Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/213559 |
Resumo: | Background: This study aimed to evaluate the associations between Lipoprotein (a) ‒ Lp(a) levels and carotid Intima-Media Thickness (cIMT) and with carotid plaques in healthy subjects because of previous contradictory data. Methods: A total of 317 healthy normolipidemic subjects (20‒77 years old) were selected. The cIMT and atherosclerotic plaques were determined by B-mode ultrasonography. Mann-Whitney tests were performed to compare the groups according to Lp(a) levels and to explore the associations between Lp(a), carotid plaques, and cIMT, logistic and linear regression analyses were performed. Results: Studied population (51% females, median age 43 years old) presented carotid plaques and cIMT ≥ 0.9 mm in 23% and 18% of the participants, respectively. The group with Lp(a) levels > 30 mg/dL presented significantly higher age and atherosclerotic plaques. Indeed, multivariate linear regression analysis showed a significant association between Lp(a), age, and race. On the other hand, logistic regression analysis demonstrated that the subjects with Lp(a) > 30 mg/dL have a significantly high risk of carotid plaques. Conclusion: The data from the present study indicate that Lp(a) levels above 30 mg/dL contribute to the development of carotid plaques even in apparently healthy participants. |
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Clinics |
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Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individualsLipoprotein (a)Carotid atherosclerosisCarotid plaquesBackground: This study aimed to evaluate the associations between Lipoprotein (a) ‒ Lp(a) levels and carotid Intima-Media Thickness (cIMT) and with carotid plaques in healthy subjects because of previous contradictory data. Methods: A total of 317 healthy normolipidemic subjects (20‒77 years old) were selected. The cIMT and atherosclerotic plaques were determined by B-mode ultrasonography. Mann-Whitney tests were performed to compare the groups according to Lp(a) levels and to explore the associations between Lp(a), carotid plaques, and cIMT, logistic and linear regression analyses were performed. Results: Studied population (51% females, median age 43 years old) presented carotid plaques and cIMT ≥ 0.9 mm in 23% and 18% of the participants, respectively. The group with Lp(a) levels > 30 mg/dL presented significantly higher age and atherosclerotic plaques. Indeed, multivariate linear regression analysis showed a significant association between Lp(a), age, and race. On the other hand, logistic regression analysis demonstrated that the subjects with Lp(a) > 30 mg/dL have a significantly high risk of carotid plaques. Conclusion: The data from the present study indicate that Lp(a) levels above 30 mg/dL contribute to the development of carotid plaques even in apparently healthy participants.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2022-09-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21355910.1016/j.clinsp.2022.100107Clinics; Vol. 77 (2022); 100107Clinics; v. 77 (2022); 100107Clinics; Vol. 77 (2022); 1001071980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213559/195642Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessFrança, VictorGomes, Érica Ivana LázaroCampos, Edite Vieira Silva deZago, Vanessa Helena de SouzaNunes, Valéria SuttiFaria, Eliana Cotta de2023-07-06T13:04:59Zoai:revistas.usp.br:article/213559Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:59Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals |
title |
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals |
spellingShingle |
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals França, Victor Lipoprotein (a) Carotid atherosclerosis Carotid plaques |
title_short |
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals |
title_full |
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals |
title_fullStr |
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals |
title_full_unstemmed |
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals |
title_sort |
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals |
author |
França, Victor |
author_facet |
França, Victor Gomes, Érica Ivana Lázaro Campos, Edite Vieira Silva de Zago, Vanessa Helena de Souza Nunes, Valéria Sutti Faria, Eliana Cotta de |
author_role |
author |
author2 |
Gomes, Érica Ivana Lázaro Campos, Edite Vieira Silva de Zago, Vanessa Helena de Souza Nunes, Valéria Sutti Faria, Eliana Cotta de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
França, Victor Gomes, Érica Ivana Lázaro Campos, Edite Vieira Silva de Zago, Vanessa Helena de Souza Nunes, Valéria Sutti Faria, Eliana Cotta de |
dc.subject.por.fl_str_mv |
Lipoprotein (a) Carotid atherosclerosis Carotid plaques |
topic |
Lipoprotein (a) Carotid atherosclerosis Carotid plaques |
description |
Background: This study aimed to evaluate the associations between Lipoprotein (a) ‒ Lp(a) levels and carotid Intima-Media Thickness (cIMT) and with carotid plaques in healthy subjects because of previous contradictory data. Methods: A total of 317 healthy normolipidemic subjects (20‒77 years old) were selected. The cIMT and atherosclerotic plaques were determined by B-mode ultrasonography. Mann-Whitney tests were performed to compare the groups according to Lp(a) levels and to explore the associations between Lp(a), carotid plaques, and cIMT, logistic and linear regression analyses were performed. Results: Studied population (51% females, median age 43 years old) presented carotid plaques and cIMT ≥ 0.9 mm in 23% and 18% of the participants, respectively. The group with Lp(a) levels > 30 mg/dL presented significantly higher age and atherosclerotic plaques. Indeed, multivariate linear regression analysis showed a significant association between Lp(a), age, and race. On the other hand, logistic regression analysis demonstrated that the subjects with Lp(a) > 30 mg/dL have a significantly high risk of carotid plaques. Conclusion: The data from the present study indicate that Lp(a) levels above 30 mg/dL contribute to the development of carotid plaques even in apparently healthy participants. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213559 10.1016/j.clinsp.2022.100107 |
url |
https://www.revistas.usp.br/clinics/article/view/213559 |
identifier_str_mv |
10.1016/j.clinsp.2022.100107 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/213559/195642 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 77 (2022); 100107 Clinics; v. 77 (2022); 100107 Clinics; Vol. 77 (2022); 100107 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222766984593408 |