9%) than the reversal reaction (RR) (44/122 = 36.1%), especially in the MB patients (OR 5.07; CI 2.86-8.99; p
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/47926
10.6061/clinics/2012(10)05
url https://www.revistas.usp.br/clinics/article/view/47926
identifier_str_mv 10.6061/clinics/2012(10)05
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/47926/51666
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 67 No. 10 (2012); 1145-1148
Clinics; v. 67 n. 10 (2012); 1145-1148
Clinics; Vol. 67 Núm. 10 (2012); 1145-1148
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
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instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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