A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/214032 |
Resumo: | Objective: To characterize the peripheral and central auditory pathways in individuals with Acute Lymphoid Leukemia (ALL) and compare assessment results before and during chemotherapy. Method: The study included 17 subjects with ALL, divided into two age groups: 3 to 6 (11 individuals) and 7 to 16 years old (6 individuals). Each subject was evaluated twice (before and 3 to 6 months after chemotherapy treatment) with the following procedures: medical history survey, otoscopy, Pure-Tone Threshold (PTA) and speech audiometry, acoustic immittance measures, Brainstem Auditory Evoked Potentials (BAEP) and Long-Latency Auditory Evoked Potentials (LLAEP). Results: PTA was normal. Tympanometry was abnormal in the second assessment in 2 individuals aged 3 to 6 years. One subject in each age group had absent ipsilateral acoustic reflexes. In high-frequency audiometry, 1 individual had abnormal results. BAEP was abnormal in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years and 2 (first assessment) and 1 individual (second assessment) aged 7 to 16 years. As for LLAEP, P1 latency was increased in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years. Conclusion: No hearing loss was identified in the behavioral audiological assessment. BAEP was more affected in the 3-to-6-year-old group, with greater impairment in the lower brainstem in the first and second assessments. In LLAEP, P1 was the most impaired component in children aged 3 to 6 years, and P2 and N2 were so for those 7 to 16 years old, especially in the second assessment. |
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Clinics |
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A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemiaAuditory evoked potentialsAuditory perceptionHearingLeukemia-lymphoblastic precursor cell lymphomaPharmacological treatmentObjective: To characterize the peripheral and central auditory pathways in individuals with Acute Lymphoid Leukemia (ALL) and compare assessment results before and during chemotherapy. Method: The study included 17 subjects with ALL, divided into two age groups: 3 to 6 (11 individuals) and 7 to 16 years old (6 individuals). Each subject was evaluated twice (before and 3 to 6 months after chemotherapy treatment) with the following procedures: medical history survey, otoscopy, Pure-Tone Threshold (PTA) and speech audiometry, acoustic immittance measures, Brainstem Auditory Evoked Potentials (BAEP) and Long-Latency Auditory Evoked Potentials (LLAEP). Results: PTA was normal. Tympanometry was abnormal in the second assessment in 2 individuals aged 3 to 6 years. One subject in each age group had absent ipsilateral acoustic reflexes. In high-frequency audiometry, 1 individual had abnormal results. BAEP was abnormal in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years and 2 (first assessment) and 1 individual (second assessment) aged 7 to 16 years. As for LLAEP, P1 latency was increased in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years. Conclusion: No hearing loss was identified in the behavioral audiological assessment. BAEP was more affected in the 3-to-6-year-old group, with greater impairment in the lower brainstem in the first and second assessments. In LLAEP, P1 was the most impaired component in children aged 3 to 6 years, and P2 and N2 were so for those 7 to 16 years old, especially in the second assessment.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2023-06-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21403210.1016/j.clinsp.2023.100234Clinics; Vol. 78 (2023); 100234Clinics; v. 78 (2023); 100234Clinics; Vol. 78 (2023); 1002341980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/214032/196269Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessVosgrau, Jéssica SalesSilva, Liliane Aparecida FagundesOdone Filho, VicenteMatas, Carla Gentile2023-07-06T13:05:40Zoai:revistas.usp.br:article/214032Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:05:40Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia |
title |
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia |
spellingShingle |
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia Vosgrau, Jéssica Sales Auditory evoked potentials Auditory perception Hearing Leukemia-lymphoblastic precursor cell lymphoma Pharmacological treatment |
title_short |
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia |
title_full |
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia |
title_fullStr |
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia |
title_full_unstemmed |
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia |
title_sort |
A longitudinal study of the peripheral and central auditory pathways in individuals with acute lymphoid leukemia |
author |
Vosgrau, Jéssica Sales |
author_facet |
Vosgrau, Jéssica Sales Silva, Liliane Aparecida Fagundes Odone Filho, Vicente Matas, Carla Gentile |
author_role |
author |
author2 |
Silva, Liliane Aparecida Fagundes Odone Filho, Vicente Matas, Carla Gentile |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Vosgrau, Jéssica Sales Silva, Liliane Aparecida Fagundes Odone Filho, Vicente Matas, Carla Gentile |
dc.subject.por.fl_str_mv |
Auditory evoked potentials Auditory perception Hearing Leukemia-lymphoblastic precursor cell lymphoma Pharmacological treatment |
topic |
Auditory evoked potentials Auditory perception Hearing Leukemia-lymphoblastic precursor cell lymphoma Pharmacological treatment |
description |
Objective: To characterize the peripheral and central auditory pathways in individuals with Acute Lymphoid Leukemia (ALL) and compare assessment results before and during chemotherapy. Method: The study included 17 subjects with ALL, divided into two age groups: 3 to 6 (11 individuals) and 7 to 16 years old (6 individuals). Each subject was evaluated twice (before and 3 to 6 months after chemotherapy treatment) with the following procedures: medical history survey, otoscopy, Pure-Tone Threshold (PTA) and speech audiometry, acoustic immittance measures, Brainstem Auditory Evoked Potentials (BAEP) and Long-Latency Auditory Evoked Potentials (LLAEP). Results: PTA was normal. Tympanometry was abnormal in the second assessment in 2 individuals aged 3 to 6 years. One subject in each age group had absent ipsilateral acoustic reflexes. In high-frequency audiometry, 1 individual had abnormal results. BAEP was abnormal in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years and 2 (first assessment) and 1 individual (second assessment) aged 7 to 16 years. As for LLAEP, P1 latency was increased in 5 (first assessment) and 7 individuals (second assessment) aged 3 to 6 years. Conclusion: No hearing loss was identified in the behavioral audiological assessment. BAEP was more affected in the 3-to-6-year-old group, with greater impairment in the lower brainstem in the first and second assessments. In LLAEP, P1 was the most impaired component in children aged 3 to 6 years, and P2 and N2 were so for those 7 to 16 years old, especially in the second assessment. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/214032 10.1016/j.clinsp.2023.100234 |
url |
https://www.revistas.usp.br/clinics/article/view/214032 |
identifier_str_mv |
10.1016/j.clinsp.2023.100234 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/214032/196269 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 78 (2023); 100234 Clinics; v. 78 (2023); 100234 Clinics; Vol. 78 (2023); 100234 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222767410315264 |