Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/214035 |
Resumo: | Background This study aimed to evaluate the association between Monocyte Lymphocyte Ratio (MLR) and Abdominal Aortic Calcification (AAC) in adults over 40 years of age in the United States. Methods Data were collected from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). AAC was quantified by the Kauppila score system based on dual-energy X-Ray absorptiometry. Severe AAC was defined as a total AAC score > 6. The lymphocyte count and monocyte count can be directly obtained from laboratory data files. Multivariable logistic regression models were used to determine the association between MLR and the AAC score and severe AAC. Results A total of 3,045 participants were included in the present study. After adjusting for multiple covariates, MLR was positively associated with higher AAC score (β = 0.21, 95% CI 0.07, 0.34, p = 0.0032) and the odds of severe AAC increased by 14% per 0.1 unit increase in the MLR (OR = 1.14, 95% CI 1.00, 1.31, p = 0.0541). The Odds Ratio (OR) (95% CI) of severe AAC for participants in MLR tertile 3 was 1.88 (1.02, 3.47) compared with those in tertile 1 (p for trend = 0.0341). Subgroup analyses showed that a stronger association was detected in the elderly compared with non-elderly (p for interaction = 0.0346) and diabetes compared with non-diabetes (borderline significant p for interaction = 0.0578). Conclusion In adults in the United States, MLR was associated with higher AAC scores and a higher probability of severe AAC. MLR may become a promising tool to predict the risk of AAC. |
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Clinics |
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Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional studyMonocyte lymphocyte ratioAbdominal aortic calcificationVascular calcificationCross-sectional study Background This study aimed to evaluate the association between Monocyte Lymphocyte Ratio (MLR) and Abdominal Aortic Calcification (AAC) in adults over 40 years of age in the United States. Methods Data were collected from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). AAC was quantified by the Kauppila score system based on dual-energy X-Ray absorptiometry. Severe AAC was defined as a total AAC score > 6. The lymphocyte count and monocyte count can be directly obtained from laboratory data files. Multivariable logistic regression models were used to determine the association between MLR and the AAC score and severe AAC. Results A total of 3,045 participants were included in the present study. After adjusting for multiple covariates, MLR was positively associated with higher AAC score (β = 0.21, 95% CI 0.07, 0.34, p = 0.0032) and the odds of severe AAC increased by 14% per 0.1 unit increase in the MLR (OR = 1.14, 95% CI 1.00, 1.31, p = 0.0541). The Odds Ratio (OR) (95% CI) of severe AAC for participants in MLR tertile 3 was 1.88 (1.02, 3.47) compared with those in tertile 1 (p for trend = 0.0341). Subgroup analyses showed that a stronger association was detected in the elderly compared with non-elderly (p for interaction = 0.0346) and diabetes compared with non-diabetes (borderline significant p for interaction = 0.0578). Conclusion In adults in the United States, MLR was associated with higher AAC scores and a higher probability of severe AAC. MLR may become a promising tool to predict the risk of AAC. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2023-06-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21403510.1016/j.clinsp.2023.100232Clinics; Vol. 78 (2023); 100232Clinics; v. 78 (2023); 100232Clinics; Vol. 78 (2023); 1002321980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/214035/196270Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessZuo, PeiyuanXu, RanranHu, LiyaHu, WeiTong, Song2023-07-06T13:05:40Zoai:revistas.usp.br:article/214035Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:05:40Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study |
title |
Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study |
spellingShingle |
Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study Zuo, Peiyuan Monocyte lymphocyte ratio Abdominal aortic calcification Vascular calcification Cross-sectional study |
title_short |
Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study |
title_full |
Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study |
title_fullStr |
Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study |
title_full_unstemmed |
Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study |
title_sort |
Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study |
author |
Zuo, Peiyuan |
author_facet |
Zuo, Peiyuan Xu, Ranran Hu, Liya Hu, Wei Tong, Song |
author_role |
author |
author2 |
Xu, Ranran Hu, Liya Hu, Wei Tong, Song |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Zuo, Peiyuan Xu, Ranran Hu, Liya Hu, Wei Tong, Song |
dc.subject.por.fl_str_mv |
Monocyte lymphocyte ratio Abdominal aortic calcification Vascular calcification Cross-sectional study |
topic |
Monocyte lymphocyte ratio Abdominal aortic calcification Vascular calcification Cross-sectional study |
description |
Background This study aimed to evaluate the association between Monocyte Lymphocyte Ratio (MLR) and Abdominal Aortic Calcification (AAC) in adults over 40 years of age in the United States. Methods Data were collected from the 2013–2014 National Health and Nutrition Examination Survey (NHANES). AAC was quantified by the Kauppila score system based on dual-energy X-Ray absorptiometry. Severe AAC was defined as a total AAC score > 6. The lymphocyte count and monocyte count can be directly obtained from laboratory data files. Multivariable logistic regression models were used to determine the association between MLR and the AAC score and severe AAC. Results A total of 3,045 participants were included in the present study. After adjusting for multiple covariates, MLR was positively associated with higher AAC score (β = 0.21, 95% CI 0.07, 0.34, p = 0.0032) and the odds of severe AAC increased by 14% per 0.1 unit increase in the MLR (OR = 1.14, 95% CI 1.00, 1.31, p = 0.0541). The Odds Ratio (OR) (95% CI) of severe AAC for participants in MLR tertile 3 was 1.88 (1.02, 3.47) compared with those in tertile 1 (p for trend = 0.0341). Subgroup analyses showed that a stronger association was detected in the elderly compared with non-elderly (p for interaction = 0.0346) and diabetes compared with non-diabetes (borderline significant p for interaction = 0.0578). Conclusion In adults in the United States, MLR was associated with higher AAC scores and a higher probability of severe AAC. MLR may become a promising tool to predict the risk of AAC. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/214035 10.1016/j.clinsp.2023.100232 |
url |
https://www.revistas.usp.br/clinics/article/view/214035 |
identifier_str_mv |
10.1016/j.clinsp.2023.100232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/214035/196270 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 78 (2023); 100232 Clinics; v. 78 (2023); 100232 Clinics; Vol. 78 (2023); 100232 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222767412412416 |