Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/18405 |
Resumo: | OBJECTIVES: The aim of this study was to investigate the activities of serum paraoxonase and arylesterase in patients with ankylosing spondylitis with respect to those of healthy controls, to assess whether these enzyme levels are related to disease activity and functional capacity. METHODS: The study included 32 patients with ankylosing spondylitis whose diagnoses were made according to the modified New York criteria as well as 25 healthy controls matched for age and sex. The Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index were applied to the ankylosing spondylitis patients. As laboratory parameters, the erythrocyte sedimentation rate and serum C-reactive protein level were measured in patients and control subjects. Paraoxonase and arylesterase enzyme activities were measured using appropriate methods. RESULTS: No statistically significant differences (p>;0.05) were found between the ankylosing spondylitis patients and controls in terms of serum paraoxonase or arylesterase levels. Furthermore, there was no correlation between clinical and laboratory parameters in patients with ankylosing spondylitis. CONCLUSION: Serum paraoxonase and arylesterase levels in ankylosing spondylitis patients may not differ from those of healthy controls, and there is no significant correlation between antioxidant parameters and the Bath Ankylosing Spondylitis Disease Activity Index or Bath Ankylosing Spondylitis Functional Index scores in ankylosing spondylitis patients. Further research is needed to provide deeper understanding of this disease. |
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Clinics |
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Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients Ankylosing SpondylitisParaoxonaseArylesteraseAntioxidant enzymesOxidative stress OBJECTIVES: The aim of this study was to investigate the activities of serum paraoxonase and arylesterase in patients with ankylosing spondylitis with respect to those of healthy controls, to assess whether these enzyme levels are related to disease activity and functional capacity. METHODS: The study included 32 patients with ankylosing spondylitis whose diagnoses were made according to the modified New York criteria as well as 25 healthy controls matched for age and sex. The Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index were applied to the ankylosing spondylitis patients. As laboratory parameters, the erythrocyte sedimentation rate and serum C-reactive protein level were measured in patients and control subjects. Paraoxonase and arylesterase enzyme activities were measured using appropriate methods. RESULTS: No statistically significant differences (p>;0.05) were found between the ankylosing spondylitis patients and controls in terms of serum paraoxonase or arylesterase levels. Furthermore, there was no correlation between clinical and laboratory parameters in patients with ankylosing spondylitis. CONCLUSION: Serum paraoxonase and arylesterase levels in ankylosing spondylitis patients may not differ from those of healthy controls, and there is no significant correlation between antioxidant parameters and the Bath Ankylosing Spondylitis Disease Activity Index or Bath Ankylosing Spondylitis Functional Index scores in ankylosing spondylitis patients. Further research is needed to provide deeper understanding of this disease. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1840510.1590/S1807-59322010000200009Clinics; Vol. 65 No. 2 (2010); 175-179 Clinics; v. 65 n. 2 (2010); 175-179 Clinics; Vol. 65 Núm. 2 (2010); 175-179 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18405/20468Erdem, Fazile HatipogluKaratay, SalihaYildirim, KadirKiziltunc, Ahmetinfo:eu-repo/semantics/openAccess2012-05-23T11:20:38Zoai:revistas.usp.br:article/18405Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:20:38Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients |
title |
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients |
spellingShingle |
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients Erdem, Fazile Hatipoglu Ankylosing Spondylitis Paraoxonase Arylesterase Antioxidant enzymes Oxidative stress |
title_short |
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients |
title_full |
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients |
title_fullStr |
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients |
title_full_unstemmed |
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients |
title_sort |
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients |
author |
Erdem, Fazile Hatipoglu |
author_facet |
Erdem, Fazile Hatipoglu Karatay, Saliha Yildirim, Kadir Kiziltunc, Ahmet |
author_role |
author |
author2 |
Karatay, Saliha Yildirim, Kadir Kiziltunc, Ahmet |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Erdem, Fazile Hatipoglu Karatay, Saliha Yildirim, Kadir Kiziltunc, Ahmet |
dc.subject.por.fl_str_mv |
Ankylosing Spondylitis Paraoxonase Arylesterase Antioxidant enzymes Oxidative stress |
topic |
Ankylosing Spondylitis Paraoxonase Arylesterase Antioxidant enzymes Oxidative stress |
description |
OBJECTIVES: The aim of this study was to investigate the activities of serum paraoxonase and arylesterase in patients with ankylosing spondylitis with respect to those of healthy controls, to assess whether these enzyme levels are related to disease activity and functional capacity. METHODS: The study included 32 patients with ankylosing spondylitis whose diagnoses were made according to the modified New York criteria as well as 25 healthy controls matched for age and sex. The Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index were applied to the ankylosing spondylitis patients. As laboratory parameters, the erythrocyte sedimentation rate and serum C-reactive protein level were measured in patients and control subjects. Paraoxonase and arylesterase enzyme activities were measured using appropriate methods. RESULTS: No statistically significant differences (p>;0.05) were found between the ankylosing spondylitis patients and controls in terms of serum paraoxonase or arylesterase levels. Furthermore, there was no correlation between clinical and laboratory parameters in patients with ankylosing spondylitis. CONCLUSION: Serum paraoxonase and arylesterase levels in ankylosing spondylitis patients may not differ from those of healthy controls, and there is no significant correlation between antioxidant parameters and the Bath Ankylosing Spondylitis Disease Activity Index or Bath Ankylosing Spondylitis Functional Index scores in ankylosing spondylitis patients. Further research is needed to provide deeper understanding of this disease. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18405 10.1590/S1807-59322010000200009 |
url |
https://www.revistas.usp.br/clinics/article/view/18405 |
identifier_str_mv |
10.1590/S1807-59322010000200009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/18405/20468 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 65 No. 2 (2010); 175-179 Clinics; v. 65 n. 2 (2010); 175-179 Clinics; Vol. 65 Núm. 2 (2010); 175-179 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222755277242368 |