Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/18441 |
Resumo: | OBJECTIVE: To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS: Thirteen male patients with severe obstructive sleep apnea (mean age 43±10 years with a mean body mass index of 26.7±1.9 kg/m²) received a single 50-mg dose of sildenafil or a placebo at bedtime. All-night polysomnography and heart rate variability were recorded. Frequency domain analysis of heart rate variability was performed for the central five-minute sample of the longest uninterrupted interval of slow wave and rapid eye movement sleep, as well as for one-minute samples during apnea and during slow wave and rapid eye movement sleep after resumption of respiration. RESULTS: Compared to the placebo, sildenafil was associated with an increase in the normalized high-frequency (HFnu) components and a decrease in the low/high-frequency components of the heart rate variability ratio (LF/HF) in slow wave sleep (p |
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Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea Nitric oxideHeart rate variabilityPhosphodiesterase-5Erectile dysfunctionOxyhemoglobin OBJECTIVE: To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS: Thirteen male patients with severe obstructive sleep apnea (mean age 43±10 years with a mean body mass index of 26.7±1.9 kg/m²) received a single 50-mg dose of sildenafil or a placebo at bedtime. All-night polysomnography and heart rate variability were recorded. Frequency domain analysis of heart rate variability was performed for the central five-minute sample of the longest uninterrupted interval of slow wave and rapid eye movement sleep, as well as for one-minute samples during apnea and during slow wave and rapid eye movement sleep after resumption of respiration. RESULTS: Compared to the placebo, sildenafil was associated with an increase in the normalized high-frequency (HFnu) components and a decrease in the low/high-frequency components of the heart rate variability ratio (LF/HF) in slow wave sleep (pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1844110.1590/S1807-59322010000400008Clinics; Vol. 65 No. 4 (2010); 393-400 Clinics; v. 65 n. 4 (2010); 393-400 Clinics; Vol. 65 Núm. 4 (2010); 393-400 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18441/20504Neves, ChristianeTufik, SérgioChediek, FelipePoyares, DalvaCintra, FátimaRoizenblatt, MarinaAbrantes, FabianoMonteiro, Marina ArizaRoizenblatt, Suelyinfo:eu-repo/semantics/openAccess2012-05-23T11:23:52Zoai:revistas.usp.br:article/18441Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:23:52Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea |
title |
Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea |
spellingShingle |
Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea Neves, Christiane Nitric oxide Heart rate variability Phosphodiesterase-5 Erectile dysfunction Oxyhemoglobin |
title_short |
Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea |
title_full |
Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea |
title_fullStr |
Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea |
title_full_unstemmed |
Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea |
title_sort |
Effects of sildenafil on autonomic nervous function during sleep in obstructive sleep apnea |
author |
Neves, Christiane |
author_facet |
Neves, Christiane Tufik, Sérgio Chediek, Felipe Poyares, Dalva Cintra, Fátima Roizenblatt, Marina Abrantes, Fabiano Monteiro, Marina Ariza Roizenblatt, Suely |
author_role |
author |
author2 |
Tufik, Sérgio Chediek, Felipe Poyares, Dalva Cintra, Fátima Roizenblatt, Marina Abrantes, Fabiano Monteiro, Marina Ariza Roizenblatt, Suely |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Neves, Christiane Tufik, Sérgio Chediek, Felipe Poyares, Dalva Cintra, Fátima Roizenblatt, Marina Abrantes, Fabiano Monteiro, Marina Ariza Roizenblatt, Suely |
dc.subject.por.fl_str_mv |
Nitric oxide Heart rate variability Phosphodiesterase-5 Erectile dysfunction Oxyhemoglobin |
topic |
Nitric oxide Heart rate variability Phosphodiesterase-5 Erectile dysfunction Oxyhemoglobin |
description |
OBJECTIVE: To evaluate the effects of sildenafil on the autonomic nervous system in patients with severe obstructive sleep apnea. METHODS: Thirteen male patients with severe obstructive sleep apnea (mean age 43±10 years with a mean body mass index of 26.7±1.9 kg/m²) received a single 50-mg dose of sildenafil or a placebo at bedtime. All-night polysomnography and heart rate variability were recorded. Frequency domain analysis of heart rate variability was performed for the central five-minute sample of the longest uninterrupted interval of slow wave and rapid eye movement sleep, as well as for one-minute samples during apnea and during slow wave and rapid eye movement sleep after resumption of respiration. RESULTS: Compared to the placebo, sildenafil was associated with an increase in the normalized high-frequency (HFnu) components and a decrease in the low/high-frequency components of the heart rate variability ratio (LF/HF) in slow wave sleep (p |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18441 10.1590/S1807-59322010000400008 |
url |
https://www.revistas.usp.br/clinics/article/view/18441 |
identifier_str_mv |
10.1590/S1807-59322010000400008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18441/20504 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 65 No. 4 (2010); 393-400 Clinics; v. 65 n. 4 (2010); 393-400 Clinics; Vol. 65 Núm. 4 (2010); 393-400 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222755329671168 |