Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea

Detalhes bibliográficos
Autor(a) principal: Neves, Christiane
Data de Publicação: 2010
Outros Autores: Tufik, Sérgio, Chediek, Felipe, Poyares, Dalva, Cintra, Fátima, Roizenblatt, Marina, Abrantes, Fabiano, Monteiro, Marina Ariza, Roizenblatt, Suely
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/18441
Resumo: OBJECTIVE: To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS: Thirteen male patients with severe obstructive sleep apnea (mean age 43±10 years with a mean body mass index of 26.7±1.9 kg/m²) received a single 50-mg dose of sildenafil or a placebo at bedtime. All-night polysomnography and heart rate variability were recorded. Frequency domain analysis of heart rate variability was performed for the central five-minute sample of the longest uninterrupted interval of slow wave and rapid eye movement sleep, as well as for one-minute samples during apnea and during slow wave and rapid eye movement sleep after resumption of respiration. RESULTS: Compared to the placebo, sildenafil was associated with an increase in the normalized high-frequency (HFnu) components and a decrease in the low/high-frequency components of the heart rate variability ratio (LF/HF) in slow wave sleep (p
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spelling Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea Nitric oxideHeart rate variabilityPhosphodiesterase-5Erectile dysfunctionOxyhemoglobin OBJECTIVE: To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS: Thirteen male patients with severe obstructive sleep apnea (mean age 43±10 years with a mean body mass index of 26.7±1.9 kg/m²) received a single 50-mg dose of sildenafil or a placebo at bedtime. All-night polysomnography and heart rate variability were recorded. Frequency domain analysis of heart rate variability was performed for the central five-minute sample of the longest uninterrupted interval of slow wave and rapid eye movement sleep, as well as for one-minute samples during apnea and during slow wave and rapid eye movement sleep after resumption of respiration. RESULTS: Compared to the placebo, sildenafil was associated with an increase in the normalized high-frequency (HFnu) components and a decrease in the low/high-frequency components of the heart rate variability ratio (LF/HF) in slow wave sleep (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1844110.1590/S1807-59322010000400008Clinics; Vol. 65 No. 4 (2010); 393-400 Clinics; v. 65 n. 4 (2010); 393-400 Clinics; Vol. 65 Núm. 4 (2010); 393-400 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18441/20504Neves, ChristianeTufik, SérgioChediek, FelipePoyares, DalvaCintra, FátimaRoizenblatt, MarinaAbrantes, FabianoMonteiro, Marina ArizaRoizenblatt, Suelyinfo:eu-repo/semantics/openAccess2012-05-23T11:23:52Zoai:revistas.usp.br:article/18441Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:23:52Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
title Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
spellingShingle Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
Neves, Christiane
Nitric oxide
Heart rate variability
Phosphodiesterase-5
Erectile dysfunction
Oxyhemoglobin
title_short Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
title_full Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
title_fullStr Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
title_full_unstemmed Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
title_sort Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
author Neves, Christiane
author_facet Neves, Christiane
Tufik, Sérgio
Chediek, Felipe
Poyares, Dalva
Cintra, Fátima
Roizenblatt, Marina
Abrantes, Fabiano
Monteiro, Marina Ariza
Roizenblatt, Suely
author_role author
author2 Tufik, Sérgio
Chediek, Felipe
Poyares, Dalva
Cintra, Fátima
Roizenblatt, Marina
Abrantes, Fabiano
Monteiro, Marina Ariza
Roizenblatt, Suely
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Neves, Christiane
Tufik, Sérgio
Chediek, Felipe
Poyares, Dalva
Cintra, Fátima
Roizenblatt, Marina
Abrantes, Fabiano
Monteiro, Marina Ariza
Roizenblatt, Suely
dc.subject.por.fl_str_mv Nitric oxide
Heart rate variability
Phosphodiesterase-5
Erectile dysfunction
Oxyhemoglobin
topic Nitric oxide
Heart rate variability
Phosphodiesterase-5
Erectile dysfunction
Oxyhemoglobin
description OBJECTIVE: To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS: Thirteen male patients with severe obstructive sleep apnea (mean age 43±10 years with a mean body mass index of 26.7±1.9 kg/m²) received a single 50-mg dose of sildenafil or a placebo at bedtime. All-night polysomnography and heart rate variability were recorded. Frequency domain analysis of heart rate variability was performed for the central five-minute sample of the longest uninterrupted interval of slow wave and rapid eye movement sleep, as well as for one-minute samples during apnea and during slow wave and rapid eye movement sleep after resumption of respiration. RESULTS: Compared to the placebo, sildenafil was associated with an increase in the normalized high-frequency (HFnu) components and a decrease in the low/high-frequency components of the heart rate variability ratio (LF/HF) in slow wave sleep (p
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18441
10.1590/S1807-59322010000400008
url https://www.revistas.usp.br/clinics/article/view/18441
identifier_str_mv 10.1590/S1807-59322010000400008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18441/20504
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 65 No. 4 (2010); 393-400
Clinics; v. 65 n. 4 (2010); 393-400
Clinics; Vol. 65 Núm. 4 (2010); 393-400
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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